Understanding the preferred role in infertility treatment decision making among Chinese infertile women in Hong Kong

Session 38: Managing patient expectations: no. O-140This free journal suppl. entitled: Abstract book of the 31st ESHRE Annual Meeting, Lisbon, Portugal, 14–17 June 2015STUDY QUESTION: What are the treatment decision making preferences in Chinese women undergoing fertility treatments in Hong Kong? ...postprin

Phenomenological scaling laws for ‘‘semidilute’’ macromolecule solutions from light scattering by optical probe particles

Polymer solution dynamics may be inferred from light scattering spectra of dissolved optical probe particles. We compare a variety of probes in solutions of several polymers. In the ‘‘overlapping’’ concentration/molecular weight regime, the Stokes–Einstein equation fails by up to a factor of 2, while the probe diffusion coefficient D follows a scaling law D/D0=exp(−aMγcνRδ) (c, M, and R are the polymer concentration, molecular weight, and the probe radius, respectively). Experimentally, γ=0.8±0.1, ν=0.6–1.0, and δ=−0.1 to 0, contrary to the theoretical predictions γ=0 and δ=1. With very high molecular‐weight polymers, we observe a further ‘‘entangled’’ regime, characterized by huge (104) failures of the Stokes–Einstein equation and the appearance of ‘‘fast’’ modes in the scattering spectrum.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70873/2/JCPSA6-82-11-5242-1.pd

Tamoxifen Initiation After Ductal Carcinoma In Situ

Endocrine therapy initiation after ductal carcinoma in situ (DCIS) is highly variable and largely unexplained. National guidelines recommend considering tamoxifen for women with estrogen receptor-positive (ER+) DCIS or who undergo excision alone. We evaluated endocrine therapy use after DCIS over a 15-year period in an integrated health care setting to identify factors related to initiation

Application of a Novel Algorithm for Expanding Newborn Screening for Inherited Metabolic Disorders across Europe

Inherited metabolic disorders (IMDs) are mostly rare, have overlapping symptoms, and can be devastating and progressive. However, in many disorders, early intervention can improve long-term outcomes, and newborn screening (NBS) programmes can reduce caregiver stress in the journey to diagnosis and allow patients to receive early, and potentially pre-symptomatic, treatment. Across Europe there are vast discrepancies in the number of IMDs that are screened for and there is an imminent opportunity to accelerate the expansion of evidence-based screening programmes and reduce the disparities in screening programmes across Europe. A comprehensive list of IMDs was created for analysis. A novel NBS evaluation algorithm, described by Burlina et al. in 2021, was used to assess and prioritise IMDs for inclusion on expanded NBS programmes across Europe. Forty-eight IMDs, of which twenty-one were lysosomal storage disorders (LSDs), were identified and assessed with the novel NBS evaluation algorithm. Thirty-five disorders most strongly fulfil the Wilson and Jungner classic screening principles and should be considered for inclusion in NBS programmes across Europe. The recommended disorders should be evaluated at the national level to assess the economic, societal, and political aspects of potential screening programmes

A whole-rock data set for the Skaergaard intrusion, East Greenland

We report a compilation of new and published whole-rock major and trace element analyses for 646 samples of the Skaergaard intrusion, East Greenland. The samples were collected in 14 stratigraphic profiles either from accessible and well-exposed surface areas or from drill core, and they cover most regions of the intrusion. This includes the Layered Series, the Upper Border Series, the Marginal Border Series and the Sandwich Horizon. The geochemical data were obtained by a combination of X-ray fluorescence and inductively coupled plasma mass spectrometry. This data set can, for example, be used to constrain processes of igneous differentiation and ore formation.

Retrospective Review of Positive Newborn Screening Results for Isovaleric Acidemia and Development of a Strategy to Improve the Efficacy of Newborn Screening in the UK

\ua9 2024 by the authors.Since the UK commenced newborn screening for isovaleric acidemia in 2015, changes in prescribing have increased the incidence of false positive (FP) results due to pivaloylcarnitine. A review of screening results between 2015 and 2022 identified 24 true positive (TP) and 84 FP cases, with pivalate interference confirmed in 76/84. Initial C5 carnitine (C5C) did not discriminate between FP and TP with median (range) C5C of 2.9 (2.0–9.6) and 4.0 (1.8–>70) \ub5mol/L, respectively, and neither did Precision Newborn Screening via Collaborative Laboratory Integrated Reports (CLIR), which identified only 1/47 FP cases. However, among the TP cases, disease severity showed a correlation with initial C5C in ‘asymptomatic’ individuals (n = 17), demonstrating a median (range) C5C of 3.0 (1.8–7.1) whilst ‘clinically affected’ patients (n = 7), showed a median (range) C5C of 13.9 (7.7–70) \ub5mol/L. These findings allowed the introduction of dual cut-off values into the screening algorithm to reduce the incidence of FPs, with initial C5C results ≥ 5 \ub5mol/L triggering urgent referral, and those >2.0 and <5.0 \ub5mol/L prompting second-tier C5-isobar testing. This will avoid delayed referral in babies at particular risk whilst reducing the FP rate for the remainder

Non-Local Configuration of Component Interfaces by Constraint Satisfaction

© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s10601-020-09309-y.Service-oriented computing is the paradigm that utilises services as fundamental elements for developing applications. Service composition, where data consistency becomes especially important, is still a key challenge for service-oriented computing. We maintain that there is one aspect of Web service communication on the data conformance side that has so far escaped the researchers attention. Aggregation of networked services gives rise to long pipelines, or quasi-pipeline structures, where there is a profitable form of inheritance called flow inheritance. In its presence, interface reconciliation ceases to be a local procedure, and hence it requires distributed constraint satisfaction of a special kind. We propose a constraint language for this, and present a solver which implements it. In addition, our approach provides a binding between the language and C++, whereby the assignment to the variables found by the solver is automatically translated into a transformation of C++ code. This makes the C++ Web service context compliant without any further communication. Besides, it uniquely permits a very high degree of flexibility of a C++ coded Web service without making public any part of its source code.Peer reviewe

PROSESS: a protein structure evaluation suite and server

PROSESS (PROtein Structure Evaluation Suite and Server) is a web server designed to evaluate and validate protein structures generated by X-ray crystallography, NMR spectroscopy or computational modeling. While many structure evaluation packages have been developed over the past 20 years, PROSESS is unique in its comprehensiveness, its capacity to evaluate X-ray, NMR and predicted structures as well as its ability to evaluate a variety of experimental NMR data. PROSESS integrates a variety of previously developed, well-known and thoroughly tested methods to evaluate both global and residue specific: (i) covalent and geometric quality; (ii) non-bonded/packing quality; (iii) torsion angle quality; (iv) chemical shift quality and (v) NOE quality. In particular, PROSESS uses VADAR for coordinate, packing, H-bond, secondary structure and geometric analysis, GeNMR for calculating folding, threading and solvent energetics, ShiftX for calculating chemical shift correlations, RCI for correlating structure mobility to chemical shift and PREDITOR for calculating torsion angle-chemical shifts agreement. PROSESS also incorporates several other programs including MolProbity to assess atomic clashes, Xplor-NIH to identify and quantify NOE restraint violations and NAMD to assess structure energetics. PROSESS produces detailed tables, explanations, structural images and graphs that summarize the results and compare them to values observed in high-quality or high-resolution protein structures. Using a simplified red–amber–green coloring scheme PROSESS also alerts users about both general and residue-specific structural problems. PROSESS is intended to serve as a tool that can be used by structure biologists as well as database curators to assess and validate newly determined protein structures. PROSESS is freely available at http://www.prosess.ca