Outdoor Air Pollution and Arterial Hypertension

Air pollution is a major environmental risk factor. There is accumulating evidence that air pollution could induce elevated blood pressure and potentiate hypertension. Acute elevations in the outdoor air pollution levels can trigger immediate or shortly delayed increases in arterial blood pressure. Moreover, few studies suggest that short-term increases in the levels of particulate and gaseous pollutants could lead to an acute onset of hypertension. Prolonged exposure to outdoor air pollution is associated with elevated blood pressure. Furthermore, some longitudinal studies have linked long-term exposure to air pollution with the incidence of hypertension. Various components of air pollution, such as inhalable particulate matter (PM2.5, PM10), nitrogen oxides, sulfur dioxide, and ozone, have shown associations with blood pressure in some studies. The hypothesized underlying mechanisms include inflammatory reactions and oxidative stress in lungs and in systemic circulation, imbalance of autonomous nervous system, and pathologic changes in vascular endothelium. In addition to “traditional” susceptible groups such as elderly individuals or patients with chronic diseases, children and pregnant women could be especially susceptible to the adverse effects of air pollution. The interplay of air pollution with the related environmental exposures, such as traffic noise and climate change, should be investigated further

MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis

Wear of coated cutting tool based on AdvantEdge

Conference Name:2014 International Conference on Design, Manufacturing and Mechatronics, ICDMM 2014. Conference Address: Changsha, Hunan, China. Time:March 21, 2014 - March 23, 2014.Beijing Technology and Business University; Chengdu University; Hebei UniversityIn this paper, based on finite element simulation software AdvantEdge, the effects of different coating materials and thickness on the wear of cutting tools during the machining process have been studied. For the tools with coating materials of TiAlN, Al2O3, TiN, TiC, we can calculate the wear rate according to the Usui mathematical model of tool wear, and then consider thickness factor of TiC coating. Because of the lowest thermal conductivity, the workpiece cut by TiC coated tool will soften first and more over cutting time, it result in the lowest wear rate. And with the increase of coating thickness, the effect of "thermal barrier" is more obvious for the relatively thicker coating tool, but the relative sliding velocity between the chip and tool is increasing meanwhile, so a suitable coating thickness is necessary. ? (2014) Trans Tech Publications, Switzerland

Statistical analysis of dynamic properties of solid carbide end mill

Conference Name:2014 International Conference on Design, Manufacturing and Mechatronics, ICDMM 2014. Conference Address: Changsha, Hunan, China. Time:March 21, 2014 - March 23, 2014.Beijing Technology and Business University; Chengdu University; Hebei UniversityBy three-dimensional milling simulations of Aviation Aluminum 7050-T7451 with metal cutting finite element analysis software AdvantEdge FEM, milling force data was obtained and amplitude-frequency characteristics was achieved through Fourier transformation of milling forces. According to mathematical statistical analysis of milling force data, we illustrates that the high-speed milling is a multi-blade interrupted cutting process and the tool vibration is a random vibration. Correlation functions and power spectral density functions of milling force and displacement were calculated in terms of signal processing discipline. ? (2014) Trans Tech Publications, Switzerland

Parameter Optimization on the Uniflow Scavenging System of an OP2S-GDI Engine Based on Indicated Mean Effective Pressure (IMEP)

In this paper, an opposed-piston two-stroke (OP2S) gasoline direct injection (GDI) engine is introduced and its working principles and scavenging process were analyzed. An optimization function was established to optimize the scavenging system parameters, include intake port height, exhaust port height, intake port circumference ratio, the exhaust port circumference ratio and opposed-piston motion phase difference. The effect of the port height on the effective compression ratio and effective expansion ratio were considered, and indicated mean effective pressure (IMEP) was employed as the optimization objective instead of scavenging efficiency. Orthogonal experiments were employed to reduce the calculation work. The effect of the scavenging parameters on delivery ratio, trapping ratio, scavenging efficiency and indicated thermal efficiency were calculated, and the best parameters were also obtained by the optimization function. The results show that IMEP can be used as the optimization objective in the uniflow scavenging system; intake port height is the main factor to the delivery ratio, while exhaust port height is the main to engine trapping ratio, scavenging efficiency and indicated thermal efficiency; exhaust port height is the most important factor to effect the gas exchange process of OP2S-GDI engine