Rationale and study design of the prospective, longitudinal, observational cohort study “rISk strAtification in end-stage renal disease” (ISAR) study

Background: The ISAR study is a prospective, longitudinal, observational cohort study to improve the cardiovascular risk stratification in endstage renal disease (ESRD). The major goal is to characterize the cardiovascular phenotype of the study subjects, namely alterations in micro-and macrocirculation and to determine autonomic function. Methods/design: We intend to recruit 500 prevalent dialysis patients in 17 centers in Munich and the surrounding area. Baseline examinations include: (1) biochemistry, (2) 24-h Holter Electrocardiography (ECG) recordings, (3) 24-h ambulatory blood pressure measurement (ABPM), (4) 24 h pulse wave analysis (PWA) and pulse wave velocity (PWV), (5) retinal vessel analysis (RVA) and (6) neurocognitive testing. After 24 months biochemistry and determination of single PWA, single PWV and neurocognitive testing are repeated. Patients will be followed up to 6 years for (1) hospitalizations, (2) cardiovascular and (3) non-cardiovascular events and (4) cardiovascular and (5) all-cause mortality. Discussion/conclusion: We aim to create a complex dataset to answer questions about the insufficiently understood pathophysiology leading to excessively high cardiovascular and non-cardiovascular mortality in dialysis patients. Finally we hope to improve cardiovascular risk stratification in comparison to the use of classical and non-classical (dialysis-associated) risk factors and other models of risk stratification in ESRD patients by building a multivariable Cox-Regression model using a combination of the parameters measured in the study

Word length and frequency effects on children's eye movements during silent reading

AbstractIn the present study we measured the eye movements of a large sample of 2nd grade German speaking children and a control group of adults during a silent reading task. To be able to directly investigate the interaction of word length and frequency effects we employed controlled sentence frames with embedded target words in an experimental design in which length and frequency were manipulated independently of one another. Unlike previous studies which have investigated the interaction of word length and frequency effects in children, we used age-appropriate word frequencies for children. We found significant effects of word length and frequency for both children and adults while effects were generally greater for children. The interaction of word length and frequency was significant for children in gaze duration and total viewing time eye movement measures but not for adults. Our results suggest that children rely on sublexical decoding of infrequent words, leading to greater length effects for infrequent than frequent words while adults do not show this effect when reading children’s reading materials