Association of household income with a mutant p53 tumor status by estrogen receptor status.

<p>Association of household income with a mutant p53 tumor status by estrogen receptor status.</p

Kaplan-Meier survival curves for 5-year breast cancer-specific survival by annual household income (HI) of the patients.

<p>Log-rank test: <i>P</i> < 0.05. Within this follow-up period, 38 of the 173 patients (22%) died from breast cancer.</p

Association of patient characteristics with tumor p53 mutational status.

*<p><i>P</i> value comparing patient characteristics by tumor p53 mutational status</p>**<p>Cases with missing information are not included</p>***<p>Mann-Whitney rank sum test</p><p>Annual household income, race/ethnicity, and education are self-reported. Tumor-associated macrophages were counted as CD68-positive cells. Pack years: (packs smoked per day) x (years as a smoker). BMI  =  kg/m²; SD  =  standard deviation, IHC  =  immunohistochemistry.</p

Relationship between tumor p53 status and annual household income in the adjusted analysis.

<p>OR  =  odds ratio; CI  =  confidence interval; IHC  =  immunohistochemistry</p>*<p>Trend test. Shown is the OR for the stepwise increase in household income (reference: low income). Income coded as 0 (< $15,000), 1 ($15,000 to $60,000), and 2 (>$60,000); adjustments: smoking (pack years), age, and body mass index (BMI) were used as continuous data; other covariates were dichotomized for the analysis, as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057361#pone-0057361-t001" target="_blank">Table 1</a></p>**<p>adjusted for race/ethnicity, node status, tumor estrogen receptor status, and tumor grade</p