16 research outputs found
Antibody titers against the three vaccine strains at baseline (day 0), day 28 and day 84.
<p>Red lines indicate the mean of all volunteers of the antihelminthic treated group (AT) and blue lines indicate the mean of all participants of the placebo group. Dashed lines indicate antibody titers of each participant.</p
Study profile.
<p><sup>+</sup>Patients were excluded, because of infection with <i>S</i>. <i>haematobium</i>. *Participants not terminating the study are summarized as lost to follow up (n = 16).</p
Differences of HI titers between the respective visits (day 28, day 84) and day 0 (baseline).
<p>Red and blue colors represent the pre-treated (AT) and control group.</p
Vaccine specific IgA at day 0, day 28 and day 84 in antihelminthic treated (AT) (red) and placebo group (blue).
<p>Vaccine specific IgA at day 0, day 28 and day 84 in antihelminthic treated (AT) (red) and placebo group (blue).</p
Vaccine-specific IgG ASCs at day 0 and day 84, in antihelminthic treated (AT) and placebo group.
<p>Red and blue represent antihelminthic treated (AT) and control group.</p
Baseline characteristics and helminth infection at day -28.
<p>Baseline characteristics and helminth infection at day -28.</p
Distribution of the worm burden in the two groups at day 0 and day 84.
<p>Distribution of the worm burden in the two groups at day 0 and day 84.</p
Association between delayed anemia and increased white blood cell count at day 7.
<p>Individual white cell counts (WBC) on day 7 (D7) are presented as medians and interquartile ranges, divided into those who developed delayed anemia (12.8 × 10<sup>3</sup>/μl, interquartile range 9.6–17, <i>n</i> = 186) and those who did not (10.1 × 10<sup>3</sup>/μl, interquartile range 8.1–12.4, <i>n</i> = 689). Patients with delayed anemia had a significantly higher white blood cell count at day 7 (<i>p <</i> 0.001).</p
Kaplan–Meier plot for time to 90% parasite clearance in the per-protocol population.
<p>Time to 90% parasite clearance under parenteral ARS treatment is shown. Using the 10% delta at 24 h, both three-dose regimens are non-inferior to the five-dose regimen in a Cox proportional hazards model. The PP population has been used for the secondary endpoints.</p