5,596 research outputs found
Magnetic properties of microtektites Semiannual status report, 1 Jan. - 31 Jun. 1969
Magnetic susceptibility, magnetization, and Curie constants for normal and bottle-green microtektites found in deep-sea sediment core
Reinforced structural plastics
Reinforced polyimide structures are described. Reinforcing materials are impregnated with a suspension of polyimide prepolymer and bonded together by heat and pressure to form a cured, hard-reinforced, polyimide structure
New rapid-curing, stable polyimide polymers with high-temperature strength and thermal stability
Additive-type polymerization reaction forms thermally stable polyimide polymers, thereby eliminating the volatile matter attendant with the condensation reaction. It is based on the utilization of reactive alicyclic rings positioned on the ends of polyimide prepolymers having relatively low molecular weights
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization
Background
Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of cardiovascular disease. Patients with compromised cardiac function oftentimes have a state of chronic mild decreased oxygen at the level of the vasculature and organs, which has been shown to exacerbate ED. Hypoxia inducible factor (HIF) is a transcription factor complex shown to be the master regulator of the cellular response to decreased oxygen levels and many HIF target genes have been shown to be associated with ED.
Methods
Human endothelial and aortic smooth muscle cells were exposed either to A) normoxia (21% O2) for three weeks, or to B) mild decreased oxygen (15% O2) for three weeks to mimic blood oxygen levels in patients with heart failure, or to C) mild decreased oxygen for two weeks followed by one week of normoxia ("memory" treatment). Levels of HIF signaling genes (HIF-1α, HIF-2α, VEGF, BNIP3, GLUT-1, PAI-1 and iNOS) were measured both at the protein and mRNA levels.
Results
It was found that chronic exposure to mild decreased oxygen resulted in significantly increased HIF signaling. There was also a "memory" of HIF-1α and HIF target gene induction when oxygen levels were normalized for one week, and this "memory" could be interrupted by adding a small molecule HIF inhibitor to the last week of normalized oxygen. Finally, levels of ubiquitylated HIF-1α were reduced in response to chronic mild decreased oxygen and were not full restored after oxygen normalization.
Conclusion
These data suggest that HIF signaling may be contributing to the pathogenesis of endothelial dysfunction and that normalization of oxygen levels may not be enough to reduce vascular stress
Charge-Focusing Readout of Time Projection Chambers
Time projection chambers (TPCs) have found a wide range of applications in
particle physics, nuclear physics, and homeland security. For TPCs with
high-resolution readout, the readout electronics often dominate the price of
the final detector. We have developed a novel method which could be used to
build large-scale detectors while limiting the necessary readout area. By
focusing the drift charge with static electric fields, we would allow a small
area of electronics to be sensitive to particle detection for a much larger
detector volume. The resulting cost reduction could be important in areas of
research which demand large-scale detectors, including dark matter searches and
detection of special nuclear material. We present simulations made using the
software package Garfield of a focusing structure to be used with a prototype
TPC with pixel readout. This design should enable significant focusing while
retaining directional sensitivity to incoming particles. We also present first
experimental results and compare them with simulation.Comment: 5 pages, 17 figures, Presented at IEEE Nuclear Science Symposium 201
Rigidity analysis of HIV-1 protease
We present a rigidity analysis on a large number of X-ray crystal structures
of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software
FIRST. We find that although the rigidity profile remains similar across a
comprehensive set of high resolution structures, the profile changes
significantly in the presence of an inhibitor. Our study shows that the action
of the inhibitors is to restrict the flexibility of the beta-hairpin flaps
which allow access to the active site. The results are discussed in the context
of full molecular dynamics simulations as well as data from NMR experiments.Comment: 4 pages, 3 figures. Conference proceedings for CMMP conference 2010
which was held at the University of Warwic
Floppy modes and the free energy: Rigidity and connectivity percolation on Bethe Lattices
We show that negative of the number of floppy modes behaves as a free energy
for both connectivity and rigidity percolation, and we illustrate this result
using Bethe lattices. The rigidity transition on Bethe lattices is found to be
first order at a bond concentration close to that predicted by Maxwell
constraint counting. We calculate the probability of a bond being on the
infinite cluster and also on the overconstrained part of the infinite cluster,
and show how a specific heat can be defined as the second derivative of the
free energy. We demonstrate that the Bethe lattice solution is equivalent to
that of the random bond model, where points are joined randomly (with equal
probability at all length scales) to have a given coordination, and then
subsequently bonds are randomly removed.Comment: RevTeX 11 pages + epsfig embedded figures. Submitted to Phys. Rev.
Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression
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