1 research outputs found
Fluorous Liquids for Magnetic Resonance-Based Thermometry with Enhanced Responsiveness and Environmental Degradation
Accurate temperature measurement via magnetic resonance
is valuable
for both in vitro and in vivo analysis
of local tissue for evaluating disease pathology and medical interventions. 1H MRI-based thermometry is used clinically but is susceptible
to error from magnetic field drift and low sensitivity in fatty tissue
and requires a reference for absolute temperature determination. As
an alternative, perfluorotributylamine (PFTBA), a perfluorocarbon
liquid for 19F MRI thermometry, is based on chemical shift
responsiveness and approaches the sensitivity of 1H MRI
thermometry agents; however, environmental persistence, greenhouse
gas concerns, and multiple resonances which can lead to MRI artifacts
indicate a need for alternative sensors. Using a 19F NMR-based
structure–property study of synthetic organofluorine molecules,
this research develops new organofluorine liquids with improved temperature
responsiveness, high signal, and reduced nonmagnetically equivalent
fluorine resonances. Environmental degradation analysis using reverse-phase
HPLC and quantitative 19F NMR demonstrates a rapid degradation
profile mediated via the aryl fluorine core of temperature sensors.
Our findings show that our lead liquid temperature sensor, DD-1, can be made in high yield in a single step and possesses an improved
responsiveness over our prior work and an 83% increase in aqueous
thermal responsiveness over PFTBA. Degradation studies indicate robust
degradation with half-lives of less than two hours under photolysis
conditions for the parent compound and formation of other fluorinated
products. The improved performance of DD-1 and its susceptibility
to environmental degradation highlight a new lead fluorous liquid
for thermometry applications