Vergence eye movements in patients with schizophrenia

AbstractPrevious studies have shown that smooth pursuit eye movements are impaired in patients with schizophrenia. However, under normal viewing conditions, targets move not only in the frontoparallel plane but also in depth, and tracking them requires both smooth pursuit and vergence eye movements. Although previous studies in humans and non-human primates suggest that these two eye movement subsystems are relatively independent of one another, to our knowledge, there have been no prior studies of vergence tracking behavior in patients with schizophrenia. Therefore, we have investigated these eye movements in patients with schizophrenia and in healthy controls. We found that patients with schizophrenia exhibited substantially lower gains compared to healthy controls during vergence tracking at all tested speeds (e.g. 0.25Hz vergence tracking mean gain of 0.59 vs. 0.86). Further, consistent with previous reports, patients with schizophrenia exhibited significantly lower gains than healthy controls during smooth pursuit at higher target speeds (e.g. 0.5Hz smooth pursuit mean gain of 0.64 vs. 0.73). In addition, there was a modest (r≈0.5), but significant, correlation between smooth pursuit and vergence tracking performance in patients with schizophrenia. Our observations clearly demonstrate substantial vergence tracking deficits in patients with schizophrenia. In these patients, deficits for smooth pursuit and vergence tracking are partially correlated suggesting overlap in the central control of smooth pursuit and vergence eye movements

Short-Time Scale Dynamics in the Responses to Multiple Stimuli in Visual Cortex

Many previous studies have used the presentation of multiple stimuli in the receptive fields (RFs) of visual cortical neurons to explore how neurons might operate on multiple inputs. Most of these experiments have used two fixed stimulus locations within the RF of each neuron. Here the effects of using different positions within the RF of a neuron were explored. The stimuli were presented singly at one of six locations, and also at 15 pair-wise combinations, for 24 V2 cortical neurons in two macaque monkeys. There was considerable variability in how pairs of stimuli interacted within the receptive field of any given neuron: changing the position of the stimuli could result in enhancement, winner-take-all, or suppression relative to the strongest response to a stimulus presented by itself. Across the population of neurons there was no correlation between response strength and response latency. However, for many stimulus pairs the response latency was tightly locked to the shortest response latency of any single stimulus presented by itself independent of changes in response magnitude. In other words, a stimulus that by itself elicited a relatively long latency response, could affect the magnitude of the response to a pair of stimuli, but could not change the latency. A model is proposed whereby changes in response magnitude that do not result in changes in response latency reflect rapid feed-forward processing mechanisms, and these rapid mechanisms can suppress slower, longer time-constant processing mechanisms. These results may provide constraints on the development of models of cortical information processing