Search for High Energy Skimming Neutrinos at a Surface Detector Array

In the present study we propose a new method for detectionof high energy cosmological muon neutrinos by transition radiations at amedium interface. The emerging electro-magnetic radiations induced by earth-skimming heavy charged leptons are able to trigger a few of aligned neighboringlocal water Cherenkov stations at  a surface detector array similar tothe Pierre Auger Observatory. The estimation applied tothe model of Gamma Ray Burst induced  neutrino fluxes and the spherical earth surface shows a competitive rate of muonneutrino events in the energy range below the GZK cut-off

Nanomaterial for Adjuvants Vaccine: Practical Applications and Prospects

Vaccines contain adjuvants to strengthen the immune responses of the receiver against pathogen infection or malignancy. A new generation of adjuvants is being developed to give more robust antigen-specific responses, specific types of immune responses, and a high margin of safety. By changing the physical and chemical properties of nanomaterials, it is possible to make antigen-delivery systems with high bioavailability, controlled and sustained release patterns, and the ability to target and image. Nanomaterials can modulate the immune system so that cellular and humoral immune responses more closely resemble those desired. The use of nanoparticles as adjuvants is believed to significantly improve the immunological outcomes of vaccination because of the combination of their immunomodulatory and delivery effects. In this review, we discuss the recent developments in new adjuvants using nanomaterials. Based on three main vaccines, the subunit, DNA, and RNA vaccines, the possible ways that nanomaterials change the immune responses caused by vaccines, such as a charge on the surface or a change to the surface, and how they affect the immunological results have been studied. This study aims to provide succinct information on the use of nanomaterials for COVID-19 vaccines and possible new applications

GeTe-TiC-C Composite Anodes for Li-Ion Storage

Germanium boasts a high charge capacity, but it has detrimental effects on battery cycling life, owing to the significant volume expansion that it incurs after repeated recharging. Therefore, the fabrication of Ge composites including other elements is essential to overcome this hurdle. Herein, highly conductive Te is employed to prepare an alloy of germanium telluride (GeTe) with the addition of a highly conductive matrix comprising titanium carbide (TiC) and carbon (C) via high-energy ball milling (HEBM). The final alloy composite, GeTe-TiC-C, is used as a potential anode for lithium-ion cells. The GeTe-TiC-C composites having different combinations of TiC are characterized by electron microscopies and X-ray powder diffraction for structural and morphological analyses, which indicate that GeTe and TiC are evenly spread out in the carbon matrix. The GeTe electrode exhibits an unstable cycling life; however, the addition of higher amounts of TiC in GeTe offers much better electrochemical performance. Specifically, the GeTe-TiC (20%)-C and GeTe-TiC (30%)-C electrodes exhibited excellent reversible cyclability equivalent to 847 and 614 mAh g−1 after 400 cycles, respectively. Moreover, at 10 A g−1, stable capacity retentions of 78% for GeTe-TiC (20%)-C and 82% for GeTe-TiC (30%)-C were demonstrated. This proves that the developed GeTe-TiC-C anodes are promising for potential applications as anode candidates for high-performance lithium-ion batteries

The efficacy of silver‐based electrospun antimicrobial dressing in accelerating the regeneration of partial thickness burn wounds using a porcine model

(1) Background: Wounds with damages to the subcutaneous are difficult to regenerate because of the tissue damages and complications such as bacterial infection. (2) Methods: In this study, we created burn wounds on pigs and investigated the efficacy of three biomaterials: polycaprolactone‐gelatin‐silver membrane (PCLGelAg) and two commercial burn dressings, Aquacel® Ag and UrgoTul™ silver sulfadiazine. In vitro long‐term antibacterial property and in vivo wound healing performance were investigated. Agar diffusion assays were employed to evaluate bacterial inhibition at different time intervals. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time‐kill assays were used to compare antibacterial strength among samples. Second‐degree burn wounds in the pig model were designed to evaluate the efficiency of all dressings in supporting the wound healing process. (3) Results: The results showed that PCLGelAg membrane was the most effective in killing both Gram‐positive and Gram-negative bacteria bacteria with the lowest MBC value. All three dressings (PCLGelAg, Aquacel, and UrgoTul) exhibited bactericidal effect during the first 24 h, supported wound healing as well as prevented infection and inflammation. (4) Conclusions: The results suggest that the PCLGelAg membrane is a practical solution for the treatment of severe burn injury and other infection‐related skin complications.</p

The Determinants of the Usage of Accounting Information Systems toward Operational Efficiency in Industrial Revolution 4.0: Evidence from an Emerging Economy

The purpose of this study is to determine the factors affecting the application of accounting information systems (AIS) in small and medium enterprises (SMEs) in Vietnam. Drawing upon the Technology&ndash;Organization&ndash;Environment (TOE) theoretical framework, Diffusion of Innovations theory (DOI), and Resource-based theory (RBV), we proposed a research model to investigate the antecedents and influence of AIS usage in Vietnamese SMEs. This study used an online survey of individuals who work in Vietnamese SMEs for data collection. The result was assembled by applying the PLS-SEM model to test the proposed hypotheses based on 132 valid responses. First, the factors that have a significant impact on AIS usage are as follows: relative advantage; owner/manager commitment; and impact of COVID-19. Second, the research results also confirm that there is a positive relationship between AIS usage and AIS effectiveness; AIS performance has a positive impact on business performance. Research implications are to help business owners and leaders decide whether to use AIS to strengthen the company&rsquo;s position and reduce the burden on departments, particularly the accounting department

Rise in alanine aminotransferase after HCV treatment is a highly sensitive screen for treatment failure

Nucleic acid testing to confirm sustained virological response (SVR) after HCV therapy is technical, often expensive, and frequently unavailable where disease prevalence is highest. Alternative surrogate biomarkers merit evaluation. In a short-treatment trial in Vietnam (SEARCH-1; n = 52) we analysed how changes in alanine transaminase (ΔALT) and aspartate transaminase (ΔAST), from end of treatment (EOT) to EOT + 12 weeks, related to SVR, defined as HCV RNA 0 IU/L was 98.1% (89.9 - 99.9%) sensitive and 35.8% (27.3 - 45.1%) specific. A rise in ALT or AST after HCV therapy is a highly sensitive screen for treatment failure in mild liver disease. This finding could reduce costs and complexity of managing HCV

Scalable Fabrication of Modified Graphene Nanoplatelets as an Effective Additive for Engine Lubricant Oil

The use of nano-additives is widely recognized as a cheap and effective pathway to improve the performance of lubrication by minimizing the energy loss from friction and wear, especially in diesel engines. In this work, a simple and scalable protocol was proposed to fabricate a graphene additive to improve the engine lubricant oil. Graphene nanoplates (GNPs) were obtained by a one-step chemical exfoliation of natural graphite and were successfully modified with a surfactant and an organic compound to obtain a modified GNP additive, that can be facilely dispersed in lubricant oil. The GNPs and modified GNP additive were characterized using scanning electron microscopy, X-ray diffraction, atomic force microscopy, Raman spectroscopy, and Fourier-transform infrared spectroscopy. The prepared GNPs had wrinkled and crumpled structures with a diameter of 10&ndash;30 &micro;m and a thickness of less than 15 nm. After modification, the GNP surfaces were uniformly covered with the organic compound. The addition of the modified GNP additive to the engine lubricant oil significantly enhanced the friction and antiwear performance. The highest reduction of 35% was determined for the wear scar diameter with a GNP additive concentration of approximately 0.05%. The mechanism for lubrication enhancement by graphene additives was also briefly discussed