465 research outputs found
Time variation of fundamental couplings and dynamical dark energy
Scalar field dynamics may give rise to a nonzero cosmological variation of
fundamental constants. Within different scenarios based on the unification of
gauge couplings, the various claimed observations and bounds may be combined in
order to trace or restrict the time history of the couplings and masses. If the
scalar field is responsible for a dynamical dark energy or quintessence,
cosmological information becomes available for its time evolution. Combining
this information with the time variation of couplings, one can determine the
interaction strength between the scalar and atoms, which may be observed by
tests of the Weak Equivalence Principle. We compute bounds on the present rate
of coupling variation from experiments testing the differential accelerations
for bodies with equal mass and different composition and compare the
sensitivity of various methods. In particular, we discuss two specific models
of scalar evolution: crossover quintessence and growing neutrino models.Comment: 26 pages, 2 figures; minor typos & added references, to be published
in JCA
Applying Deep Learning To Airbnb Search
The application to search ranking is one of the biggest machine learning
success stories at Airbnb. Much of the initial gains were driven by a gradient
boosted decision tree model. The gains, however, plateaued over time. This
paper discusses the work done in applying neural networks in an attempt to
break out of that plateau. We present our perspective not with the intention of
pushing the frontier of new modeling techniques. Instead, ours is a story of
the elements we found useful in applying neural networks to a real life
product. Deep learning was steep learning for us. To other teams embarking on
similar journeys, we hope an account of our struggles and triumphs will provide
some useful pointers. Bon voyage!Comment: 8 page
An Analysis of Private School Closings
We add to the small literature on private school supply by exploring exits of K-12 private schools. We find that the closure of private schools is not an infrequent event, and use national survey data from the National Center for Education Statistics to study closures of private schools. We assume that the probability of an exit is a function of excess supply of private schools over the demand, as well as the school's characteristics such as age, size, and religious affiliation. Our empirical results generally support the implications of the model. Working Paper 07-0
Towards Canonical Quantum Gravity for G1 Geometries in 2+1 Dimensions with a Lambda--Term
The canonical analysis and subsequent quantization of the (2+1)-dimensional
action of pure gravity plus a cosmological constant term is considered, under
the assumption of the existence of one spacelike Killing vector field. The
proper imposition of the quantum analogues of the two linear (momentum)
constraints reduces an initial collection of state vectors, consisting of all
smooth functionals of the components (and/or their derivatives) of the spatial
metric, to particular scalar smooth functionals. The demand that the
midi-superspace metric (inferred from the kinetic part of the quadratic
(Hamiltonian) constraint) must define on the space of these states an induced
metric whose components are given in terms of the same states, which is made
possible through an appropriate re-normalization assumption, severely reduces
the possible state vectors to three unique (up to general coordinate
transformations) smooth scalar functionals. The quantum analogue of the
Hamiltonian constraint produces a Wheeler-DeWitt equation based on this reduced
manifold of states, which is completely integrated.Comment: Latex 2e source file, 25 pages, no figures, final version (accepted
in CQG
Statefinder diagnosis and the interacting ghost model of dark energy
A new model of dark energy namely "ghost dark energy model" has recently been
suggested to interpret the positive acceleration of cosmic expansion. The
energy density of ghost dark energy is proportional to the hubble parameter. In
this paper we perform the statefinder diagnostic tool for this model both in
flat and non-flat universe. We discuss the dependency of the evolutionary
trajectories in and planes on the interaction parameter between
dark matter and dark energy as well as the spatial curvature parameter of the
universe. Eventually, in the light of SNe+BAO+OHD+CMB observational data, we
plot the evolutionary trajectories in and planes for the best fit
values of the cosmological parameters and compare the interacting ghost model
with other dynamical dark energy models. We show that the evolutionary
trajectory of ghost dark energy in statefinder diagram is similar to
holographic dark energy model. It has been shown that the statefinder location
of CDM is in good agreement with observation and therefore the dark
energy models whose current statefinder values are far from the CDM
point can be ruled out.Comment: 23 pages, 6 figure
The Turkey Ig-like receptor family: identification, expression and function.
The chicken leukocyte receptor complex located on microchromosome 31 encodes the chicken Ig-like receptors (CHIR), a vastly expanded gene family which can be further divided into three subgroups: activating CHIR-A, bifunctional CHIR-AB and inhibitory CHIR-B. Here, we investigated the presence of CHIR homologues in other bird species. The available genome databases of turkey, duck and zebra finch were screened with different strategies including BLAST searches employing various CHIR sequences, and keyword searches. We could not identify CHIR homologues in the distantly related zebra finch and duck, however, several partial and complete sequences of CHIR homologues were identified on chromosome 3 of the turkey genome. They were designated as turkey Ig-like receptors (TILR). Using cDNA derived from turkey blood and spleen RNA, six full length TILR could be amplified and further divided according to the typical sequence features into one activating TILR-A, one inhibitory TILR-B and four bifunctional TILR-AB. Since the TILR-AB sequences all displayed the critical residues shown to be involved in binding to IgY, we next confirmed the IgY binding using a soluble TILR-AB1-huIg fusion protein. This fusion protein reacted with IgY derived from various gallinaceous birds, but not with IgY from other bird species. Finally, we tested various mab directed against CHIR for their crossreactivity with either turkey or duck leukocytes. Whereas no staining was detectable with duck cells, the CHIR-AB1 specific mab 8D12 and the CHIR-A2 specific mab 13E2 both reacted with a leukocyte subpopulation that was further identified as thrombocytes by double immunofluorescence employing B-cell, T-cell and thrombocyte specific reagents. In summary, although the turkey harbors similar LRC genes as the chicken, their distribution seems to be distinct with predominance on thrombocytes rather than lymphocytes
Acceptability of OP/Na swabbing for SARS-CoV-2: a prospective observational cohort surveillance study in Western Australian schools
Objectives: When the COVID-19 pandemic was declared, Governments responded with lockdown and isolation measures to combat viral spread, including the closure of many schools. More than a year later, widespread screening for SARS-CoV-2 is critical to allow schools and other institutions to remain open. Here, we describe the acceptability of a minimally invasive COVID-19 screening protocol trialled by the Western Australian Government to mitigate the risks of and boost public confidence in schools remaining open. To minimise discomfort, and optimise recruitment and tolerability in unaccompanied children, a combined throat and nasal (OP/Na) swab was chosen over the nasopharyngeal swab commonly used, despite slightly reduced test performance. Design, setting and participants: Trialling of OP/Na swabbing took place as part of a prospective observational cohort surveillance study in 79 schools across Western Australia. Swabs were collected from 5903 asymptomatic students and 1036 asymptomatic staff in 40 schools monthly between June and September 2020. Outcome measures: PCR testing was performed with a two-step diagnostic and independent confirmatory PCR for any diagnostic PCR positives. Concurrent surveys, collected online through the REDCap platform, evaluated participant experiences of in-school swabbing. Results: 13 988 swabs were collected from students and staff. There were zero positive test results for SARS-CoV-2, including no false positives. Participants reported high acceptability: 71% of students reported no or minimal discomfort and most were willing to be reswabbed (4% refusal rate). Conclusions: OP/Na swabbing is acceptable and repeatable in schoolchildren as young as 4 years old and may combat noncompliance rates by significantly increasing the acceptability of testing. This kind of minimally-invasive testing will be key to the success of ongoing, voluntary mass screening as society adjusts to a new ‘normal’ in the face of COVID-19. Trial registration number: Australian New Zealand Clinical Trials Registry—ACTRN12620000922976
Newtonian Cosmology in Lagrangian Formulation: Foundations and Perturbation Theory
The ``Newtonian'' theory of spatially unbounded, self--gravitating,
pressureless continua in Lagrangian form is reconsidered. Following a review of
the pertinent kinematics, we present alternative formulations of the Lagrangian
evolution equations and establish conditions for the equivalence of the
Lagrangian and Eulerian representations. We then distinguish open models based
on Euclidean space from closed models based (without loss of generality)
on a flat torus \T^3. Using a simple averaging method we show that the
spatially averaged variables of an inhomogeneous toroidal model form a
spatially homogeneous ``background'' model and that the averages of open
models, if they exist at all, in general do not obey the dynamical laws of
homogeneous models. We then specialize to those inhomogeneous toroidal models
whose (unique) backgrounds have a Hubble flow, and derive Lagrangian evolution
equations which govern the (conformally rescaled) displacement of the
inhomogeneous flow with respect to its homogeneous background. Finally, we set
up an iteration scheme and prove that the resulting equations have unique
solutions at any order for given initial data, while for open models there
exist infinitely many different solutions for given data.Comment: submitted to G.R.G., TeX 30 pages; AEI preprint 01
Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease
Background- In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. Methods- Subjects were randomized to either community care or protocol provided scaling and root planing to evaluate effects on periodontal status and systemic levels of high-sensitivity Creactive protein (hs-CRP). Results- After 6 months, there was a significant reduction in mean probing depth and extent of 4- or 5-mm pockets. However, there were no significant differences in attachment levels, bleeding upon probing, or extent of subgingival calculus comparing subjects assigned to protocol therapy (n = 151) to those assigned to community care (n = 152). Using intent-to-treat analyses, there was no significant effect on serum hs-CRP levels at 6 months. However, 48% of the subjects randomized to community care received preventive or periodontal treatments. Secondary analyses demonstrated that consideration of any preventive or periodontal care (i.e., any treatment) compared to no treatment showed a significant reduction in the percentage of people with elevated hs-CRP (values >3 mg/l)at 6 months. However, obesity nullified the periodontal treatment effects on hs-CRP reduction. The adjusted odds ratio for hs-CRP levels >3 mg/l at 6 months for any treatment versus no treatment among non-obese individuals was 0.26 (95%confidence interval: 0.09 to 0.72), adjusting for smoking, marital status, and gender. Conclusion- This pilot study demonstrated the critical role of considering obesity as well as rigorous preventive and periodontal care in trials designed to reduce cardiovascular risk. Originally published Journal of Periodontology, Vol. 80, No. 2, Feb 200
DETECT schools study protocol: A prospective observational cohort surveillance study investigating the impact of COVID-19 in Western Australian schools
Introduction: Amidst the evolving COVID-19 pandemic, understanding the transmission dynamics of the SARS-CoV-2 virus is key to providing peace of mind for the community and informing policy-making decisions. While available data suggest that school-aged children are not significant spreaders of SARS-CoV-2, the possibility of transmission in schools remains an ongoing concern, especially among an aging teaching workforce. Even in low-prevalence settings, communities must balance the potential risk of transmission with the need for students\u27 ongoing education. Through the roll out of high-throughput school-based SARS-CoV-2 testing, enhanced follow-up for individuals exposed to COVID-19 and wellbeing surveys, this study investigates the dynamics of SARS-CoV-2 transmission and the current psychosocial wellbeing impacts of the pandemic in school communities. Methods: The DETECT Schools Study is a prospective observational cohort surveillance study in 79 schools across Western Australia (WA), Australia. To investigate the incidence, transmission and impact of SARS-CoV-2 in schools, the study comprises three “modules”: Module 1) Spot-testing in schools to screen for asymptomatic SARS-CoV-2; Module 2) Enhanced surveillance of close contacts following the identification of any COVID-19 case to determine the secondary attack rate of SARS-CoV-2 in a school setting; and Module 3) Survey monitoring of school staff, students and their parents to assess psycho-social wellbeing following the first wave of the COVID-19 pandemic in WA. Clinical Trial Registration: Trial registration number: ACTRN1262000092297
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