Association discovery and outlier detection of air pollution emissions from industrial enterprises driven by big data

ABSTRACTAir pollution is a major issue related to national economy and people's livelihood. At present, the researches on air pollution mostly focus on the pollutant emissions in a specific industry or region as a whole, and is a lack of attention to enterprise pollutant emissions from the micro level. Limited by the amount and time granularity of data from enterprises, enterprise pollutant emissions are still understudied. Driven by big data of air pollution emissions of industrial enterprises monitored in Beijing-Tianjin-Hebei, the data mining of enterprises pollution emissions is carried out in the paper, including the association analysis between different features based on grey association, the association mining between different data based on association rule and the outlier detection based on clustering. The results show that: (1) The industries affecting NOx and SO2 mainly are electric power, heat production and supply industry, metal smelting and processing industries in Beijing-Tianjin-Hebei; (2) These districts nearby Hengshui and Shijiazhuang city in Hebei province form strong association rules; (3) The industrial enterprises in Beijing-Tianjin-Hebei are divided into six clusters, of which three categories belong to outliers with excessive emissions of total VOCs, PM and NH3 respectively

Is Vertical Logistic Regression Privacy-Preserving? A Comprehensive Privacy Analysis and Beyond

We consider vertical logistic regression (VLR) trained with mini-batch gradient descent -- a setting which has attracted growing interest among industries and proven to be useful in a wide range of applications including finance and medical research. We provide a comprehensive and rigorous privacy analysis of VLR in a class of open-source Federated Learning frameworks, where the protocols might differ between one another, yet a procedure of obtaining local gradients is implicitly shared. We first consider the honest-but-curious threat model, in which the detailed implementation of protocol is neglected and only the shared procedure is assumed, which we abstract as an oracle. We find that even under this general setting, single-dimension feature and label can still be recovered from the other party under suitable constraints of batch size, thus demonstrating the potential vulnerability of all frameworks following the same philosophy. Then we look into a popular instantiation of the protocol based on Homomorphic Encryption (HE). We propose an active attack that significantly weaken the constraints on batch size in the previous analysis via generating and compressing auxiliary ciphertext. To address the privacy leakage within the HE-based protocol, we develop a simple-yet-effective countermeasure based on Differential Privacy (DP), and provide both utility and privacy guarantees for the updated algorithm. Finally, we empirically verify the effectiveness of our attack and defense on benchmark datasets. Altogether, our findings suggest that all vertical federated learning frameworks that solely depend on HE might contain severe privacy risks, and DP, which has already demonstrated its power in horizontal federated learning, can also play a crucial role in the vertical setting, especially when coupled with HE or secure multi-party computation (MPC) techniques

Proteomic and single-cell analysis shed new light on the anti-inflammatory role of interferonβ in chronic periodontitis

Periodontitis, a condition that results in periodontal attachment loss and alveolar bone resorption, contributes to the global burden of oral disease. The underlying mechanism of periodontitis involves the dysbiosis and dyshomeostasis between host and oral microbes, among which the macrophage is one of the major innate immune cell players, producing interferon β (IFNβ) in response to bacterial infection. The objective of this research was to examine the interaction of macrophages with periodontitis and the role and mechanism of IFNβ on macrophages. IFNβ has been shown to have the potential to induce the differentiation of M1 to M2 macrophages, which are stimulated by low levels of lipopolysaccharide (LPS). Additionally, IFNβ has been demonstrated to promote the production of ISG15 by macrophages, which leads to the inhibition of the innate immune response. Moreover, our investigation revealed that IFNβ has the potential to augment the secretion of ISG15 and its downstream cytokine, IL10, in LPS-stimulated macrophages. Single-cell analysis was conducted on the gingival tissues of patients with periodontitis, which revealed a higher proportion of macrophages in the periodontitis-diseased tissue and increased expression of IFNβ, ISG15, and IL10. Gene Set Enrichment Analysis indicated that bacterial infection was associated with upregulation of IFNβ, ISG15, and IL10. Notably, only IL10 has been linked to immunosuppression, indicating that the IFNβ-ISG15-IL10 axis might promote an anti-inflammatory response in periodontitis through IL10 expression. It is also found that macrophage phenotype transitions in periodontitis involve the release of higher levels of IFNβ, ISG15, and IL10 by the anti-inflammatory M2 macrophage phenotype compared to the pro-inflammatory M1 phenotype and myeloid-derived suppressor cells (MDSCs). This implies that the IFNβ-induced production of IL10 might be linked to the M2 macrophage phenotype. Furthermore, cell communication analysis demonstrated that IL10 can promote fibroblast proliferation in periodontal tissues via STAT3 signaling

Effects of Polystyrene Diet on the Growth and Development of Tenebrio molitor

In recent years, the role of Tenebrio molitor in degrading polystyrene foam through its gut microbes has become the focus of research. However, little literature has reported the effect of feeding on polystyrene foam on the growth and development of Tenebrio molitor. In this study, we investigated the impacts of different polystyrene by evaluating the vital signs of Tenebrio molitor fed in the intestines and excrement fluids using RNA-Seq t.echnology and then verifying the transcriptome sequencing findings using qRT-PCR technology. The average weight of Tenebrio molitor larvae in the wheat bran group increased significantly. Tenebrio molitor larvae in the PS group, on the other hand, didn’t grow as much and had a much lower average weight than those in the wheat bran group. Compared to the bran group, the excrement of Tenebrio molitor fed only on polystyrene foam was flaky and coarse, increased nitrogen and phosphorus atomic concentration ratios by about 50%, decreased potassium atomic concentration ratios by 63%, with the enterocytes and circular muscle of Tenebrio molitor falling as well. Kyoto Encyclopedia of Genes and Genomes enrichment indicated that the differential genes were mainly related to metabolic pathways. There was an agreement between qRT-PCR and RNA-Seq analyses for the growth and development genes chitinase, heat shock protein 70, and cytochrome P450. Only feeding polystyrene foam shall lead to the growth and development retardation of Tenebrio molitor

Toxic Effects of TiO₂ NPs on Zebrafish

Titanium dioxide nanoparticles (TiO2 NPs) have become a widely used nanomaterial due to the photocatalytic activity and absorption of ultraviolet light of specific wavelengths. This study investigated the toxic effects of rutile TiO2 NPs on zebrafish by examining its embryos and adults. In the embryo acute toxicity test, exposure to 100 mg/L TiO2 NPs didn’t affect the hatching rate of zebrafish embryos, and there was no sign of deformity. In the adult toxicity test, the effects of TiO2 NPs on oxidative damage in liver, intestine and gill tissue were studied. Enzyme linked immunosorbent assay (ELISA) and fluorescence-based quantitative real-time reverse transcription PCR (qRT-PCR) were used to detect the three antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione S transferase (GSTs) in the above mentioned zebrafish organs at protein and gene levels. The results showed that long-term exposure to TiO2 NPs can cause oxidative damage to organisms; and compared with the control group, the activity of the three kinds of enzyme declined somewhat at the protein level. In addition, long-term exposure to TiO2 NPs could cause high expression of CAT, SOD and GSTs in three organs of adult zebrafish in order to counter the adverse reaction. The effects of long-term exposure to TiO2 NPs to adult zebrafish were more obvious in the liver and gill

The complete mitochondrial DNA genome of a cone snail, Conus betulinus (Neogastropoda: Conidae), from the South China sea

The complete mitochondrial genome of the tubular cone snail Conus betulinus is presented in this study. The C. betulinus mitochondrial genome was 16,240 bp with 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes, and a non-coding AT-rich region (D-loop). The overall base composition was estimated to be 25.67% for A, 38.26% for T, 21.38% for G, and 14.69% for C, with a high A + T content of 63.93%. Phylogenetic analyses based on 13 PCGs showed the close relationship of vermivorous C. betulinus with the common ancestor of molluscivorous Conus textile and Conus gloriamaris, providing a basis for further studies on the phylogenetics of cone snails according to their dietary type

Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF

Bisphenol AF (BPAF) is extensively used as a raw material in industry, resulting in its widespread distribution in the aqueous environment. However, the effect of BPAF on the hypothalamic-pituitary-thyroidal (HPT) axis remains unknown. For elucidating the disruptive effects of BPAF on thyroid function and expression of the representative genes along the HPT axis in zebrafish (Danio rerio) embryos, whole-body total 3,3′,5-triiodothyronine (TT3), total 3,5,3′,5′-tetraiodothyronine (TT4), free 3,3′,5-triiodothyronine (FT3) and free 3,5,3′,5′-tetraiodothyronine (FT4) levels were examined following 168 h post-fertilization exposure to different BPAF concentrations (0, 5, 50 and 500 μg/L). The results showed that whole-body TT3, TT4, FT3 and FT4 contents decreased significantly with the BPAF treatment, indicating an endocrine disruption of thyroid. The expression of thyroid-stimulating hormone-β and thyroglobulin genes increased after exposing to 50 μg/L BPAF in seven-day-old larvae. The expressions of thyronine deiodinases type 1, type 2 and transthyretin mRNAs were also significantly up-regulated, which were possibly associated with a deterioration of thyroid function. However, slc5a5 gene transcription was significantly down-regulated at 50 μg/L and 500 μg/L BPAF exposure. Furthermore, trα and trβ genes were down-regulated transcriptionally after BPAF exposure. It demonstrates that BPAF exposure triggered thyroid endocrine toxicity by altering the whole-body contents of thyroid hormones and changing the transcription of the genes involved in the HPT axis in zebrafish larvae