Characterization of Coupled Ground State and Excited State Equilibria by Fluorescence Spectral Deconvolution

Fluorescence probes with multiparametric response based on the relative variation in the intensities of several emission bands are of great general utility. An accurate interpretation of the system requires the determination of the number, positions and intensities of the spectral components. We have developed a new algorithm for spectral deconvolution that is applicable to fluorescence probes exhibiting a two-state ground-state equilibrium and a two-state excited-state reaction. Three distinct fluorescence emission bands are resolved, with a distribution of intensities that is excitation-wavelength-dependent. The deconvolution of the spectrum into individual components is based on their representation as asymmetric Siano-Metzler log-normal functions. The application of the algorithm to the solvation response of a 3-hydroxychromone (3HC) derivative that exhibits an H-bonding-dependent excited-state intramolecular proton transfer (ESIPT) reaction allowed the separation of the spectral signatures characteristic of polarity and hydrogen bonding. This example demonstrates the ability of the method to characterize two potentially uncorrelated parameters characterizing dye environment and interactions

Comparative efficacy of ace inhibitor spirapril in hypertensive patients from various age groups

The authors compared antihypertensive efficacy of spirapril (Quadropril®) in two age groups: patients with arterial hypertension (AH) aged under 55 or over 55 years. Analyzing 24-hour blood pressure (BP) monitoring data, the authors demonstrated that spirapril (Quadropril®) was more effective in younger age group, that manifested in greater BP reduction and improved circadian BP rhythm

Actual Question of Telecommunication Systems and Networks Research

<p> </p><div><div>This contribution aims to inform readers about topics of scientific research performed at the Department of Radioand Communication Engineering (Kafedra radiotechniki i elektrosvjazi), the Institute of Control Systems, Telecommunications and Electrification, Moscow State University of Communication Means (MIIT). The paper contains brief descriptions of papers written by PhD students of the given Department that are available at.</div></div><p> </p