20 research outputs found
Short-Term Drop in Antibody Titer after the Third Dose of SARS-CoV-2 BNT162b2 Vaccine in Adults
Little is known about the longevity of antibodies after a third dose of the mRNA-based SARS-CoV-2 vaccine BNT162b2 (BioNTech/Pfizer, Mainz, Germany). Therefore, serum antibody levels were evaluated after a third dose of BNT162b2 in healthy adult healthcare workers in Germany. These antibody levels dropped significantly within a short period of 11 weeks from 4155.59 ± 2373.65 BAU/mL to 2389.10 ± 1433.90 BAU/mL, p-value < 0.001 but remained higher than after the second dose (611.92 ± 450.31 BAU/mL). To evaluate the quality of the humoral immune response, we additionally measured neutralizing antibodies, which also showed a small but significant decrease within this short period. These data underline the positive effect of a third dose of BNT162b2 concerning antibody re-induction but also shows a drop of Anti-SARS-CoV-2-IgG within a short span of time
The People's Plan for Overcoming the Hurricane Katrina Blues
The Peoples' Plan is a strategic action plan for the recovery of the 9th Ward. It was created based on conversations with residents-some struggling to return home, others intent on remaining in a neighborhood that has always been their own. The Peoples' Plan provides a thorough assessment of what must be done to provide recovery in one of the hardest hit areas of the City, and provides a recovery model for all badly flooded areas. The Plan seeks to transform the 9th Ward as it is rebuilt. The proposed transformation will be resident-driven and will provide improved employment opportunities, better education programs as well as greater access to healthcare, childcare and numerous other community services.U of I OnlyPermission not grante
The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-Selectin (CD62E) and P-Selectin (CD62P) in severe porcine pancreatitis
Inflammatory cytokines have been shown to
mediate organ damage by their action on vascular
endothelia and leukocytes, in part by upregulating the
expression of adhesion molecules, which in turn convey
transmigration of leukocytes into tissue.
The upregulation and activation of vascular cell
adhesion molecules on the endothelial cells avail firm
leukocyte adhesion to the vascular endothelium and
enhance their transmigration and consecutive tissue
injury. The aim of this study was to evaluate the
expresion of vascular adhesion molecules CD 31
(PECAM-1), CD 106 (VCAM-1), CD 62E (E-Selectin)
and CD 62P (P-Selectin) in the pancreas and distant
organs of pigs suffering from acute necrotizing
pancreatitis (AP).
AP was induced in 13 pigs by a combination of
intravenous cerulein and intraductal glycodeoxycholic
acid. For immunostaining of vascular adhesion
molecules slides of porcine pancreas, lung, kidney and
liver tissue were stained with monoclonal antibodies
(Ab) against PECAM-1-1, VCAM-1 E- and PSELECTIN.
The endothelial cell expression of CD 31 (PECAM-
1), CD 106 (VCAM), CD 62E (E-Selectin) and CD 62P
(P-SELECTIN) in severe porcine pancreatitis is
detectable and upregulation is partly significantly
Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases
Background: Advanced gastric cancer with synchronous peritoneal metastases (GC-PM) is associated with a poor prognosis. Although cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a promising approach, only a limited number of Western studies exist. Aim: To investigate the clinicopathological outcomes of patients who underwent CRS-HIPEC for GC-PM. Methods: A retrospective analysis of patients with GC-PM was conducted. All patients were seen at the Department of General and Visceral Surgery, Hospital Barmherzige Brüder, Regensburg, Germany between January 2011 and July 2021 and underwent CRS-HIPEC. Preoperative laboratory results, the use of neoadjuvant trastuzumab, and the details of CRS-HIPEC, including peritoneal carcinomatosis index, completeness of cytoreduction, and surgical procedures were recorded. Disease-specific (DSS), and overall survival (OS) of patients were calculated. Results: A total of 73 patients were included in the study. Patients treated with neoadjuvant trastuzumab (n = 5) showed longer DSS (P = 0.0482). Higher white blood cell counts (DSS: P = 0.0433) and carcinoembryonic antigen levels (OS and DSS: P < 0.01), and lower hemoglobin (OS and DSS: P < 0.05) and serum total protein (OS: P = 0.0368) levels were associated with shorter survival. Longer HIPEC duration was associated with more advantageous median survival times [60-min (n = 59): 12.86 mo; 90-min (n = 14): 27.30 mo], but without statistical difference. To obtain additional data from this observation, further separation of the study population was performed. First, propensity score-matched patient pairs (n = 14 in each group) were created. Statistically different DSS was found between patient pairs (hazard ratio = 0.2843; 95% confidence interval: 0.1119-0.7222; P = 0.0082). Second, those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity (median survival: 12.68 mo vs 24.02 mo), or had to undergo the procedure before 2016 (median survival: 12.68 mo vs 27.30 mo; P = 0.0493) were removed from the original study population. Conclusion: Based on our experience, CRS-HIPEC is a safe and secure method to improve the survival of advanced GC-PM patients. Prolonged HIPEC duration may serve as a good therapy for these patients