Magnetic properties of microtektites Semiannual status report, 1 Jan. - 31 Jun. 1969

Magnetic susceptibility, magnetization, and Curie constants for normal and bottle-green microtektites found in deep-sea sediment core

Reinforced structural plastics

Reinforced polyimide structures are described. Reinforcing materials are impregnated with a suspension of polyimide prepolymer and bonded together by heat and pressure to form a cured, hard-reinforced, polyimide structure

New rapid-curing, stable polyimide polymers with high-temperature strength and thermal stability

Additive-type polymerization reaction forms thermally stable polyimide polymers, thereby eliminating the volatile matter attendant with the condensation reaction. It is based on the utilization of reactive alicyclic rings positioned on the ends of polyimide prepolymers having relatively low molecular weights

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization

Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of cardiovascular disease. Patients with compromised cardiac function oftentimes have a state of chronic mild decreased oxygen at the level of the vasculature and organs, which has been shown to exacerbate ED. Hypoxia inducible factor (HIF) is a transcription factor complex shown to be the master regulator of the cellular response to decreased oxygen levels and many HIF target genes have been shown to be associated with ED. Methods Human endothelial and aortic smooth muscle cells were exposed either to A) normoxia (21% O2) for three weeks, or to B) mild decreased oxygen (15% O2) for three weeks to mimic blood oxygen levels in patients with heart failure, or to C) mild decreased oxygen for two weeks followed by one week of normoxia ("memory" treatment). Levels of HIF signaling genes (HIF-1α, HIF-2α, VEGF, BNIP3, GLUT-1, PAI-1 and iNOS) were measured both at the protein and mRNA levels. Results It was found that chronic exposure to mild decreased oxygen resulted in significantly increased HIF signaling. There was also a "memory" of HIF-1α and HIF target gene induction when oxygen levels were normalized for one week, and this "memory" could be interrupted by adding a small molecule HIF inhibitor to the last week of normalized oxygen. Finally, levels of ubiquitylated HIF-1α were reduced in response to chronic mild decreased oxygen and were not full restored after oxygen normalization. Conclusion These data suggest that HIF signaling may be contributing to the pathogenesis of endothelial dysfunction and that normalization of oxygen levels may not be enough to reduce vascular stress

Charge-Focusing Readout of Time Projection Chambers

Time projection chambers (TPCs) have found a wide range of applications in particle physics, nuclear physics, and homeland security. For TPCs with high-resolution readout, the readout electronics often dominate the price of the final detector. We have developed a novel method which could be used to build large-scale detectors while limiting the necessary readout area. By focusing the drift charge with static electric fields, we would allow a small area of electronics to be sensitive to particle detection for a much larger detector volume. The resulting cost reduction could be important in areas of research which demand large-scale detectors, including dark matter searches and detection of special nuclear material. We present simulations made using the software package Garfield of a focusing structure to be used with a prototype TPC with pixel readout. This design should enable significant focusing while retaining directional sensitivity to incoming particles. We also present first experimental results and compare them with simulation.Comment: 5 pages, 17 figures, Presented at IEEE Nuclear Science Symposium 201

Rigidity analysis of HIV-1 protease

We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor. Our study shows that the action of the inhibitors is to restrict the flexibility of the beta-hairpin flaps which allow access to the active site. The results are discussed in the context of full molecular dynamics simulations as well as data from NMR experiments.Comment: 4 pages, 3 figures. Conference proceedings for CMMP conference 2010 which was held at the University of Warwic

Floppy modes and the free energy: Rigidity and connectivity percolation on Bethe Lattices

We show that negative of the number of floppy modes behaves as a free energy for both connectivity and rigidity percolation, and we illustrate this result using Bethe lattices. The rigidity transition on Bethe lattices is found to be first order at a bond concentration close to that predicted by Maxwell constraint counting. We calculate the probability of a bond being on the infinite cluster and also on the overconstrained part of the infinite cluster, and show how a specific heat can be defined as the second derivative of the free energy. We demonstrate that the Bethe lattice solution is equivalent to that of the random bond model, where points are joined randomly (with equal probability at all length scales) to have a given coordination, and then subsequently bonds are randomly removed.Comment: RevTeX 11 pages + epsfig embedded figures. Submitted to Phys. Rev.