567 research outputs found
Fragments Intimes d'un Savant Oublié
Explicação do "ser matemático não arbitrário"
Posições sobre a história dos povos semitas.
Atitude perante a história da arte.
Poema de amor à Esposa
Modulated Chaos as a Source of Images for Numbers
Classificação de imagens de Markus-Lyapounof
Bethe lattice solution of a model of SAW's with up to 3 monomers per site and no restriction
In the multiple monomers per site (MMS) model, polymeric chains are
represented by walks on a lattice which may visit each site up to K times. We
have solved the unrestricted version of this model, where immediate reversals
of the walks are allowed (RA) for K = 3 on a Bethe lattice with arbitrary
coordination number in the grand-canonical formalism. We found transitions
between a non-polymerized and two polymerized phases, which may be continuous
or discontinuous. In the canonical situation, the transitions between the
extended and the collapsed polymeric phases are always continuous. The
transition line is partly composed by tricritical points and partially by
critical endpoints, both lines meeting at a multicritical point. In the
subspace of the parameter space where the model is related to SASAW's
(self-attracting self-avoiding walks), the collapse transition is tricritical.
We discuss the relation of our results with simulations and previous Bethe and
Husimi lattice calculations for the MMS model found in the literature.Comment: 25 pages, 9 figure
Sobre a precisão das estimativas de máxima verossimilhança nas distribuições bivariadas de valores extremos
Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoiddependent axial patterning in metazoans
Aldehyde dehydrogenases (ALDHs) catabolize toxic aldehydes and process the vitamin A-derived retinaldehyde into retinoic acid (RA), a small diffusible molecule and a pivotal chordate morphogen. In this study, we combine phylogenetic, structural, genomic, and developmental gene expression analyses to examine the evolutionary origins of ALDH substrate preference. Structural modeling reveals that processing of small aldehydes, such as acetaldehyde, by ALDH2, versus large aldehydes, including retinaldehyde, by ALDH1A is associated with small versus large substrate entry channels (SECs), respectively. Moreover, we show that metazoan ALDH1s and ALDH2s are members of a single ALDH1/2 clade and that during evolution, eukaryote ALDH1/2s often switched between large and small SECs after gene duplication, transforming constricted channels into wide opened ones and vice versa. Ancestral sequence reconstructions suggest that during the evolutionary emergence of RA signaling, the ancestral, narrow-channeled metazoan ALDH1/2 gave rise to large ALDH1 channels capable of accommodating bulky aldehydes, such as retinaldehyde, supporting the view that retinoid-dependent signaling arose from ancestral cellular detoxification mechanisms. Our analyses also indicate that, on a more restricted evolutionary scale, ALDH1 duplicates from invertebrate chordates (amphioxus and ascidian tunicates) underwent switches to smaller and narrower SECs. When combined with alterations in gene expression, these switches led to neofunctionalization from ALDH1-like roles in embryonic patterning to systemic, ALDH2-like roles, suggesting functional shifts from signaling to detoxification
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
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Estimatation of evapotranspiration and crop coefficient of melon cultivated in protected environment
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