Pulse wave velocity and lipids between GDM and non-GDM based on IADPSG and WHO criteria.

<p>^<b>1</b> Adjusted for age, BMI, and frequency of current and previous smokers.</p><p>Data are given as median (25^th, 75^th).</p><p>Comparison between women with GDM and non-GDM were performed using univariate general linear model on log transformed data.</p><p>Pulse wave velocity and lipids between GDM and non-GDM based on IADPSG and WHO criteria.</p

Predictors of PWV and TG/HDL ratio at 5-year follow-up based on GDM status in the index pregnancy using the WHO diagnostic criteria.

<p>^<b>1</b> Defined as primiparous (for the purposes of the 5-year follow-up)</p><p>^<b>2</b> Refers to both current and previous smokers</p><p>Predictors of PWV and TG/HDL ratio at 5-year follow-up based on GDM status in the index pregnancy using the WHO diagnostic criteria.</p

Relationship between measurements of glycemic control and vascular stiffness at 5-year follow-up in patients with (red circles) and without GDM (green circles) in the index pregnancy.

<p>(A) Associations between PWV, TG/HDL-C ratio and glucose levels during OGTT, HOMA-IR, insulin sensitivity and beta-cell function in the whole cohort at follow-up. (B) Interaction analysis between GDM (red) and indices of glucose metabolism on the TG/HDL ratio. (C) Interaction analysis between BMI and SBP and indices of glucose metabolism on the TG/HDL ratio.</p

MOESM1 of Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study

Additional file 1: Table S1. Plasma levels of PTX-3 and CRP during and after pregnancy in normal and GDM pregnancy according to IADSPSG criteria. Table S2. Univariate associations for increased CV risk as reflected by the apoB/apoA, LDL and TG/HDL-C ratios by PTX3, CRP and other CV risk factors at 5 years follow-up. Table S3. Multivariable adjusted models for increased CV risk as reflected by the apoB/apoA, LDL and TG/HDL-C ratios by PTX3 during pregnancy. The adjusted analysis included BMI and systolic BP acquired at the same time as the PTX3 measurement. Figure S1.  ROC curves of  ApoB/apoA and LDL/HDL-C during various time-points in pregnancy and CV risk at 5 years after pregnancy as reflected by the apoB/apoA ratio at 5 years follow-up

DataSheet_1_Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer.docx

IntroductionPersistent inflammation and immune activation in the lungs are associated with adverse outcomes such as radiation pneumonitis (RP) and poor survival in non-small-cell lung cancer (NSCLC) patients. However, it is unknown how this is reflected by leukocyte activation markers in serum.ObjectiveThe aim was to evaluate the serum levels of activation of different leukocyte subsets and to examine those in relation to the pathogenesis of RP and survival in NSCLC.MethodsWe analyzed the serum levels of MPO, sCD25, sTIM-3, sPD-L1, sCD14, sCD163, CCL19 and CCL21 in 66 inoperable NSCLC patients with stage IA-IIIA disease. The patients were treated with stereotactic body radiation therapy (SBRT) or concurrent chemoradiation therapy (CCRT), followed by regular blood sampling for 12 months after treatment and for 5 years for survival.ResultsNineteen (29%) patients developed RP, which occurred more frequently and earlier in patients receiving CCRT than in those receiving SBRT. Increases in sCD25, sTIM-3 and CCL21 levels were observed at the last 6 months of follow-up in patients who had RP after SBRT. Patients who had RP after CCRT had higher sTIM-3 levels during the first 3 months of follow-up. Baseline sCD25 was independently associated with both 2- and 5-year mortality outcomes, while baseline sTIM-3 was independently associated with 2-year mortality.ConclusionWe showed that T cell activation and exhaustion markers such as sCD25 and sTIM-3 are enhanced in patients developing RP and are associated with poor survival in NSCLC.</p

Associations between selected transcipts and clinical variables.

a<p>Univariate, Pearson correlation: r (p = ). <b>^b</b>Multivariate, Stepwise linear regression: B (SE), t = , p = . NA, not applicable.</p

The prevalence of vitamin D deficiency (serum 25-hydroxyvitamin D <30 nmol/L) and inadequacy (30–49 nmol) throughout the meteorological seasons.

<p>The numbers above the bars indicate the number of patients within the related vitamin D category (<i>P</i> = .021).</p

Kaplan-Meier plot of long-term survival for 241 patients discharged from hospital after treatment of community-acquired pneumonia, stratified by serum 25-hydroxyvitamin D levels measured at hospital admission (<i>P</i> = .261, by the log-rank test), and the corresponding mortality rates at the end of the follow-up period (bar chart).

<p>Abbreviations: NS, not significant. ^a One patient was lost to follow-up.</p

Demographic and clinical characteristics in 241 patients hospitalized for CAP, including stratification for vitamin D status.

<p>Demographic and clinical characteristics in 241 patients hospitalized for CAP, including stratification for vitamin D status.</p

Hazard ratios for the association between vitamin D status and long-term all-cause mortality before and after adjusting for confounders.

<p>Hazard ratios for the association between vitamin D status and long-term all-cause mortality before and after adjusting for confounders.</p