Contrast-Enhanced HIFU Ablation Imaging.

<p>Representative ultrasound tumor images with and without intentionally incomplete HIFU ablation. A: Without HIFU ablation and without contrast enhancement. B: TTC-stained tumor that was not subjected to HIFU ablation. C: Contrast-enhanced ultrasound image of tumor without HIFU ablation. D: HIFU-ablated tumor without contrast enhancement. E: TTC-stained tumor that received HIFU ablation. F: Contrast-enhanced ultrasound image of tumor with HIFU ablation. The arrows indicate the ablated area. The scale bars represent 1cm.</p

Distribution of Doxorubicin in HIFU-ablated Tumor Tissue.

<p>Zero signifies the center of the implants, and the other numerical values refer to the radial distances from the center of the implants. A: Light microscopy image of cryosectioned tumor tissue. B: Fluorescence microscopy image of the same tumor tissue section. C: High-power image of the area in the white box shown in B. D: Fluorescent intensity. The asterisk (*) indicates the PLGA implant, the white arrow indicates the edge of the PLGA implant, and the yellow arrow indicates the distance from the edge. The scale bar represents 100μm.</p

In vitro Cumulative DOX Release (%).

<p>The data are presented as the means ± STDEV (the standard deviation, n = 3).</p