Additional file 5: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

Parameters discussion. This file discusses the performance of MGOGP under different parameter settings. (DOCX 65 kb

Additional file 1: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

A step by step example of Rank Fusion process. This file provides an example of how to get the final gene rank. (DOCX 275 kb

Additional file 4: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

Final module list. This is the refined module list after removing irrelevant genes. (TXT 2736 kb

Additional file 7: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

Sourcecode. Some core code of our method. (TXT 5 kb

Additional file 3: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

Breast-Cancer-Gene. This is the known breast cancer-related genes downloaded from SNP4Disease. (TXT 2 kb

Additional file 2: of MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization

GSEA gene module. This file is all the gene modules downloaded from GSEA website. (TXT 2837 kb

Thermal Stability of Skyrmion Tubes in Nanostructured Cuboids

Magnetic skyrmions in bulk materials are typically regarded as two-dimensional structures. However, they also exhibit three-dimensional configurations, known as skyrmion tubes, that elongate and extend in-depth. Understanding the configurations and stabilization mechanism of skyrmion tubes is crucial for the development of advanced spintronic devices. However, the generation and annihilation of skyrmion tubes in confined geometries are still rarely reported. Here, we present direct imaging of skyrmion tubes in nanostructured cuboids of a chiral magnet FeGe using Lorentz transmission electron microscopy (TEM), while applying an in-plane magnetic field. It is observed that skyrmion tubes stabilize in a narrow field-temperature region near the Curie temperature (Tc). Through a field cooling process, metastable skyrmion tubes can exist in a larger region of the field-temperature diagram. Combining these experimental findings with micromagnetic simulations, we attribute these phenomena to energy differences and thermal fluctuations. Our results could promote topological spintronic devices based on skyrmion tubes

A Combination of Serological Assays to Detect Human Antibodies to the Avian Influenza A H7N9 Virus

<div><p>Human infection with avian influenza A H7N9 virus was first identified in March 2013 and represents an ongoing threat to public health. There is a need to optimize serological methods for this new influenza virus. Here, we compared the sensitivity and specificity of the hemagglutinin inhibition (HI), microneutralization (MN), and Western blot (WB) assays for the detection of human antibodies against avian influenza A (H7N9) virus. HI with horse erythrocytes (hRBCs) and a modified MN assay possessed greater sensitivity than turkey erythrocytes and the standard MN assay, respectively. Using these assays, 80% of tested sera from confirmed H7N9 cases developed detectable antibody to H7N9 after 21 days. To balance sensitivity and specificity, we found serum titers of ≥20 (MN) or 160 (HI) samples were most effective in determining seropositive to H7N9 virus. Single serum with HI titers of 20–80 or MN titer of 10 could be validated by each other or WB assay. Unlike serum collected from adult or elderly populations, the antibody response in children with mild disease was low or undetectable. These combinations of assays will be useful in case diagnosis and serologic investigation of human cases.</p></div

Spectrum of antibodies against influenza A H7N9 virus by along the days after illness onset.

<p>Forty-seven serum samples were collected from 36 patients with H7N9 infection between April 2nd and June 28th were tested by both horse erythorocytes hemagglutinin inhibition (hRBC HI), the modified microneutralization (MN) to detect H7-specific antibody.</p

Analysis of antibodies to H7N9 by age group.

<p>Abbreviations: HI, hemagglutination inhibition assay; MN, microneutralization assay; GMT: geometric mean titers.</p><p>Note: *, P<0.05 comparing with the GMT of the child group a and b values, respectively, according to <i>t</i>-tests.</p