Coalbed Methane and Public Wildlands: How Much and at What Cost?

19 pages (includes color illustrations and maps). Contains references

Coalbed Methane and Public Wildlands: How Much and at What Cost?

19 pages (includes color illustrations and maps). Contains references

Analysis of data on the certificate of advanced graduate specialization program as collected by means of questionnaire

Thesis (Ed.M.)--Boston Universit

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No abstract available

U.S. Public Dairy Cattle Welfare Perceptions and Attitudes: Survey Summary

The U.S. dairy industry is facing pressure to assure and verify dairy cattle welfare related practices in response to societal concerns. This research aims to determine U.S. public’s attitudes and perceptions about dairy cattle welfare

Assessing Interconnections Between Wilderness and Adjacent Lands: The Grand Staircase-Escalante National Monument, Utah

Wilderness managers have traditionally managed wilderness lands based on the ecological and social content of wilderness areas. The authors propose a framework to systematically account for the biophysical, socioeconomic, and wildness characteristics of the broader landscape context. The method was applied to the proposed wilderness lands of the Grand Staircase-Escalante National Monument in southern Utah. The results illustrate patterns of interdependencies across the landscape. Spatial data demonstrate links between the integrity of proposed wilderness lands and the management of adjacent land units, and links between the economic health of local communities and the management of proposed wilderness and adjacent federal lands

Implementation of a risk mitigating COVID-adapted colorectal cancer pathway

No abstract available

Respiratory Infections during SARS Outbreak, Hong Kong, 2003

The effect of community hygienic measures during the outbreak of severe acute respiratory syndrome in Hong Kong was studied by comparing the proportion of positive specimens of various respiratory viruses in 2003 with those from 1998 to 2002. Community hygienic measures significantly reduced the incidence of various respiratory viral infections

Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men

<b>Objective</b> An epidemic of acute hepatitis C virus (HCV) infection in HIV-positive men-who-have-sex-with-men (MSM) is emerging in Europe, Australia and the USA. The aim of this study was to characterise the natural history of primary HCV in this setting and to assess host and viral factors which predict spontaneous clearance.<p></p> <b>Methods</b> This prospective longitudinal cohort study was carried out in 112 HIV-positive patients who were followed in a single centre (the St Mary's Acute HCV Cohort). Plasma and peripheral blood mononuclear cells (PBMCs) were obtained at monthly intervals for 3 months and at 3-monthly intervals thereafter for a median of 45 months (IQR=29–69 months). The primary end point was spontaneous clearance of HCV. Cox regression was used to assess the impact of clinical and virological variables on outcome, including liver function, CD4 count, rate of HCV RNA decline, T cell response and clonal sequence evolution within the HCV E2 envelope gene.<p></p> <b>Results</b> 15% of patients cleared HCV spontaneously, while 85% progressed towards chronicity. The latter group included a significant proportion of ‘fluctuating’ progressors (37.5%), in whom a fall followed by a rise (>1 log10) in viraemia was observed. This was associated with superinfection with new HCV strains and partially effective T cell responses. Spontaneous clearance was strongly associated with a 2.2 log10 viral load drop within 100 days of infection (HR=1.78; p<0.0001), elevated bilirubin (≥40 μmol/l; HR=5.04; p=0.006), elevated alanine aminotransferase (ALT; ≥1000 IU/ml; HR=2.62; p=0.048) and baseline CD4 count ≥650×106/l (HR=2.66; p=0.045), and only occurred in patients with genotype 1 infection. Evolution to spontaneous clearance occurred in patients with low viral diversity in the presence of an early multispecific T cell response.<p></p> <b>Conclusions</b> Spontaneous clearance of acute HCV in HIV-positive men can be predicted by a rapid decline in viral load, high CD4 count, elevated bilirubin and ALT, and is associated with low viral diversity and strong T cell responses