Heat and cold waves trends in the Carpathian Region from 1961 to 2010

The past two decades of the 20th century and the first of the 21st century have been characterized by global temperature rise and increased frequency of weather-induced extreme events such as floods, droughts, heavy rainfall, and heat waves. We investigated the heat and the cold waves in the Carpathian Region, an area whose rich biosphere is endangered by extreme events. We used the daily minimum (T N ) and maximum (T X ) temperature data collected in the framework of the CARPATCLIM project. Such high-resolution (0.1∘ × 0.1∘) gridded data range from January 1961 to December 2010. In this study, a heat wave occurs when temperature is above the 90th percentile for at least five consecutive days and a cold wave occurs when temperature is below the 10th percentile for at least five consecutive days. The percentiles have been computed over the baseline period 1971 – 2000. We distinguish between night-time and daytime events and we discuss heat (and cold) waves considering at least five consecutive night and days with temperature above (below) the selected percentile. For each heat or cold wave event, we assigned duration, severity, and intensity. For these parameters and for frequency, we performed linear trend analysis for the period 1961 – 2010. The trends have been computed on an annual and seasonal basis and tested for statistical significance. Different spatial patterns of heat and cold waves characterize the Carpathian Region: heat wave events show general increase in all the parameters considered, while cold wave events show a decrease in all the variables West to the Carpathians and an increase North – East to the Carpathians. We also compiled a list of the most relevant heat waves that hit the Carpathian Region from 1961 to 2010: out of seven events, four occurred from 2000 to 2010. Instead, the 1960s and the 1980s have been the decades most hit by severe cold waves.JRC.H.7-Climate Risk Managemen

An overview of drought events in the Carpathian Region in 1961-2010

The Carpathians and their rich biosphere are considered to be highly vulnerable to climate change. Drought is one of the major climate-related damaging natural phenomena and in Europe it has been occurring with increasing frequency, intensity, and duration in the last decades. Due to climate change, land cover changes, and intensive land use, the Carpathian Region is one of the areas at highest drought risk in Europe. In order to analyze the drought events over the last 50 yr in the area, we used a 1961–2010 daily gridded temperature and precipitation dataset. From this, monthly 0.1 × 0.1 grids of four drought indicators (Standardized Precipitation-Evapotranspiration Index (SPEI), Standardized Precipitation Index (SPI), Reconnaissance Drought Indicator (RDI), and Palfai Aridity/Drought Index (PADI)) have been calculated. SPI, SPEI, and RDI have been computed at different time scales (3, 6, and 12 months), whilst PADI has been computed on an annual basis. The dataset used in this paper has been constructed in the framework of the CARPATCLIM project, run by a consortium of institutions from 9 countries (Austria, Croatia, Czech Republic, Hungary, Poland, Romania, Serbia, Slovakia, and Ukraine) with scientific support by the Joint Research Centre (JRC) of the European Commission. Temperature and precipitation station data have been collected, quality-checked, completed, homogenized, and interpolated on the 0.1 × 0.1 grid, and drought indicators have been consequently calculated on the grid itself. Monthly and annual series of the cited indicators are presented, together with high-resolution maps and statistical analysis of their correlation. A list of drought events between 1961 and 2010, based on the agreement of the indicators, is presented. We also discuss three case studies: drought in 1990, 2000, and 2003. The drought indicators have been compared both on spatial and temporal scales: it resulted that SPI, SPEI, and RDI are highly comparable, especially over a 12-month accumulation period. SPEI, which includes PET (Potential Evapo-Transpiration) as RDI does, proved to perform best if drought is caused by heat waves, whilst SPI performed best if drought is mainly driven by a rainfall deficit, because SPEI and RDI can be extreme in dry periods. According to PADI, the Carpathian Region has a sufficient natural water supply on average, with some spots that fall into the “mild dry” class, and this is also confirmed by the FAO-UNEP aridity index and the K¨oppen-Geiger climate classification.JRC.H.7-Climate Risk Managemen

An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance

Implementation of precision medicine in lung cancer has benefited from intense research in the past years, developing subsequently an improved quality of life and increased overall survival of the patients. Targeted therapy has become one of the most important therapeutic innovations for the non-small cell lung cancer (NSCLC) category with anaplastic lymphoma kinase (ALK) gene rearrangement. The aim of this review is to provide a through overview of the main molecules of ALK tyrosine kinase inhibitors (TKI) with their general and particular mechanisms of resistance, the main methods of ALK gene detection, each with advantages and limits and the future perspectives currently under research which try to overcome the mechanisms of resistance. We have used two of the most reliable medical databases EMBASE and PubMed to properly select the latest and the most relevant articles for this topic. Encouraged by the promising results, the clinical practice was enriched by the approval of tyrosine kinase inhibitor molecules, three generations being developed, each one with more powerful agents than the previous ones. Unfortunately, the resistance to TKI eventually occurs and it may be induced by several mechanisms, either known or unknown. Crizotinib was the most intensely studied TKI , becoming the first molecule approved into clinical practice and although four other drugs have been broadly used (alectinib, ceritinib, brigatinib and lorlatinib) it seems that even the most recently developed one remains imperfect due to the resistance mutations that developed. There are two types of resistance generally described for the entire class and for the particular drugs, but half of them remain unknown

Population and Conservation Status of Buxbaumia viridis (DC.) Moug. & Nestl. in Romania

The field survey made in the last 20 years revealed that large areas of Romania’s territory are still unexplored concerning moss distribution. The long-term research in natural and mature spruce forest habitats of this country shows that many sites are well protected, a status that is also confirmed by reports of Buxbaumia viridis. However, many other sites where this species was identified still lack legal protection. We also generated a potential distribution of the species based on an ensemble model, useful in guiding extensive field surveys and also management and conservation measures. In a country where the volume of wood cut by illegal logging is larger than the legal one, according to official data, it is very important that all habitats for B. viridis be included in protected areas. Our paper brings important data to aid in this goal

Lateral Cephalometric Analytical Uses for Temporomandibular Joint Disorders: The Importance of Cervical Posture and Hyoid Position

The temporomandibular joint disorder (TMD) is a syndrome that affects the masticatory muscles and temporomandibular joint (TMJ). Its pathophysiology is not yet fully known. Cephalometric analysis is used for routine evaluation regarding orthodontic treatment and other purposes. The aim of this study was to assess if using cephalometric analysis and TMJ conservative therapy to evaluate the hyoid bone position and the cervical posture reduced symptoms in adults with TMDs compared to no intervention. The authors conducted a systematic review of the literature (PubMed, Cochrane, Web of Science, Scopus, and Embase) for clinical studies of TMDs with conservative treatment and lateral cephalometric analysis of the hyoid and cervical posture. To assess the risk of bias for non-randomized clinical trials ROBINS-I tool was used. Out of 137 studies found, 6 remained to be included. Most of them found a link between TMD and lateral cephalometric analysis, but there was a high risk of bias. This review found a possible link between TMDs, the neck and cervical posture. There is a benefit reported regarding the use of the lateral cephalometry as a treatment, but more extensive prospective randomized clinical trials are necessary to be able to draw definitive conclusions

Climate of the Carpathian Region in the period 1961–2010: climatologies and trends of 10 variables

The Carpathians are the largest mountain range in Europe and they represent a geographic barrier between Central Europe, Eastern Europe, and the Balkans. In order to investigate the climate of the area, the CARPATCLIM project members compiled the Climate Atlas of the Carpathian Region, which consists of high-resolution daily grids (0.1˚ x 0.1˚) of sixteen meteorological variables and many derived indicators related to 1961-2010. We computed the gridded climatologies for 1961-2010 for eight variables (air pressure, cloudiness, precipitation, relative humidity, minimum and maximum temperature, sunshine duration, and wind speed) and we discuss their spatial patterns. For each variable, we calculated the gridded linear trends related to 1961-2010 both on annual and seasonal basis. In general, temperature was found to increase in every season in 1986-2010, confirming the trends occurring in Europe in the last decades. On the other way, wind speed decreased in every season. Cloudiness and relative humidity decreased in spring, summer, and winter, and increased in autumn, whilst sunshine duration, as expected, behaved in the opposite way. Precipitation slightly increased and air pressure showed no significant trend, except of a few grid points. Then, we dealt with the correlation between the variables: excluding the high elevation points, the most correlated are sunshine duration and temperature. In particular, positive and negative sunshine duration anomalies are found to be respectively correlated with positive and negative temperature anomalies during the global dimming (60’s and 70’s) and brightening (90’s and 2000’s) periods.JRC.H.7-Climate Risk Managemen

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care