223 research outputs found
Обучение персонала как инструмент реализации стратегических целей на предприятиях нефтегазовой отрасли
Объектом исследования является система управления образовательным процессом и принятия решений. Целостная система подготовки персонала, включающая повышение квалификации кадров, рост мотивации, раскрытие потенциала работников, развитие производства, техническое обновление, формирование корпоративной культуры, является образовательной политикой общества ОАО «НК «Роснефть». Предметом исследования является образовательная деятельность открытого акционерного общества ОАО «НК «Роснефть». Цель работы - изучение теоретических и методологических подходов к проблеме обучения персонала, методов стимулирования и совершенствования системы обучения персонал, анализ практики обучения персонала на примере ОАО «НК» Роснефть». В данной выпускной работе были описаны методы симулирования и совершенствования системы обучения; рассмотрены теоретические аспекты обучения персонала на предприятии; изучен порядок работы по обучению персонала и систематизированы методы обучения; проанализированы процессы организационного обучения персонала в ОАО «НК» Роснефть» и влияние на эффективность работы организации.The object of study is the system of management of educational process and decision-making. A coherent system of staff training that includes skills development, increased motivation, potential employees, the development of production, technical renewal, formation of corporate culture is the educational policy of JSC "NK "Rosneft". The subject of research is the educational activities of open joint stock company OAO "NK "Rosneft". Purpose - study of theoretical and methodological approaches to the problem of personnel training, methods of stimulation and improvement of the teaching staff, analysis of the practice of personnel training on the example of JSC "NK" Rosneft". In this graduation work was described simulation and improvement of the system of education; theoretical aspects of personnel training at the enterprise; studied work arrangements for staff training and systematic teaching methods; analyzed the processes of organizational learning of staff of JSC "NK" Rosneft" and its influence on the efficiency of the organization
Electrocardiogram in an MRI Environment: Clinical Needs, Practical Considerations, Safety Implications, Technical Solutions and Future Directions
The MR-stethoscope: safe cardiac gating free of interference with electro-magnetic fields at 1.5 T, 3.0 T and 7.0 T
Применение метода аналитических сетей для оптимизации процесса выбора стратегии развития пассажирского автотранспортного предприятия
В статье обозначена проблема снижения рентабельности пассажирских автотранспортных предприятий и связанные с этим сложности по реализации процедуры стратегического прогнозирования и управления предприятием. Обосновано использование метода аналитических сетей в модели поддержки принятия решений при управлении стратегией автотранспортного предприятия, представленной в работе [1], в качестве инструмента, позволяющего формализовать экспертные знания на основных этапах оценки и выбора проектов стратегического развития. Описаны основные шаги и приведены результаты расчета алгоритма метода аналитических сетей в рамках данной модели.The article outlines the problem of reducing the profitability of passenger motor transport enterprises and the associated difficulties in implementing the procedure of strategic forecasting and enterprise management. The use of the method of analytical networks in the model of decision support in managing the strategy of a trucking enterprise presented in [1] is substantiated as a tool that allows to formalize expert knowledge at the main stages of evaluation and selection of projects for strategic development. The main steps and calculations of the algorithm algorithm for analytical networks within the framework of this model are described
Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation
The superparamagnetic iron oxide nanoparticle ferumoxytol is increasingly used
as intravascular contrast agent in magnetic resonance imaging (MRI). This
study details the impact of ferumoxytol on regulation of renal hemodynamics
and oxygenation. In 10 anesthetized rats, a single intravenous injection of
isotonic saline (used as volume control) was followed by three consecutive
injections of ferumoxytol to achieve cumulative doses of 6, 10, and 41 mg
Fe/kg body mass. Arterial blood pressure, renal blood flow, renal cortical and
medullary perfusion and oxygen tension were continuously measured. Regulation
of renal hemodynamics and oxygenation was characterized by dedicated
interventions: brief periods of suprarenal aortic occlusion, hypoxia, and
hyperoxia. None of the three doses of ferumoxytol resulted in significant
changes in any of the measured parameters as compared to saline. Ferumoxytol
did not significantly alter regulation of renal hemodynamics and oxygenation
as studied by aortic occlusion and hypoxia. The only significant effect of
ferumoxytol at the highest dose was a blunting of the hyperoxia-induced
increase in arterial pressure. Taken together, ferumoxytol has only marginal
effects on the regulation of renal hemodynamics and oxygenation. This makes
ferumoxytol a prime candidate as contrast agent for renal MRI including the
assessment of renal blood volume fraction
Physiological stress during cardiovascular magnetic resonance - handgrip exercise induced hemodynamic effects
physics considerations and electromagnetic field simulations up to 23.5 Tesla (1GHz)
Background Glioblastoma multiforme is the most common and most aggressive
malign brain tumor. The 5-year survival rate after tumor resection and
adjuvant chemoradiation is only 10 %, with almost all recurrences occurring in
the initially treated site. Attempts to improve local control using a higher
radiation dose were not successful so that alternative additive treatments are
urgently needed. Given the strong rationale for hyperthermia as part of a
multimodal treatment for patients with glioblastoma, non-invasive radio
frequency (RF) hyperthermia might significantly improve treatment results.
Methods A non-invasive applicator was constructed utilizing the magnetic
resonance (MR) spin excitation frequency for controlled RF hyperthermia and MR
imaging in an integrated system, which we refer to as thermal MR. Applicator
designs at RF frequencies 300 MHz, 500 MHz and 1GHz were investigated and
examined for absolute applicable thermal dose and temperature hotspot size.
Electromagnetic field (EMF) and temperature simulations were performed in
human voxel models. RF heating experiments were conducted at 300 MHz and 500
MHz to characterize the applicator performance and validate the simulations.
Results The feasibility of thermal MR was demonstrated at 7.0 T. The
temperature could be increased by ~11 °C in 3 min in the center of a head
sized phantom. Modification of the RF phases allowed steering of a temperature
hotspot to a deliberately selected location. RF heating was monitored using
the integrated system for MR thermometry and high spatial resolution MRI. EMF
and thermal simulations demonstrated that local RF hyperthermia using the
integrated system is feasible to reach a maximum temperature in the center of
the human brain of 46.8 °C after 3 min of RF heating while surface
temperatures stayed below 41 °C. Using higher RF frequencies reduces the size
of the temperature hotspot significantly. Conclusion The opportunities and
capabilities of thermal magnetic resonance for RF hyperthermia interventions
of intracranial lesions are intriguing. Employing such systems as an
alternative additive treatment for glioblastoma multiforme might be able to
improve local control by “fighting fire with fire”. Interventions are not
limited to the human brain and might include temperature driven targeted drug
and MR contrast agent delivery and help to understand temperature dependent
bio- and physiological processes in-vivo
Meeting Highlights of the 11th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance, Los Angeles, February 1–3, 2008
This paper features the most interesting presentations and discussions of the 2008 Annual Sessions of the Society for Cardiovascular Magnetic Resonance, which were held in Los Angeles from February 1 to 3, 2008
Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility
Cellular functions, ranging from focal adhesion (FA) dynamics and cell motility to tumour growth, are orchestrated by signals cells receive from outside via cell surface receptors. Signalling is fine-tuned by the exo-endocytic cycling of these receptors to control cellular responses such as FA dynamics, which determine cell motility. How precisely endocytosis regulates turnover of the various cell surface receptors remains unclear. Here we identify Stonin1, an endocytic adaptor of unknown function, as a regulator of FA dynamics and cell motility, and demonstrate that it facilitates the internalization of the oncogenic proteoglycan NG2, a co-receptor of integrins and platelet-derived growth factor receptor. Embryonic fibroblasts obtained from Stonin1-deficient mice display a marked surface accumulation of NG2, increased cellular signalling and defective FA disassembly as well as altered cellular motility. These data establish Stonin1 as a specific adaptor for the endocytosis of NG2 and as an important factor for FA dynamics and cell migration
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