8 research outputs found
Additional file 1: of Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
Figures S5 to S7 Global immune-related adverse events (irAEs) with ipilimumab all dosage, 3 mg/kg, and 10 mg/kg for all grades and high grade. Figures S8 to S27 Organ-specific irAEs (endocrine, skin, gastrointestinal, and hepatic) for ipilimumab all dosage, 3 mg/kg, and 10 mg/kg and Tremelimumab, for all grades and high grade. Figures S28 to S31 Risk ratio of developing irAEs with ipilimumab at 10 mg/kg comparing with 3 mg/kg for organ-specific irAEs (gastrointestinal, skin, endocrine, and hepatic). Table S2 General characteristics of patients receiving anti-CTLA4 antibodies described in case reports. Table S3 Organ-specific irAEs. Table S4 Quality assessment. (DOCX 12329 kb
Additional file 1: of Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
Presenting search strategies. (DOC 201 kb
Distribution of BLK-rs13277113 and BANK1-rs3733197 multilocus genotypes in cases and control populations from Spain, France and Japan.
<p>Number of cases and controls, beta coefficient for logistic regression, corresponding p-value and risk category (“H” for high risk, “L” for low risk and “O” for unclassified) from Model Based Multifactor Dimensionality Reduction analysis for each multilocus genotype.</p
Epistasis between <i>BANK1</i> rs3733197 and <i>BLK</i> rs13277113 in rheumatoid arthritis: association of BANK rs3733197 G allele and BLK rs13277113 genotypes.
<p>Freq: frequency of the <i>BANK1</i> rs3733197 G risk allele, OR [95%CI]: odds ratio, 95% confidence interval.</p>*<p>France, Spain and Japan combined.</p
Epistasis between <i>BANK1</i> rs3733197 and <i>BLK</i> rs13277113.
<p>OR for trend for the G allele of <i>BANK1</i> rs3733197 and the three <i>BLK</i> rs13277113 genotypes by population (France, Spain and Japan).</p
Results of single marker analysis in populations genotyped for both <i>BANK1</i> and <i>BLK</i>.
<p>Number of cases and controls, frequency of G allele, odds ratio (OR) and 95% confidence interval (95% CI) and <i>P</i>-value of the association under a multiplicative model for each population separately, for European Caucasians and for the combined dataset (France, Spain and Japan).</p
Characteristics of rheumatoid arthritis cases investigated for a <i>BLK</i>–<i>BANK1</i> genetic interaction.
<p><i>Data are mean±SD or number (%) unless indicated.</i></p>*<p><i>Genotype data for the 3 investigated single nucleotide polymorphisms were available for 1,440 of 1,454 RA cases from France and Japan.</i></p>**<p><i>The percentage refers to percentage of positive patients among those with available data.</i></p
Meta-analysis of association of <i>BANK1</i> alleles and rheumatoid arthritis.
<p>Number of cases and controls; frequency of the G allele in cases and controls; and OR, 95% CI and <i>P</i>-value for the association for each population separately and for European Caucasians and non-European Caucasians and the combined dataset. All data were obtained from the literature, except for the France and Japan data, for which new genotyping was performed for this study.</p