163 research outputs found
Prospects and Problems Associated with Technological Change in Appellate Courts: Envisioning the Appeal of the Future
Prospects and Problems Associated with Technological Change in Appellate Courts: Envisioning the Appeal of the Future
The association between handwashing practices and illness symptoms among college students living in a university dormitory
http://deepblue.lib.umich.edu/bitstream/2027.42/61178/1/Thumma J, Aiello AE, Foxman B, The association between handwashing practices and illness symptoms among college students living in a university dormitory_2008.pd
Long-Term Survival after Gamma Knife Radiosurgery in a Case of Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature
The management of recurrent glioblastoma is highly challenging, and treatment outcomes remain uniformly poor. Glioblastoma is a highly infiltrative tumor, and complete surgical resection of all microscopic extensions cannot be achieved at the time of initial diagnosis, and hence local recurrence is observed in most patients. Gamma Knife radiosurgery has been used to treat these tumor recurrences for select cases and has been successful in prolonging the median survival by 8–12 months on average for select cases. We present the unique case of a 63-year-old male with multiple sequential recurrences of glioblastoma after initial standard treatment with surgery followed by concomitant external beam radiation therapy and chemotherapy (temozolomide). The patient was followed clinically as well as with surveillance MRI scans at every 2-3-month intervals. The patient underwent Gamma Knife radiosurgery three times for 3 separate tumor recurrences, and the patient survived for seven years following the initial diagnosis with this aggressive treatment. The median survival in patients with recurrent glioblastoma is usually 8–12 months after recurrence, and this unique case illustrates that aggressive local therapy can lead to long-term survivors in select situations. We advocate that each patient treatment at the time of recurrence should be tailored to each clinical situation and desire for quality of life and improved longevity
Clinical Outcomes of Gamma Knife Radiosurgery in the Treatment of Patients with Trigeminal Neuralgia
Since its introduction by Leksell, Gamma Knife radiosurgery (GKRS) has become increasingly popular as a management approach for patients diagnosed with trigeminal neuralgia (TN). For this reason, we performed a modern review of the literature analyzing the efficacy of GKRS in the treatment of patients who suffer from TN. For patients with medically refractory forms of the condition, GKRS has proven to be an effective initial and repeat treatment option. Cumulative research suggests that patients treated a single time with GKRS exhibit similar levels of facial pain control when compared to patients treated multiple times with GKRS. However, patients treated on multiple occasions with GKRS are more likely to experience facial numbness and other facial sensory changes when compared to patients treated once with GKRS. Although numerous articles have reported MVD to be superior to GKRS in achieving facial pain relief, the findings of these comparison studies are weakened by the vast differences in patient age and comorbidities between the two studied groups and cannot be considered conclusive. Questions remain regarding optimal GKRS dosing and targeting strategies, which warrants further investigation into this controversial matter
Catheter‐related Infection and Septicemia: Impact of Seasonality and Modifiable Practices from the DOPPS
Hemodialysis (HD) catheter‐related infection (CRI) and septicemia contribute to adverse outcomes. The impact of seasonality and prophylactic dialysis practices during high‐risk periods remain unexplored. This multicenter study analyzed DOPPS data from 12,122 HD patients (from 442 facilities) to determine the association between seasonally related climatic variables and CRI and septicemia. Climatic variables were determined by linkage to National Climatic Data Center of National Oceanic and Atmospheric Administration data. Catheter care protocols were examined to determine if they could mitigate infection risk during high‐risk seasons. Survival models were used to estimate the adjusted hazard ratio (AHR) of septicemia by season and by facility catheter dressing protocol. The overall catheter‐related septicemia rate was 0.47 per 1000 catheter days. It varied by season, with an AHR for summer of 1.46 (95% CI: 1.19–1.80) compared with winter. Septicemia was associated with temperature (AHR = 1.07; 95% CI: 1.02–1.13; p < 0.001). Dressing protocols using chlorhexidine (AHR of septicemia = 0.55; 95% CI: 0.39–0.78) were associated with fewest episodes of CRI or septicemia. Higher catheter‐related septicemia in summer may be due to seasonal conditions (e.g., heat, perspiration) that facilitate bacterial growth and compromise protective measures. Extra vigilance and use of chlorhexidine‐based dressing protocols may provide prophylaxis against CRI and septicemia.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102686/1/sdi12141.pd
Effect of population structure and kinship relationships on the results of association mapping tests of growth and wood quality traits in four Eucalyptus populations
Treatment patterns and survival in older adults with unresected nonmetastatic biliary tract cancers
Removal of cadmium and zinc from water using sewage sludge-derived biochar
© 2024 The Authors. Published by Elsevier B V. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.scenv.2024.100118This research reveals the adsorption of cadmium (Cd2+) and zinc (Zn+2) from water using sewage sludge-derived biochar pyrolysed at 700 °C (SSB). The morphology and particle characteristics of SSB were characterised through scanning electron microscopy (SEM), particle size distribution (PSD), fourier transform infrared (FTIR), X-ray diffraction (XRD), and X-ray fluorescence (XRF). The adsorption study showed that the optimum contact times for removing Zn2+ and Cd2+ were 80 and 140 minutes, respectively. 95.51% Zn2+ and 97.54% Cd2+ could be removed from spiked solutions featuring 50 mg/L of Zn2+ and 50 mg/L Cd2+, each treated with 25 g/L biochar. The optimum pH of the solutions was 8–9 at a temperature of 40°C, indicating some precipitation of the metal ions at an alkaline pH. The highest adsorption capacity of SSB for Cd2+ and Zn2+ was found to be 3.02 and 2.51 mg/g, respectively, which compares favourably with other adsorbents. The isotherm studies confirmed experimental data to closely follow the Langmuir isotherm model at an R2 value of 0.9846 and 0.9816 for Cd2+ and Zn2+, respectively. The kinetic study confirmed the physical interaction between the adsorbents and the adsorbate. The spontaneous and exothermic nature of the process was confirmed by negative values of change in Gibbs free energy (ΔG) and enthalpy (ΔH). SSB could be regenerated for 6 cycles. Overall, this study explores sustainability, recycling, and waste management by offering SSB as a potentially cost-effective and environment-friendly solution to remove Cd2+ and Zn2+ from water.Published versio
Abnormal RNA Stability in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA homeostasis, but it remains unclear whether RNA stability is affected in these disorders. We use Bru-seq and BruChase-seq to assess genome-wide RNA stability in ALS patient-derived cells, demonstrating profound destabilization of ribosomal and mitochondrial transcripts. This pattern is recapitulated by TDP-43 overexpression, suggesting a primary role for TDP-43 in RNA destabilization, and in postmortem samples from ALS and FTD patients. Proteomics and functional studies illustrate corresponding reductions in mitochondrial components and compensatory increases in protein synthesis. Collectively, these observations suggest that TDP-43 deposition leads to targeted RNA instability in ALS and FTD, and may ultimately cause cell death by disrupting energy production and protein synthesis pathways
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