Risk factors and predictors for recurrent venous thrombosis : building blocks for a prognostic model

Secondary prevention of recurrent venous can be achieved in two ways, either by elimination of modifiable risk factors or by extending the anticoagulant treatment period in patients at high risk of recurrence. The aim of this thesis was to identify modifiable risk factors for as well as factors that might be able to predict recurrent venous thrombotic events. This thesis reports on an increased risk of recurrences in women who continue or start using hormonal contraceptives after a first venous thrombotic event, suggesting that refraining from this modifiable risk factor decreases the risk of recurrence. Furthermore, this thesis describes several factors, male sex, unprovoked first event, levels of coagulation factor VIII and antibiotic use to be associated with recurrent venous thrombosis. These factors should eventually be taken together and used to build a prognostic model, which will be able to predict recurrences at a refined and individual level.LUMC / Geneeskund

Predicting the risk of recurrent venous thrombosis: What the future might bring

An important clinical problem in the management of venous thrombosis is to determine whether a patient can safely cease anticoagulant therapy. In this Forum article, we summarize the predictive performance of several prediction models for recurrent thrombosis, as well as for bleeding while using anticoagulants. Patients with provoked first thrombosis (considered "low risk") are now denied long-term treatment, although a strong gradient in risk can be found in this group. We furthermore discuss the problem of an unclear definition of "(un)provoked" and show that this affects the yield of currently available prediction scores plus the limitations of a "one-size-fits-all" strategy. Better prediction tools are urgently needed. We propose a strategy for future studies for which the following should be considered: (a) reporting of absolute risks next to C-statistics, (b) model applicable to all patients, (c) no discontinuation of anticoagulation for measurement of predictors.Thrombosis and Hemostasi

The risk of venous thrombosis in patients with malignancy is largely mediated through levels of factor VIII and von Willebrand factor

Clinical epidemiolog

The risk of recurrent venous thrombosis in patients with (LOWER) leg cast immobilisation

Optimising joint reconstruction management in arthritis and bone tumour patient

Epidemiology of cancer-associated venous thrombosis

Thrombosis and Hemostasi

Recurrent venous thrombosis in premenopausal women: effect of hormonal contraceptive use

Technology assessment of reproductive medicin

High risk of recurrent venous thrombosis in patients with lower-leg cast immobilization

Clinical epidemiolog

Malignancies and risk of recurrent venous thrombosis

Thrombosis and Hemostasi