25 research outputs found
Theory of Two-Dimensional Josephson Arrays in a Resonant Cavity
We consider the dynamics of a two-dimensional array of underdamped Josephson
junctions placed in a single-mode resonant cavity. Starting from a well-defined
model Hamiltonian, which includes the effects of driving current and
dissipative coupling to a heat bath, we write down the Heisenberg equations of
motion for the variables of the Josephson junction and the cavity mode,
extending our previous one-dimensional model. In the limit of large numbers of
photons, these equations can be expressed as coupled differential equations and
can be solved numerically. The numerical results show many features similar to
experiment. These include (i) self-induced resonant steps (SIRS's) at voltages
V = (n hbar Omega)/(2e), where Omega is the cavity frequency, and n is
generally an integer; (ii) a threshold number N_c of active rows of junctions
above which the array is coherent; and (iii) a time-averaged cavity energy
which is quadratic in the number of active junctions, when the array is above
threshold. Some differences between the observed and calculated threshold
behavior are also observed in the simulations and discussed. In two dimensions,
we find a conspicuous polarization effect: if the cavity mode is polarized
perpendicular to the direction of current injection in a square array, it does
not couple to the array and there is no power radiated into the cavity. We
speculate that the perpendicular polarization would couple to the array, in the
presence of magnetic-field-induced frustration. Finally, when the array is
biased on a SIRS, then, for given junction parameters, the power radiated into
the array is found to vary as the square of the number of active junctions,
consistent with expectations for a coherent radiation.Comment: 11 pages, 8 eps figures, submitted to Phys. Rev
Row-switched states in two-dimensional underdamped Josephson junction arrays
When magnetic flux moves across layered or granular superconductor
structures, the passage of vortices can take place along channels which develop
finite voltage, while the rest of the material remains in the zero-voltage
state. We present analytical studies of an example of such mixed dynamics: the
row-switched (RS) states in underdamped two-dimensional Josephson arrays,
driven by a uniform DC current under external magnetic field but neglecting
self-fields. The governing equations are cast into a compact
differential-algebraic system which describes the dynamics of an assembly of
Josephson oscillators coupled through the mesh current. We carry out a formal
perturbation expansion, and obtain the DC and AC spatial distributions of the
junction phases and induced circulating currents. We also estimate the interval
of the driving current in which a given RS state is stable. All these
analytical predictions compare well with our numerics. We then combine these
results to deduce the parameter region (in the damping coefficient versus
magnetic field plane) where RS states can exist.Comment: latex, 48 pages, 15 figs using psfi
HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease
Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text