DIGITIZATION OF EDUCATION AND ITS SOCIO-ECONOMIC IMPACTS WITH SPECIAL REFERENCE TO TRIVANDRUM

This study is makes a comparative analysis of the rural-urban divide in digital education and examines the benefits and challenges of e-learning. A total of 124 respondents consisting of students, teachers and parents residing in the rural and urban areas of Trivandrum were surveyed using a well-structured questionnaire administered in both English and Malayalam. The sample population was identified through stratified random sampling. The study finds that disruption of internet connectivity due to signal unavailability is a major challenge of e-learning. Also, majority of the stakeholders were unwilling to make a conscious shift to a digitised education mode. Mostly students favoured online education because of its ease of usage, convenience, remote accessibility and system response speed. But most of the parents and teachers preferred offline education

Market entry strategy for German mittelstand medical device companies into the Indian market.

German medical devices companies are at the forefront of technology when it comes to innovation and R&D. Most of the European medical device manufacturing companies are located in Germany and the number of patents filed by these companies shows the amount of innovation in the industry. A majority of these medical devices are exported within the European Union countries. Economic slowdown combined with market saturation and increased competition makes Europe a very competitive market for these companies. Indian on the other hand is one of the fasted growing economies in the world. The Indian medical device sector is relatively an untapped markets for innovative medical devices. There are tremendous market opportunities due to the fact that local manufacturing base for medical devices are underdeveloped and often neglected. Most of the local Indian manufactures are engaged in producing basic medical devices and mostly into medical disposables and supplies. Around 70% of the medical devise sold in India are imported products. There is a huge demand and supply gap that is not being filled by the local manufacturers. India offers the perfect new market opportunity for German medical companies looking to venture into emerging new markets. There is abundant supplied of skilled manpower, with wages lower than that of the neighbouring China. India also has a rapidly growing middle class with increasing purchasing power. However, the regulations in the Indian medical device industry are not very clear and transparent. The Indian bureaucratic system is rampant with corruption and red tapes that needs to be tackled and navigated skilfully. A Germany company looking to enter the Indian market needs to understand that nothing in India can be implemented by a text book style entry strategy. In this thesis, we will analyse few of the most suitable entry strategies for German medical device companies with the advantages and disadvantages of each entry mode. We will also analyse the process of doing business in India, which requires an understanding of various aspect of the Indian culture and business relationship building in India. Further, we will analyse the current market scenario with a brief analyse of the local manufacturers currently in the market along with some information on foreign players in the market. Will also interview 5 experts from the medical field and look into few real case studies

Enhanced spectral resolution for correlated spectroscopic imaging using inner-product and covariance transform: a pilot analysis of metabolites and lipids in breast cancer in vivo.

Acquisition duration of correlated spectroscopy in vivo can be longer due to a large number of t1 increments along the indirect (F1) dimension. Limited number of t1 increments on the other hand leads to poor spectral resolution along F1. Covariance transformation (CT) instead of Fourier transform along t1 is an alternative way of increasing the resolution of the 2D COSY spectrum. Prospectively undersampled five-dimensional echo-planar correlated spectroscopic imaging (EP-COSI) data from ten malignant patients and ten healthy women were acquired and reconstructed using compressed sensing. The COSY spectrum at each voxel location was then generated using FFT, CT and a variant of CT called Inner Product (IP). Metabolite and lipid ratios were computed with respect to water from unsuppressed one-dimensional spectrum. The effects of t1-ridging artifacts commonly seen with FFT were not observed with CT/IP. Statistically significant differences were observed in the fat cross peaks measured with CT/IP/FFT. Spectral resolution was increased ~ 8.5 times (~ 19.53 Hz in FFT, ~ 2.32 Hz in CT/IP) without affecting the spectral width along F1 was possible with CT/IP. CT and IP enabled substantially increased F1 resolution effectively with significant gain in scan time and reliable measure of unsaturation index as a biomarker for malignant breast cancer

Enhanced spectral resolution for correlated spectroscopic imaging using inner-product and covariance transform: a pilot analysis of metabolites and lipids in breast cancer in vivo

Abstract Acquisition duration of correlated spectroscopy in vivo can be longer due to a large number of t1 increments along the indirect (F1) dimension. Limited number of t1 increments on the other hand leads to poor spectral resolution along F1. Covariance transformation (CT) instead of Fourier transform along t1 is an alternative way of increasing the resolution of the 2D COSY spectrum. Prospectively undersampled five-dimensional echo-planar correlated spectroscopic imaging (EP-COSI) data from ten malignant patients and ten healthy women were acquired and reconstructed using compressed sensing. The COSY spectrum at each voxel location was then generated using FFT, CT and a variant of CT called Inner Product (IP). Metabolite and lipid ratios were computed with respect to water from unsuppressed one-dimensional spectrum. The effects of t1-ridging artifacts commonly seen with FFT were not observed with CT/IP. Statistically significant differences were observed in the fat cross peaks measured with CT/IP/FFT. Spectral resolution was increased ~ 8.5 times (~ 19.53 Hz in FFT, ~ 2.32 Hz in CT/IP) without affecting the spectral width along F1 was possible with CT/IP. CT and IP enabled substantially increased F1 resolution effectively with significant gain in scan time and reliable measure of unsaturation index as a biomarker for malignant breast cancer

Furthering the precision of RUSLE soil erosion with PSInSAR data: an innovative model

Soil erosion is a severe environmental problem worldwide, especially in tropical regions. The Revised Universal Soil Loss Equation (RUSLE), one of the universally accepted empirical soil erosion models, is quite commonly used in tropical climatic conditions to estimate the magnitude and severity of soil erosion. This study, apart from identifying the role of individual parameters in influencing the results of the RUSLE, also aims at refining the RUSLE results by incorporating the state-of-the-art technique Persistent Scatterer Interferometric Synthetic Aperture Radar (PSInSAR) in a GIS environment by utilizing its ability to measure minute surface changes in millimetre levels. Apart from this novel approach of prioritising soil erosion classes using PSInSAR, the eroding surface conditions were also studied using low coherence value (\u3c0.75 in this study). The spatially and temporally averaged annual soil loss and net soil erosion (2015–2019), derived through RUSLE and transport limited sediment delivery (TLSD) approach, respectively, was improved by spatially integrating the PSInSAR velocity map. The integrated methodological framework is demonstrated for a tropical river basin in South India (Muvattupuzha River Basin [MRB]), which shows a mean rate of net soil loss of 6.8 ton/ha/yr, and nearly 8% of the area experiences deposition. Our approach to improve the accuracy of RUSLE-based soil erosion classes using PSInSAR techniques clearly demarcated the areas that call for utmost priority in implementing management practices. The corollary results show that the very severe soil erosion class is characterized by PSI velocity with higher negative values, followed by the successively lower classes. Results strongly suggest that RUSLE output can be improved as well as validated using a velocity map derived from radar data

Correlated MR spectroscopic imaging of breast cancer to investigate metabolites and lipids: acceleration and compressed sensing reconstruction

ObjectivesThe main objective of this work was to detect novel biomarkers in breast cancer by spreading the MR spectra over two dimensions in multiple spatial locations using an accelerated 5D EP-COSI technology.MethodsThe 5D EP-COSI data were non-uniformly undersampled with an acceleration factor of 8 and reconstructed using group sparsity-based compressed sensing reconstruction. Different metabolite and lipid ratios were then quantified and statistically analyzed for significance. Linear discriminant models based on the quantified metabolite and lipid ratios were generated. Spectroscopic images of the quantified metabolite and lipid ratios were also reconstructed.ResultsThe 2D COSY spectra generated using the 5D EP-COSI technique showed differences among healthy, benign, and malignant tissues in terms of their mean values of metabolite and lipid ratios, especially the ratios of potential novel biomarkers based on unsaturated fatty acids, myo-inositol, and glycine. It is further shown the potential of choline and unsaturated lipid ratio maps, generated from the quantified COSY signals across multiple locations in the breast, to serve as complementary markers of malignancy that can be added to the multiparametric MR protocol. Discriminant models using metabolite and lipid ratios were found to be statistically significant for classifying benign and malignant tumor from healthy tissues.ConclusionsAccelerated 5D EP-COSI technique demonstrates the potential to detect novel biomarkers such as glycine, myo-inositol, and unsaturated fatty acids in addition to commonly reported choline in breast cancer, and facilitates metabolite and lipid ratio maps which have the potential to play a significant role in breast cancer detection.Advances in knowledgeThis study presents the first evaluation of a multidimensional MR spectroscopic imaging technique for the detection of potentially novel biomarkers based on glycine, myo-inositol, and unsaturated fatty acids, in addition to commonly reported choline. Spatial mapping of choline and unsaturated fatty acid ratios with respect to water in malignant and benign breast masses are also shown. These metabolic characteristics may serve as additional biomarkers for improving the diagnostic and therapeutic evaluation of breast cancer

Ensemble Learning for Breast Cancer Lesion Classification: A Pilot Validation Using Correlated Spectroscopic Imaging and Diffusion-Weighted Imaging.

The main objective of this work was to evaluate the application of individual and ensemble machine learning models to classify malignant and benign breast masses using features from two-dimensional (2D) correlated spectroscopy spectra extracted from five-dimensional echo-planar correlated spectroscopic imaging (5D EP-COSI) and diffusion-weighted imaging (DWI). Twenty-four different metabolite and lipid ratios with respect to diagonal fat peaks (1.4 ppm, 5.4 ppm) from 2D spectra, and water and fat peaks (4.7 ppm, 1.4 ppm) from one-dimensional non-water-suppressed (NWS) spectra were used as the features. Additionally, water fraction, fat fraction and water-to-fat ratios from NWS spectra and apparent diffusion coefficients (ADC) from DWI were included. The nine most important features were identified using recursive feature elimination, sequential forward selection and correlation analysis. XGBoost (AUC: 93.0%, Accuracy: 85.7%, F1-score: 88.9%, Precision: 88.2%, Sensitivity: 90.4%, Specificity: 84.6%) and GradientBoost (AUC: 94.3%, Accuracy: 89.3%, F1-score: 90.7%, Precision: 87.9%, Sensitivity: 94.2%, Specificity: 83.4%) were the best-performing models. Conventional biomarkers like choline, myo-Inositol, and glycine were statistically significant predictors. Key features contributing to the classification were ADC, 2D diagonal peaks at 0.9 ppm, 2.1 ppm, 3.5 ppm, and 5.4 ppm, cross peaks between 1.4 and 0.9 ppm, 4.3 and 4.1 ppm, 2.3 and 1.6 ppm, and the triglyceryl-fat cross peak. The results highlight the contribution of the 2D spectral peaks to the model, and they demonstrate the potential of 5D EP-COSI for early breast cancer detection

Dictionary learning compressed sensing reconstruction: pilot validation of accelerated echo planar J-resolved spectroscopic imaging in prostate cancer.

ObjectivesThis study aimed at developing dictionary learning (DL) based compressed sensing (CS) reconstruction for randomly undersampled five-dimensional (5D) MR Spectroscopic Imaging (3D spatial + 2D spectral) data acquired in prostate cancer patients and healthy controls, and test its feasibility at 8x and 12x undersampling factors.Materials and methodsProspectively undersampled 5D echo-planar J-resolved spectroscopic imaging (EP-JRESI) data were acquired in nine prostate cancer (PCa) patients and three healthy males. The 5D EP-JRESI data were reconstructed using DL and compared with gradient sparsity-based Total Variation (TV) and Perona-Malik (PM) methods. A hybrid reconstruction technique, Dictionary Learning-Total Variation (DLTV), was also designed to further improve the quality of reconstructed spectra.ResultsThe CS reconstruction of prospectively undersampled (8x and 12x) 5D EP-JRESI data acquired in prostate cancer and healthy subjects were performed using DL, DLTV, TV and PM. It is evident that the hybrid DLTV method can unambiguously resolve 2D J-resolved peaks including myo-inositol, citrate, creatine, spermine and choline.ConclusionImproved reconstruction of the accelerated 5D EP-JRESI data was observed using the hybrid DLTV. Accelerated acquisition of in vivo 5D data with as low as 8.33% samples (12x) corresponds to a total scan time of 14 min as opposed to a fully sampled scan that needs a total duration of 2.4 h (TR = 1.2 s, 32 [Formula: see text]×16 [Formula: see text]×8 [Formula: see text], 512 [Formula: see text] and 64 [Formula: see text])

Design of SCALES: a 2-5 micron coronagraphic integral field spectrograph for Keck Observatory

editorial reviewedWe present the design of SCALES (Slicer Combined with Array of Lenslets for Exoplanet Spectroscopy) a new 2-5 micron coronagraphic integral field spectrograph under construction for Keck Observatory. SCALES enables low-resolution (R∼50) spectroscopy, as well as medium-resolution (R∼4,000) spectroscopy with the goal of discovering and characterizing cold exoplanets that are brightest in the thermal infrared. Additionally, SCALES has a 12x12" field-of-view imager that will be used for general adaptive optics science at Keck. We present SCALES's specifications, its science case, its overall design, and simulations of its expected performance. Additionally, we present progress on procuring, fabricating and testing long lead-time components