A participatory physical and psychosocial intervention for balancing the demands and resources among industrial workers (PIPPI): study protocol of a cluster-randomized controlled trial

Background: Need for recovery and work ability are strongly associated with high employee turnover, well-being and sickness absence. However, scientific knowledge on effective interventions to improve work ability and decrease need for recovery is scarce. Thus, the present study aims to describe the background, design and protocol of a cluster randomized controlled trial evaluating the effectiveness of an intervention to reduce need for recovery and improve work ability among industrial workers. Methods/Design: A two-year cluster randomized controlled design will be utilized, in which controls will also receive the intervention in year two. More than 400 workers from three companies in Denmark will be aimed to be cluster randomized into intervention and control groups with at least 200 workers (at least 9 work teams) in each group. An organizational resources audit and subsequent action planning workshop will be carried out to map the existing resources and act upon initiatives not functioning as intended. Workshops will be conducted to train leaders and health and safety representatives in supporting and facilitating the intervention activities. Group and individual level participatory visual mapping sessions will be carried out allowing team members to discuss current physical and psychosocial work demands and resources, and develop action plans to minimize strain and if possible, optimize the resources. At all levels, the intervention will be integrated into the existing organization of work schedules. An extensive process and effect evaluation on need for recovery and work ability will be carried out via questionnaires, observations, interviews and organizational data assessed at several time points throughout the intervention period. Discussion: This study primarily aims to develop, implement and evaluate an intervention based on the abovementioned features which may improve the work environment, available resources and health of industrial workers, and hence their need for recovery and work ability

Transition from self-supported to supported living: Older people's experiences

To become dependent on professional support to accomplish the daily activities of life can be considered a turning point, involving a range of challenging changes in life. The purpose of the study was to describe the experiences of older home-dwelling individuals in transition from self-supported to supported living from a lifeworld perspective. Five women and five men were interviewed, and a descriptive phenomenological design was used. The findings showed that an attitude of acceptance was an essential characteristic for this group. An attitude of acceptance comprised: flexibility and tolerance, recognition and hopes, and valuation of self and situation. Finding themselves in a situation they had to submit to, they took an attitude of acceptance. An attitude of acceptance implied acknowledgement of the situation as well as positivity and desires to manage. This attitude may represent a significant potential for improvement. Awareness of this is crucial to support older individuals in a healthy way through the transition process. An attitude of acceptance, however, also implied an acceptance of discontinuity in their lives, renunciations, and denigration of own needs. But this aspect of the acceptance was trivialized by the participants and not equally obvious. Insight into this complexity is vital to avoid ignorance of older individuals’ vulnerability in the transition process

The Cosmic Telescope that Lenses the Sunburst Arc, PSZ1 G311.65-18.48: Strong Gravitational Lensing model and Source Plane Analysis

We present a strong lensing analysis of the cluster PSZ1 G311.65-18.48, based on Hubble Space Telescope imaging, archival VLT/MUSE spectroscopy, and Chandra X-ray data. This cool-core cluster (z=0.443) lenses the brightest lensed galaxy known, dubbed the "Sunburst Arc" (z=2.3703), a Lyman continuum (LyC) emitting galaxy multiply-imaged 12 times. We identify in this field 14 additional strongly-lensed galaxies to constrain a strong lens model, and report secure spectroscopic redshifts of four. We measure a projected cluster core mass of M(<250 kpc)=2.93+0.01/-0.02x10^14M_sun. The two least-magnified but complete images of the Sunburst Arc's source galaxy are magnified by ~13x, while the LyC clump is magnified by ~4-80x. We present time delay predictions and conclusive evidence that a discrepant clump in the Sunburst Arc, previously claimed to be a transient, is not variable, thus strengthening the hypothesis that it results from an exceptionally high magnification. A source plane reconstruction and analysis of the Sunburst Arc finds its physical size to be 1x2 kpc, and that it is resolved in three distinct directions in the source plane, 0, 40, and 75 degrees (east of North). We place an upper limit of r <~ 50 pc on the source plane size of unresolved clumps, and r<~ 32 pc for the LyC clump. Finally, we report that the Sunburst Arc is likely in a system of two or more galaxies separated by <~6 kpc in projection. Their interaction may drive star formation and could play a role in the mechanism responsible for the leaking LyC radiation.Comment: 31 pages, 14 figures, 4 tables. Submitted to Ap

Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac arrhythmia, suggesting new therapeutic targets for this diseas

Small Region, Big Impact: Highly Anisotropic Lyman-continuum Escape from a Compact Starburst Region with Extreme Physical Properties

Extreme, young stellar populations are considered the primary contributor to cosmic reionization. However, how Lyman-continuum (LyC) escapes these galaxies remains highly elusive because LyC escape can vary on sub-galactic scales that are technically challenging to observe in LyC emitters. We investigate the Sunburst Arc: a strongly lensed, LyC emitter at $z=2.37$. This galaxy reveals the exceptionally small scale (tens of parsecs) physics of LyC escape thanks to high magnification from strong lensing. Analyzing HST broadband and narrowband imaging, we find that the small ($<$100 pc) LyC leaking region shows distinctly extreme properties: a very blue UV slope ($\beta=-2.9\pm0.1$), high ionization state ([OIII]$\lambda 5007$/[OII]$\lambda 3727=11\pm3$ and [OIII]$\lambda 5007$/H$\beta=6.8\pm0.4$), strong oxygen emission (EW([OIII])$=1095\pm 40 \r{A}$), and high Lyman-$\alpha$ escape fraction ($0.3\pm 0.03$), none of which are found in any non-leaking regions of the galaxy. Moreover, a UV slope comparison with starburst population models indicates that the leaking region's UV emission consists of nearly ``pure'' stellar light with minimal contamination from surrounding nebular continuum emission and dust extinction. These results suggest a highly directional LyC escape such that LyC is produced and escapes from a small, extreme starburst region where the stellar feedback from an ionizing star cluster may create an anisotropic ``pencil beam'' viewing geometry in the surrounding gas. As a result, unabsorbed LyC directly escapes through these perforated hole(s). Importantly, such anisotropic escape processes imply that unfavorable sightline effects are a crucial contributor to the significant scatters between galaxy properties and LyC escape fraction in observations and that strong lensing uniquely reveals the small-scale physics that regulates the ionizing budget of galaxies for reionization.Comment: 17 pages, 5 figures, 3 tables, submitted to ApJ Letters. Comments welcom

Biomass Burning Plumes in the Vicinity of the California Coast: Airborne Characterization of Physicochemical Properties, Heating Rates, and Spatiotemporal Features

This study characterizes in situ airborne properties associated with biomass burning (BB) plumes in the vicinity of the California coast. Out of 231 total aircraft soundings in July–August 2013 and 2016, 81 were impacted by BB layers. A number of vertical characteristics of BB layers are summarized in this work (altitude, location relative to cloud top height, thickness, number of vertically adjacent layers, interlayer distances) in addition to differences in vertical aerosol concentration profiles due to either surface type (e.g., land or ocean) or time of day. Significant BB layer stratification occurred, especially over ocean versus land, with the majority of layers in the free troposphere and within 100 m of the boundary layer top. Heating rate profiles demonstrated the combined effect of cloud and BB layers and their mutual interactions, with enhanced heating in BB layers with clouds present underneath. Aerosol size distribution data are summarized below and above the boundary layer, with a notable finding being enhanced concentrations of supermicrometer particles in BB conditions. A plume aging case study revealed the dominance of organics in the free troposphere, with secondary production of inorganic and organic species and coagulation as a function of distance from fire source up to 450 km. Rather than higher horizontal and vertical resolution, a new smoke injection height method was the source of improved agreement for the vertical distribution of BB aerosol in the Navy Aerosol Analysis and Prediction System model when compared to airborne data