Spasm Rag

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Peig Sayers: Religious Subversions, Covert Withholdings, and Undaunted Mettle

The autobiography Peig A Scéal Féin (1936) inaugurated a new breakthrough in Blasket Island literature. Only a few years after its original publication, the autobiography was usurped as a teaching tool by the nascent Irish Republic being shaped by the De Valera government. A school edition, carefully edited and sanitized, was published in the 1940s and Peig became a textbook incorporated every third year as part of the school Leaving Certificate. As part of an effort to explode a patriarchal, sanitized myth, I want to reexamine the life story Peig in the context of Sayers’s larger oeuvre, including An Old Woman’s Reflections (1939), and radio presentations for the BBC (1947). A fuller appreciation of these written and oral performances reveals a hidden and much more intriguing Peig Sayers who saliently invalidates the stereotype on three fronts: creatively manipulating her religious heritage to serve her own egocentric and duplicitous ends; demonstrating a proclivity forprivacy that leads to strategic suppressions and covert maskings; contravening any image of pious docility when she repeatedly celebrates female rumbustious audacity and the pleasures of insurgency. The tales she selects to narrate, and her own actions within several stories, demonstrate an undaunted mettle as well as a predilection for passionate rebellion that should be spotlighted rather than suppressed or censored

The Design, Synthesis, and Investigation into Small Molecule Modulators of the Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (SHIP)

The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer\u27s disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 as a key secondary messenger in the transmission of signals from outside the cell to the nucleus. The SRC Homology 2 containing Inositol 5’-Phosphatase (SHIP) also plays a key role in the PI3K pathway, mediating hydrolysis of the inositol phospholipid PI(3,4,5)P3 to PI(3,4)P2. Early testing has shown modulation of SHIP activity through the use of small molecule modulators is effective at treating certain types of cancer and inflammatory diseases in cell-based assays and in murine xenografts.This report details the investigation into tryptamine-based pan-SHIP1/2 inhibitors, as well as studies into a newly discovered sulfonamide-based SHIP1 selective agonist. Attempts to modulate SHIP activity by means of small molecules led us to develop and synthesize various small molecule tryptamine inhibitors in hopes of increasing the selectivity and potency, as well as probe the structure-activity relationships. The recently uncovered bis-sulfonamide SHIP1 agonist was synthesized for preliminary testing and investigation. Additionally, studies were undertaken to design and synthesis new sulfonamide-based SHIP1 agonists allowing for the development of more potent agonists that are less likely to biodegrade when exposed to CYP enzymes