Association between haplotypes of RET tagSNPs and susceptibility to thyroid cancer.

<p>Association between haplotypes of RET tagSNPs and susceptibility to thyroid cancer.</p

Functional prediction of seven tagSNPs of the RET gene.

<p>Functional prediction of seven tagSNPs of the RET gene.</p

Association between haplotypes of RET tagSNPs and the occurrence of distant metastasis in thyroid cancer.

<p>Association between haplotypes of RET tagSNPs and the occurrence of distant metastasis in thyroid cancer.</p

Association between RET tagSNP and clinicopathological features of thyroid cancer.

<p>Association between RET tagSNP and clinicopathological features of thyroid cancer.</p

Associations between <i>RET</i> tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer

<div><p>Background</p><p>It is unclear whether common genetic variants of the <i>RET</i> proto-oncogene contribute to disease susceptibility, clinical severity, and thyroid function in differentiated thyroid cancer (DTC).</p><p>Methods</p><p>A total of 300 DTC patients and 252 healthy controls were enrolled in this study. Seven RET tagging single nucleotide polymorphisms were genotyped using the KASPar platform.</p><p>Results</p><p>Subgroup analysis showed that concomitant thyroid benign diseases were less likely to occur in DTC subjects with the rs1799939 AG or AG plus AA genotypes (odds ratio (OR) = 1.93 and 1.88, P = 0.009 and 0.011, respectively). A rare haplotype, CGGATAA, was associated statistically with a reduced risk of DTC (OR = 0.18, P = 0.001). Concerning the aggressive features of DTC, higher level of N stage was more likely to occur in subjects carrying the wild-type genotypes at rs1800860 site (for dominant model: OR = 0.48, P = 0.008). Another rare haplotype, CAAGCGT, conferred increased risk for the occurrence of distant metastasis (OR = 7.57, P = 0.009). Notably, higher thyroid stimulating hormone levels and lower parathyroid hormone levels were found in patients with rs2075912, rs2565200, and rs2742240 heterozygotes and rare homozygotes; similar results were observed between PTH levels and rs1800858.</p><p>Conclusion</p><p>This study provided useful information on <i>RET</i> variants that should be subjected to further study.</p></div