Multivariate-adjusted associations of selected energy-adjusted total nutrients with risk of breast cancer, 4-Corners Breast Cancer Study, 1999–2004.^a

<p>Abbreviations: OR, odds ratio; CI, confidence interval; No., number; mg, milligrams; mcg, microgram; g, gram,</p>a<p>The number of controls for each quartile is 609.</p>b<p>Models adjusted for age (continuous), center, and all variables shown in table.</p>c<p>In addition to the variables in model 1, models are further adjusted for ethnicity, education, body mass index, total MET hours per week, total energy intake per day, total daily fiber intake, cigarette status, alcohol intake, parity, family history, oral contraceptive use and menopausal status.</p>d<p>Some values were overlapped for presentation in table due to rounding.</p>e<p>Folate levels based on pre-fortification.</p

Mean dietary intake and total intake^a of folate, vitamin B₂, vitamin B₆, vitamin B₁₂ and methionine for cases and controls, stratified by ethnicity, 4-Corners Breast Cancer Study, 1999–2004.

<p>Abbreviations: DFE, dietary folate equivalents; SD, standard deviation; mg, milligrams; mcg, microgram; g, gram.</p>a<p>Dietary nutrient plus supplement. Supplement use based on participant report of multivitamins and minerals or other supplements.</p>b<p>Case-control comparison within ethnicity.</p>c<p>Significance test for differences between mean intakes adjusting for age, center, and total energy intake/day on logarithm transferred data.</p>d<p>Ethnic group comparison, regardless of case-control status.</p>e<p>Highlighted rows include dietary nutrient plus supplement.</p>f<p>Supplementation not applicable.</p

Characteristics of breast cancer cases and controls, stratified by ethnicity, 4-Corners Breast Cancer Study, 1999–2004.

<p>Abbreviations: SD, standard deviation; MET, metabolic equivalent of activity; gm, grams; kcal, kilocalories.</p>a<p>Case-control comparison within ethnicity using the Chi-square test for categorical variables and the <i>t</i> test for continuous variables.</p>b<p>Ethnic group comparison, regardless of case-control status, using the Chi-square test for categorical variables and the <i>t</i> test for continuous variables.</p>c<p>Education level. Missing data for 1 case and 1 control for non-Hispanic White women; 4 cases and 2 controls for Hispanics.</p>d<p>First degree of family history. Missing data for 20 cases and 24 controls for non-Hispanic White women; 14 cases and 19 controls for Hispanics.</p>e<p>Cigarette smoking status. Missing data for 1 case and 4 controls for non-Hispanic White women; 2 controls for Hispanics.</p>f<p>Oral contraceptive use within five years prior to referent year.</p>g<p>Menopausal status. Missing data for 3 cases for non-Hispanic White women; 2 cases and 3 controls for Hispanics.</p>h<p>Stage of tumor. Missing data for 34 for non-Hispanic White women; 12 for Hispanics.</p>i<p>Moderate/vigorous physical activity at referent year.</p

Percentage of lesions with abnormal FISH copy numbers according to case or control status (70 subjects).

*<p>Adjusted by multiple logistic regression for gender, age, center, and current smoking status.</p

Association between disease status and abnormal FISH marker (>2 copies per cell) for the top 4 markers (CEP3, <i>TP63</i>, CEP6, <i>MYC</i>).

*<p>Adjusted by multiple logistic regression for gender, age, center, current smoking status and histologic grade.</p

Distribution of lung cancer cases and controls according to demographic and histology variables.

<p>Distribution of lung cancer cases and controls according to demographic and histology variables.</p

Receiver operating characteristic curves describing the diagnostic prediction accuracy of three models, demographics alone (plain line, area under the curve (AUC) 73.4%), in combination with cytology (dashed line, AUC 86.6%) or demographics in combination with cytology and 4 FISH biomarker candidates (dotted line, AUC 92.6%).

<p>The demographic information represents gender, age, pack years smoking history, and smoking status.</p