11,284 research outputs found

    Book Review: Religion in a New Key

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    A review of M. Darrol Bryant\u27s Religion in a New Key

    A Feminist Focus in Indian Painting

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    Supply Chain Managers and Risk Behavior: Testing the Sitkin and Pablo Model

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    The frequency of supply chain disruptions is increasing and the resulting costs amplify with the growth of supply chain density and complexity. Supply chain managers serve a pivotal role in ensuring continued firm competitiveness and success. Having the right person whose risk preferences, propensity to take risks, and history dealing with risks match the needs of the company is important. A foundational study performed by Sitkin and Pablo (1992) proposed a conceptual model focused on specific predictors of risk behavior from the individual, organizational, and problem-related perspectives. Questions still remain to the validity of the model given that it has not been fully tested. With the gaps in the current literature, the purpose of this study is to examine (1) does the Sitkin and Pablo (1992) model serve as a valid fit to measure supply chain manager’s propensity and perception of risk and (2) how does the managerial disruption perspective affects the risk perceptions/risk behavior relationship? The findings of the study will contribute to theoretical development through the expansion of the managerial disruption perspective on risk perceptions and through addressing the mediating relationship of risk propensity and risk perception on risk behaviors. Empirical testing is performed using a sample of supply chain managers with statistical analysis of the study results

    Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations.

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    Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and extreme weight loss. Pseudoatrophic brain changes are often readily visible in individual brain scans, and AN may be a valuable model disorder to study structural neuroplasticity. Structural magnetic resonance imaging studies have found reduced gray matter volume and cortical thinning in acutely underweight patients to normalize following successful treatment. However, some well-controlled studies have found regionally greater gray matter and persistence of structural alterations following long-term recovery. Findings from diffusion tensor imaging studies of white matter integrity and connectivity are also inconsistent. Furthermore, despite the severity of AN, the number of existing structural neuroimaging studies is still relatively low, and our knowledge of the underlying cellular and molecular mechanisms for macrostructural brain changes is rudimentary. We critically review the current state of structural neuroimaging in AN and discuss the potential neurobiological basis of structural brain alterations in the disorder, highlighting impediments to progress, recent developments, and promising future directions. In particular, we argue for the utility of more standardized data collection, adopting a connectomics approach to understanding brain network architecture, employing advanced magnetic resonance imaging methods that quantify biomarkers of brain tissue microstructure, integrating data from multiple imaging modalities, strategic longitudinal observation during weight restoration, and large-scale data pooling. Our overarching objective is to motivate carefully controlled research of brain structure in eating disorders, which will ultimately help predict therapeutic response and improve treatment

    Cloning of a Carcinoembryonic Antigen Gene Family Member Expressed in Leukocytes of Chronic Myeloid Leukemia Patients and Bone Marrow

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    The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin superfamily and can be subdivided into the CEA and pregnancy-specific glycoprotein subgroups. The basic structure of the encoded proteins consists of, in addition to a leader, one IgV-like and 2, 3, or 6 IgC-like domains. These domains are followed by varying COOH-terminal regions responsible for secretion, transmembrane anchoring, or insertion into the membrane by a glycosyl phosphatidylinositol tail. Here we report on the characterization of CGM6, a new member of the CEA gene subgroup, by complementary DNA cloning. The deduced coding region comprises 349 amino acids and consists of a leader, one IgV-like, two IgC-like domains, and a hydrophobic region, which is replaced by a glycosyl phosphatidylinositol moiety in the mature protein. CGM6 transcripts were only found thus far in leukocytes of chronic myeloid leukemia patients, in normal bone marrow, and in marginal amounts in normal granulocytes. The CGM6 gene product might, therefore, represent a myeloid marker. Analyses of CGM6 protein-expressing HeLa transfectants with monoclonal antibodies strongly indicate that the CGM6 gene codes for the CEA family member NCA-95

    Simulation tools for ultrasonic inspections of multi-layer armor panels

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    Some armor panels are fabricated from several layers of material including ceramics, graphite and∕or glass composites, and rubber. This multi‐layer makeup can complicate UT inspection, since many possible sound paths (including intra‐layer reverberations) can contribute to observed UT signals. At last year’s QNDE conference we reported on baseline property measurements (density, sound speed, attenuation, etc.) for the constituent layers of one prototype panel, and we discussed how that information was used to design an ultrasonic inspection to look for disbonding at interfaces. We now report on progress to develop better simulation tools for armor panel inspections. In particular we consider normal‐incidence pulse∕echo inspections and use a paraxial beam model to predict time‐domain signals for unflawed panels and those containing large delaminations. The model uses the frequency‐dependent baseline property data as inputs, and treats beam spread and focusing effects. We describe the modeling approach and present comparisons of model predictions to the experimental data gathered last year during inspections of five‐layer armor panels
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