A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.

Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started

Ethnic profiling in the Netherlands? A reflection on expanding preventive powers, ethnic profiling and a changing social and political context

Criminal Justice: Legitimacy, accountability, and effectivit

The relationship between the activities of different pools of RNA polymerases I and II during PHA-stimulation of human lymphocytes.

Following PHA-stimulation of lymphocytes in culture, it is known that nuclear RNA synthesis and the amount of extractable RNA polymerase activity rise in these cells. The relationship between these two phenomena has been examined. Using an in vitro assay system which discriminates between polymerase activity which is "engaged" in nuclear RNA synthesis and a pool of "free" enzyme, the data suggest that the factors regulating the interaction between these two pools of enzyme activity are different for forms I and II RNA polymerases

The Impact Of Neighborhood Context On Spatiotemporal Patterns Of Burglary

Objectives: Examine how neighborhoods vary in the degree to which they experience repeat/near repeat crime patterns and whether theoretical constructs representing neighborhood-level context, including social ecology and structural attributes, can explain variation in single incidents and those linked in space and time. Methods: Examine social, structural, and environmental design covariates from the American Community Survey to assess the context of near repeat burglary at the block group level. Spatially lagged negative binomial regression models were estimated to assess the relative contribution of these covariates on single and repeat/near repeat burglary counts. Results: Positive and consistent association between concentrated disadvantage and racial heterogeneity and all types of burglaries was evident, although the effects for other indicators, including residential instability, family disruption, and population density, varied across classifications of single and repeat/near repeat burglaries. Conclusions: Repeat/near repeat burglary patterns are conditional on the overall level and specific dimensions of disorganization, holding implications for offender-focused as well as community-focused explanations. This study contributes greater integration between the study of empirically observed patterns of repeats and community-based theories of crime, including collective efficacy