The microbiome in patients with atopic dermatitis.

As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies

The KOMPACT-P study: Knee Osteoarthritis Management with Physiotherapy informed by Acceptance and Commitment Therapy—Pilot study protocol

Introduction: Incidence of total knee arthroplasty (TKA) is projected to rise 276% in 2030, and psychological distress affects up to 42% of people with knee osteoarthritis undergoing TKA, with demonstrated detrimental effects on postoperative outcomes. Few studies have assessed psychological treatment in people awaiting TKA, and these have been psychologist-delivered treatments. No evidence exists regarding psychologically-informed interventions delivered by health professionals currently embedded in TKA clinical pathways. The primary aim of this pilot study is to explore the safety, acceptability and feasibility of the Knee Osteoarthritis Management with Physiotherapy informed by Acceptance and Commitment Therapy (KOMPACT) approach in people awaiting TKA. Methods and analysis: 51 community-dwelling adults scheduled for a primary TKA at two hospitals will be recruited to this pilot, mixed-methods, prospective randomised controlled trial with assessor blinding. Participants will be randomised in a 1:2 ratio to either usual care (education class) or usual care plus KOMPACT (2 hours 20 min of preoperative physiotherapy informed by Acceptance and Commitment Therapy). Our primary outcome measures are safety (length of stay, complications and psychological health after KOMPACT), acceptability (treatment credibility and qualitative data) and feasibility (recruitment, retention and intervention fidelity) of the KOMPACT approach. Secondary outcomes include health service outcomes, patient-reported physical and psychological outcomes, and physical performance measures. Quantitative data collection was conducted at baseline, 1–2 weeks before TKA, 6 weeks after TKA and 6 months after TKA. Qualitative data collection is 1–2 weeks before TKA. Data analysis will take a quantitative-led approach with triangulation after thematic analysis of the qualitative data. Ethics and dissemination: This study has full ethics approval (HREC/18/WMEAD/440). Results from this study will be published in peer-reviewed journals and presented at local and international conferences. Trial registration number: Australia New Zealand Clinical Trials Registry (ACTRN12618001867280p)

Early warning system for shallow landslides using rainfall threshold and slope stability analysis

A combined cluster and regression analysis were performed for the first time to identify rainfall threshold that triggers landslide events in Amboori, Kerala, India. Amboori is a tropical area that is highly vulnerable to landslides. The 2, 3, and 5-day antecedent rainfall data versus daily rainfall was clustered to identify a cluster of critical events that could potentially trigger landslides. Further, the cluster of critical events was utilized for regression analysis to develop the threshold equations. The 5-day antecedent (x-variable) vs. daily rainfall (y-variable) provided the best fit to the data with a threshold equation of y = 80.7–0.1981x. The intercept of the equation indicates that if the 5-day antecedent rainfall is zero, the minimum daily rainfall needed to trigger the landslide in the Amboori region would be 80.7 mm. The negative coefficient of the antecedent rainfall indicates that when the cumulative antecedent rainfall increases, the amount of daily rainfall required to trigger monsoon landslide decreases. The coefficient value indicates that the contribution of the 5-day antecedent rainfall is ∼20% to the landslide trigger threshold. The slope stability analysis carried out for the area, using Probabilistic Infinite Slope Analysis Model (PISA-m), was utilized to identify the areas vulnerable to landslide in the region. The locations in the area where past landslides have occurred demonstrate lower Factors of Safety (FS) in the slope stability analysis. Thus, rainfall threshold analysis together with the FS values from slope stability can be suitable for developing a simple, cost-effective, and comprehensive early-warning system for shallow landslides in Amboori and similar regions

Prevalence of oral soft tissue lesions in Vidisha

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to determine the prevalence of oral soft tissue lesions in patients and to assess their clinicopathological attributes. 3030 subjects belonging to a semi-urban district of Vidisha in Central India were screened. Patients were examined with an overhead examination light and those who were identified with a questionable lesion underwent further investigations. Statistical analysis was done using the SPSS software.</p> <p>Findings</p> <p>8.4 percent of the population studied had one or more oral lesions, associated with prosthetic use, trauma and tobacco consumption. With reference to the habit of tobacco use, 635(21%) were smokers, 1272(42%) tobacco chewers, 341(11%) smokers and chewers, while 1464(48%) neither smoked nor chewed. 256 patients were found to have significant mucosal lesions. Of these, 216 cases agreed to undergo scalpel biopsy confirmation. 88 had leukoplakia, 21 had oral submucous fibrosis, 9 showed smoker's melanosis, 6 patients had lichen planus, 17 had dysplasia, 2 patients had squamous cell carcinoma while there was 1 patient each with lichenoid reaction, angina bullosa hemorrhagica, allergic stomatitis and nutritional stomatitis.</p> <p>Conclusions</p> <p>The findings in this population reveal a high prevalence of oral soft tissue lesions and a rampant misuse of variety of addictive substances in the community. Close follow up and systematic evaluation is required in this population. There is an urgent need for awareness programs involving the community health workers, dentists and allied medical professionals.</p

Introduction to the urban ecologies open collection: a call for contributions on methods, ethics, and design in geographical research with urban animals

This Open Collection proposes innovative research directions for both urban and beyond/more-than-/non-human geographies with animals. We are seeking papers for this Open Collection across three themes: (1) methods; (2) ethics and politics; and (3) planning and design. Specifically, we are interested in papers that pose questions of and reflect upon emergent tensions in researching with urban animals in each of these themes. This Open Collection aims to explore urban space beyond the human lens and to offer new modalities and frameworks for geographical research with urban animals. We are interested in papers that explore urban geographies with animals from a range of different theoretical, methodological, and empirical locations and perspectives. In this introduction to the Open Collection, we briefly summarise existing research in this field, before outlining the three thematic areas of the Collection

Microfluidic devices for photo-and spectroelectrochemical applications

The review presents recent developments in electrochemical devices for photo- and spectroelectrochemical investigations, with the emphasis on miniaturization (i.e., nanointerdigitated complementary metal-oxide-semiconductor devices, micro- and nano-porous silicon membranes or microoptoelectromechanical systems), silica glass/microreactors (i.e., plasmonic, Raman spectroscopy or optical microcavities) or polymer-based devices (i.e., 3D-printed, laser-engraved channels). Furthermore, we have evaluated inter alia the efficiency of various fabrication approaches for bioelectrochemical systems, biocatalysis, photochemical synthesis, or single nanoparticle spectroelectrochemistry. We envisioned the miniaturization of applied techniques such as cathodoluminescence, surface plasmon resonance, surface-enhanced Raman spectroscopy, voltametric and amperometric methods in the spectroelectrochemical microdevices. The research challenges and development perspectives of microfluidic, and spectroelectrochemical devices were also elaborated on.publishedVersio

Radio imaging of gravitationally lensed radio-quiet quasars

DATA AVAILABILITY : VLA data gathered for this project are publicly available on the VLA archive, which may be accessed at https://data.nrao.edu/ portal under project numbers 20B-309 (PI Jackson) and 23A-278 (PI Jackson).Please read abstract in the article.The Netherlands Organization for Scientific Research (NWO); the Chinese Academy of Sciences (CAS) and in part by the National Research Foundation of South Africa.https://academic.oup.com/mnrashj2024PhysicsNon