Anisotropic Piezoelectric Properties of Porous (Ba_0.85Ca_0.15)(Zr_0.1Ti_0.9)O₃ Ceramics with Oriented Pores through TBA-Based Freeze-Casting Method

Porous (Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 (BCZT) piezoelectric ceramics with an oriented directional hole structure were prepared by using the tertbutyl alcohol (TBA)-based freeze-casting method. The influences of sintering temperatures on the microstructure and piezoelectric properties of porous BCZT ceramics were investigated both perpendicular and parallel to the freezing direction. With the increase in sintering temperatures and the porosities decreased from 58% to 42%, the compressive strength increased from 14.0 MPa to 25.0 MPa. In addition, the d33 value of 407 pC/N for the sample sintered at 1400 °C was obtained parallel to the freezing direction, which was 1.40 times that of the other direction

DataSheet_1_Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.zip

IntroductionVarious immunosuppressive regimens have been developed for the treatment of lupus nephritis (LN). This study aimed to compare the efficacy and safety of immunosuppressive regimens in adults with LN.MethodsWe systematically searched the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases, including conference proceedings, trial registries, and reference lists, from inception until July 10, 2022. The effects of treatment were compared and ranked using the surface under the cumulative ranking curve (SUCRA). The primary endpoint was total remission. The secondary endpoints were complete remission, systemic lupus erythematosus disease activity index (SLEDAI), relapse, all-cause mortality, end-stage renal disease (ESRD), infection, herpes zoster, ovarian failure, myelosuppression, and cancer.ResultsSixty-two trials reported in 172 studies involving 6,936 patients were included in the network meta-analysis. The combination of tacrolimus (TAC), mycophenolate mofetil (MMF), and glucocorticoid (GC) provided the best result for the total remission rate (SUCRA, 86.63%) and SLEDAI (SUCRA, 91.00%), while the combination of voclosporin (VCS) , MMF and GC gave the best improvement in the complete remission rate (SUCRA, 90.71%). The combination of cyclophosphamide (CYC), MMF and GC was associated with the lowest risk of relapse (SUCRA, 85.57%) and cancer (SUCRA, 85.14%), while the combination of obinutuzumab (OTB), MMF and GC was associated with the lowest risk of all-cause mortality (SUCRA, 84.07%). Rituximab (RTX) plus MMF plus GC was associated with the lowest risk of ESRD (SUCRA, 83.11%), while the risk of infection was lowest in patients treated with azathioprine (AZA) plus CYC plus GC (SUCRA, 68.59%). TAC plus GC was associated with the lowest risk of herpes zoster (SUCRA, 87.67%) and ovarian failure (SUCRA, 73.60%). Cyclosporine (CsA) plus GC was associated with the lowest risk of myelosuppression (SUCRA, 79.50%), while AZA plus GC was associated with the highest risk of myelosuppression (SUCRA, 16.25%).DiscussionThis study showed that a combination of TAC, MMF and GC was the best regimen for improving the total remission rate. The optimal regimen for specific outcomes should be highlighted for high-risk patients.</p

Additional file 3: Table S1. of Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis

Prevalence of malignancies in CREDIT at baseline. (DOC 39 kb

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22 janvier 18801880/01/22 (A9,N3057)-1880/01/22.Appartient à l’ensemble documentaire : PoitouCh