Recruiting and Retaining Older African American and Hispanic Boys in After-School Programs: What We Know and What We Still Need to Learn

This brief is the third in P/PV's GroundWork series, which aims to summarize available evidence on a variety of social policy topics to provide a firm foundation for future work. Created in partnership with the Collaborative for Building After-School Systems (CBASS), the brief provides an overview of promising strategies for recruiting and retaining middle- and high-school-aged African-American and Hispanic males in after-school programs.The brief's findings are based on a review of relevant literature and interviews with 10 after-school programs identified by CBASS intermediaries as successful in these areas. The strategies identified mirror the strategies deemed important for recruiting and retaining older youth more broadly -- regardless of race and gender -- and include accessibility, cultural relevance and flexibility. However the programs interviewed did tailor these strategies to meet the specific needs of older minority boys. While this brief provides a starting point for future research, further work is needed, particularly given the positive outcomes associated with sustained participation in high-quality after-school programs and the challenges many programs face in attracting and retaining this population

AfterZone: Outcomes for Youth Participating in Providence's Citywide After-School System

Presents findings from an evaluation of an afterschool program model that features a wide range of school- and community-based activities for middle school youth, a central coordinating body, and strong roots in the school context. Outlines implications

AfterZone: Outcomes for Youth Participating in Providence's Citywide After-School System, Executive Summary

This executive summary highlights the main findings from our participation and outcomes analysis of the AfterZone initiative a citywide system-building effort in Providence, RI, that aims to provide high-quality, accessible out-of-school-time services to middle school youth

Illuminating Solutions: The Youth Violence Reduction Partnership

Over the last decade, P/PV has undertaken several studies of the Philadelphia-based Youth Violence Reduction Partnership (YVRP), an intensive collaboration that targets young people deemed at highest risk of being involved in a homicide. YVRP provides young probationers with enhanced supervision and support, with the goal of keeping them out of trouble and putting them on a path toward productive adulthood

High School Students as Mentors: Findings From the Big Brothers Big Sisters School-Based Mentoring Impact Study Executive Summary

Recently, high schools have become a popular source of mentors for school-based mentoring (SBM) programs. This executive summary outlines key findings and recommendations from our High School Students as Mentors report, which drew on data from our large-scale random assignment impact study of Big Brothers Big Sisters SBM (Herrera, et al. 2007). Our research indicated that, on average, high school students were much less effective than adults at yielding impacts for the youth they mentor, but it also identified several program practices that were linked with longer, stronger and more effective high school mentor relationships

Health Equity: Everyone Counts - The Need for Disaggregated Data on Marginalized or Excluded Racial/Ethnic Groups

When data are unavailable for a marginalized racial/ethnic group, their needs are rendered invisible when policies are made, resources are allocated, and programs are designed and implemented.Regardless of intentions, the ways in which data are collected, analyzed, and reported may have inequitable consequences. The effects of policies that make data unavailable on excluded or marginalized groups can put those populations at further disadvantage that may reflect systemic racism.This report, produced in partnership with the University of California, San Francisco, should be relevant to those planning, conducting, or funding ethnic/racial data collection, analysis, and/ or reporting, for both federally and privately funded data, in all sectors, not only health

Making a Difference in Schools: The Big Brothers Big Sisters School-Based Mentoring Impact Study Executive Summary

Serving almost 870,000 youth nationwide, school-based mentoring is one of the fastest growing forms of mentoring in the US today. Making a Difference in Schools presents findings from a landmark random assignment impact study of Big Brothers Big Sisters School-Based Mentoring -- the first national study of this program model. This executive summary highlights nine key findings from the full report and outlines several recommendations for policy and practice

Making a Difference in Schools: The Big Brothers Big Sisters School-Based Mentoring Impact Study

School-based mentoring is one of the fastest growing forms of mentoring in the US today; yet, few studies have rigorously examined its impacts. This landmark random assignment impact study of Big Brothers Big Sisters School-Based Mentoring is the first national study of this program model. It involves 10 agencies, 71 schools and 1,139 9- to 16-year-old youth randomly assigned to either a treatment group of program participants or a control group of their non-mentored peers. Surveys were administered to all participating youth, their teachers and mentors in the fall of 2004, spring of 2005 and late fall of 2005.The report describes the programs and their participants and answers several key questions, including: Does school-based mentoring work? What kinds of mentoring experiences help to ensure benefits? How much do these programs cost? Our findings highlight both the strengths of this program model and its current limitations and suggest several recommendations for refining this promising model-recommendations that Big Brothers Big Sisters agencies across the country are already working to implement

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Policy and practice-relevant youth physical activity research center agenda

Background: The Physical Activity Research Center developed a research agenda that addresses youth physical activity (PA) and healthy weight, and aligns with the Robert Wood Johnson Foundation’s Culture of Health. This paper summarizes prioritized research studies with a focus on youth at higher risk for inactive lifestyles and childhood obesity in urban and rural communities. Methods: Systematic literature reviews, a survey, and discussions with practitioners and researchers provided guidance on research questions to build evidence and inform effective strategies to promote healthy weight and PA in youth across race, cultural, and economic groups. Results: The research team developed a matrix of potential research questions, identified priority questions, and designed targeted studies to address some of the priority questions and inform advocacy efforts. The studies selected examine strategies advocating for activity-friendly communities, Play Streets, park use, and PA of youth in the summer. A broader set of research priorities for youth PA is proposed. Conclusion: Establishing the Physical Activity Research Center research agenda identified important initial and future research studies to promote and ensure healthy weight and healthy levels of PA for at-risk youth. Results will be disseminated with the goal of promoting equitable access to PA for youth