Market Power after the Transition

Agribusiness, Financial Economics,

Induction of peripheral tolerance in ongoing autoimmune inflammation requires interleukin 27 signaling in dendritic cells

Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells. Interleukin (IL)-27 induces tolerogenic DCs and Treg cells; however, it is not known whether IL-27 is important for tolerance induction. We immunized wild-type (WT) and IL-27 receptor (WSX-1) knockout mice with MOG35-55 for induction of experimental autoimmune encephalomyelitis and intravenously (i.v.) injected them with MOG35-55 after onset of disease to induce i.v. tolerance. i.v. administration of MOG35-55 reduced disease severity in WT mice, but was ineffective in Wsx-/- mice. IL-27 signaling in DCs was important for tolerance induction, whereas its signaling in T cells was not. Further mechanistic studies showed that IL-27-dependent tolerance relied on cooperation of distinct subsets of spleen DCs with the ability to induce T cell-derived IL-10 and IFN-γ. Overall, our data show that IL-27 is a key cytokine in antigen-induced peripheral tolerance and may provide basis for improvement of antigen-specific tolerance approaches in multiple sclerosis and other autoimmune diseases. © 2017 Thom, Moore, Mari, Rasouli, Hwang, Yoshimura, Ciric, Zhang and Rostami

Saturated Critical Heat Flux in a Multi-Microchannel Heat Sink Fed by a Split Flow System

An extensive experimental campaign has been carried out for the measurement of saturated critical heat flux in a multi-microchannel copper heat sink. The heat sink was formed by 29 parallel channels that were 199 μm wide and 756 μm deep. In order to increase the critical heat flux and reduce the two-phase pressure drop, a split flow system was implemented with one central inlet at the middle of the channels and two outlets at either end. The base critical heat flux was measured using three HFC Refrigerants (R134a, R236fa and R245fa) for mass fluxes ranging from 250 to 1500 kg/m2 s, inlet subcoolings from −25 to −5 K and saturation temperatures from 20 to 50 °C. The parametric effects of mass velocity, saturation temperature and inlet subcooling were investigated. The analysis showed that significantly higher CHF was obtainable with the split flow system (one inlet–two outlets) compared to the single inlet–single outlet system, providing also a much lower pressure drop. Notably several existing predictive methods matched the experimental data quite well and quantitatively predicted the benefit of higher CHF of the split flow

Advanced superconducting magnets investigation

Mathematical models for steady state behavior of composite superconductors and experimental verification using magnet coi

Design study of superconducting magnets for a combustion magnetohydrodynamic (MHD) generator

Design trade off studies for 13 different superconducting magnet systems were carried out. Based on these results, preliminary design characteristics were prepared for several superconducting magnet systems suitable for use with a combustion driven MHD generator. Each magnet generates a field level of 8 T in a volume 1.524 m (60 in.) long with a cross section 0.254 m x 0.254 m (10 in. x 10 in.) at the inlet and 0.406 m x .406 m (16 in. x 16 in.) at the outlet. The first design involves a racetrack coil geometry intended for operation at 4.2 K; the second design uses a racetrack geometry at 2.0 K; and the third design utilizes a rectangular saddle geometry at 4.2 K. Each case was oriented differently in terms of MHD channel axis and main field direction relative to gravity in order to evaluate fabrication ease. All cases were designed such that the system could be disassembled to allow for alteration of field gradient in the MHD channel by changing the angle between coils. Preliminary design characteristics and assembly drawings were generated for each case

Two-Phase Cooling of Targets and Electronics for Particle Physics Experiments

An overview of the LTCM lab’s decade of experience with two-phase cooling research for computer chips and power electronics will be described with its possible beneficial application to high-energy physics experiments. Flow boiling in multi-microchannel cooling elements in silicon (or aluminium) have the potential to provide high cooling rates (up to as high as 350 W/cm2), stable and uniform temperatures of targets and electronics, and lightweight construction while also minimizing the fluid inventory. An overview of two-phase flow and boiling research in single microchannels and multi-microchannel test elements will be presented together with video images of these flows. The objective is to stimulate discussion on the use of two-phase cooling in these demanding applications, including the possible use of CO2

Fundamental issues, technology development and challenges of boiling heat transfer, critical heat flux and two-phase flow phenomena with nanofluids

This paper presents a comprehensive and critical review of studies on nucleate pool boiling heat transfer, flow boiling heat transfer, critical heat flux (CHF) and two-phase flow phenomena with nanofluids. First, general analysis of the available studies on the relevant topics is presented. Then, studies of physical properties of nanofluids are discussed. Next, boiling heat transfer, CHF phenomena and the relevant physical mechanisms are explored. Finally, future research needs have been identified according to the review and analysis. As the first priority, the physical properties of nanofluids have a significant effect on the boiling and CHF characteristics but the lack of the accurate knowledge of the physical properties has greatly limited the studies. Fundamentals of boiling heat transfer and CHF phenomena with Nanofluids have not yet been well understood. Flow regimes are important in understanding the boiling and CHF phenomena and should be focused on. Two phase pressure drops of nanofluids should also be studies. Furthermore, economic evaluation of the enhancement technology with nanofluid should be considered for the new heat transfer enhancement technology with nanofluids. Finally, applied research should be targeted to achieve an enabling practical heat transfer and CHF enhancement technology for engineering application with nanofluids

Prediction of flow boiling heat transfer of carbon dioxide inside small diameter tubes

Paper presented at the 5th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 1-4 July, 2007.This paper reviews recent experimental work on intube flow boiling of carbon dioxide and describes the updated flow boiling heat transfer model and flow pattern map proposed by Cheng, Ribatski, Wojtan and Thome [1] for evaporation of carbon dioxide in small diameter horizontal tubes. This new flow boiling heat transfer model predicted 76% of the CO2 database taken from the literature within ±30%. The new model and map are applicable to: tube diameters from 0.8 to 10 mm, mass velocities from 170 to 570 kg/m2s, heat fluxes from 5 to 32 kW/m2 and saturation temperatures from -28°C to 25°C (reduced pressures from 0.21 to 0.87). Simulations of the flow pattern map and heat transfer model are also shown.cs201