12 research outputs found
Near-infrared-actuated devices for remotely controlled drug delivery
A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained on-state drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications
Depth-dependent photodegradation of marine dissolved organic matter.
Marine dissolved organic matter (DOM) in surface and deep waters of the eastern Atlantic Ocean and Sargasso Sea was analyzed by excitation emission matrix (EEM) fluorescence spectroscopy and parallel factor analysis (PARAFAC). Photo-degradation with semi-continuous monitoring of EEMs and absorbance spectra was used to measure the photo-degradation kinetics and changes of the PARAFAC components in a depth profile of DOM at the Bermuda Atlantic Time Series (BATS) station in the Sargasso Sea. A five component model was fit to the EEMs, which included traditional terrestrial-like, marine-like, and protein-like components. Terrestrial-like components showed the expected high photo-reactivity, but surprisingly, the traditional marine-like peak showed slight photo-production in surface waters, which may account for its prevalence in marine systems. Surface waters were depleted in photo-labile components while protein-like fluorescent components were enriched, consistent with previous studies. Ultra-high resolution mass spectrometry detected unique aliphatic compounds in the surface waters at the BATS site, which may be photo-produced or photo-stable. Principle component and canonical analysis showed strong correlations between relative contributions of unsaturated/aromatic molecular formulas and depth, with aliphatic compounds more prevalent in surface waters and aromatic compounds in deep waters. Strong correlations were seen between these aromatic compounds and humic-like fluorescent components. The rapid photo-degradation of the deep-sea fluorescent DOM in addition to the surface water relative depletion of aromatic compounds suggests that deep-sea fluorescent DOM may be too photochemically labile to survive during overturning circulation
Comparison of 12-step groups to mutual help alternatives for AUD in a large, national study: Differences in membership characteristics and group participation, cohesion, and satisfaction
Translational regulation of protein synthesis during light-induced chloroplast development in Euglena
Why did it happen to me? Social cognition processes in adjustment and recovery from criminal victimisation and illness
Enzyme Immobilization on Nanomaterials for Biosensor and Biocatalyst in Food and Biomedical Industry
Properties of jets in Z boson events from 1.8 TeV p\u304p collisions
We present a study of events with Z bosons and hadronic jets produced in p\uafp collisions at a center-of-mass energy of 1.8 TeV. The data consist of 6708 Z\u2192e+e 12 decays from 106pb 121 of integrated luminosity collected using the CDF detector at the Fermilab Tevatron Collider. The Z+ 65n jet cross sections and jet production properties have been measured for n=1 to 4. The data are compared to predictions of leading-order QCD matrix element calculations with added gluon radiation and simulated parton fragmentation
Inclusive jet cross section in p\u304p collisions at 1as = 1.8 TeV
The inclusive jet differential cross section has been measured for jet transverse energies, ET, from 15 to 440 GeV, in the pseudorapidity region 0.1 64|\u3b7| 640.7. The results are based on 19.5pb 121 of data collected by the CDF Collaboration at the Fermilab Tevatron collider. The data are compared with QCD predictions for various sets of parton distribution functions. The cross section for jets with ET>200GeV is significantly higher than current predictions based on O(\u3b13s) perturbative QCD calculations. Various possible explanations for the high- ET excess are discussed
Measurement of the \u3b3 + D*\ub1 cross section in p\u304p collisions at 1as = 1.8 TeV
We have measured the cross section of gamma + D-*+/- production in <(p)over bar p> collisions at root s = 1.8 TeV using the Collider Detector at Fermilab. In this kinematic region, the Compton scattering process (g(c) --> gamma(c)) is expected to dominate and thus provide a direct link to the charm quark density in the proton. From the 45 +/- 18 gamma + D-*+/- candidates in a 16.4 pb(-1) data sample, we have determined the production cross section to be 0.38 +/- 0.15(stat) +/- 0.11(syst) nb for the rapidity range y(D-*+/-) < 1.2 and y(gamma) < 0.9, and for the transverse momentum range p(T)(D-*+/-) > 6 GeV/c and 16 < p(T)(gamma) < 40 GeV/c. The measured cross section is compared to a theoretical prediction