The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies

The prediction of the public health impact of a preventive strategy provides valuable support for decision-making. International guidelines for hypertension management have introduced the level of absolute cardiovascular risk in the definition of the treatment target population. The public health impact of implementing such a recommendation has not been measured.We assessed the efficiency of three treatment scenarios according to historical and current versions of practice guidelines on a Realistic Virtual Population representative of the French population aged from 35 to 64 years: 1) BP≥160/95 mm Hg; 2) BP≥140/90 mm Hg and 3) BP≥140/90 mm Hg plus increased CVD risk. We compared the eligibility following the ESC guidelines with the recently observed proportion of treated amongst hypertensive individuals reported by the Etude Nationale Nutrition Santé survey. Lowering the threshold to define hypertension multiplied by 2.5 the number of eligible individuals. Applying the cardiovascular risk rule reduced this number significantly: less than 1/4 of hypertensive women under 55 years and less than 1/3 of hypertensive men below 45 years of age. This was the most efficient strategy. Compared to the simulated guidelines application, men of all ages were undertreated (between 32 and 60%), as were women over 55 years (70%). By contrast, younger women were over-treated (over 200%).The global CVD risk approach to decide for treatment is more efficient than the simple blood pressure level. However, lack of screening rather than guideline application seems to explain the low prescription rates among hypertensive individuals in France. Multidimensional analyses required to obtain these results are possible only through databases at the individual level: realistic virtual populations should become the gold standard for assessing the impact of public health policies at the national level

La rigidification : une stratégie efficace d'accès à des polymères et oligomères conjugués à faible bande interdite

Une nouvelle stratégie d'accès à des semi-conducteurs organiques à faible bande interdite est développée. L'application de cette nouvelle approche basée sur la rigidification du système conjugué à différentes classes de polymères et d'oligomères conjugués dérivés du thiophène conduit à une réduction considérable de la largeur de la bande interdite qui atteint des valeurs parmi les plus faibles connues jusqu'à présent

Polymères conjugués à faible bande interdite dérivés de bithiophènes rigidifiés

De nouveaux polymères conducteurs à faible bande interdite ont été synthétisés par électropolymérisation de bithiophènes rigidifiés par pontage des cycles thiophéniques

Chiral a-Aminoorganostannanes : Precursors of a-Aminoorganolithiums

Communication par affiche intitulée (présentée par V. Coeffard) : Chiral a-Aminoorganostannanes : Precursors of a-Aminoorganolithium

Foreign direct investment in the Ottoman Empire: Attitudes and political risk

This study examines political risk for foreign direct investment in the Ottoman Empire during the late nineteenth and early twentieth centuries. Such a study has not previously been carried out. Despite many vicissitudes, such as wars and rebellions, the investment climate was more welcoming as compared to neighbouring lands such as Russia and the Balkan countries. While the Ottomans had a corrupt bureaucracy, as in Russia and the Balkans, they were free of xenophobia. Even those Ottoman intellectuals who were against complete freedom in international trade acknowledged the necessity of attracting foreign capital to the country, and suggested policy recommendations.Ottoman Empire, foreign direct investment, political risk, host country attitude, European Powers,

CCDC 764884: Experimental Crystal Structure Determination

Related Article: A.Tabatchnik-Rebillon, C.Aube, H.Bakkali, T.Delaunay, G.T.Manh, V.Blot, C.Thobie-Gautier, E.Renault, M.Soulard, A.Planchat, J.-Y.Le Questel, R.Le Guevel, C.Guguen-Guillouzo, B.Kauffmann, Y.Ferrand, I.Huc, K.Urgin, S.Condon, E.Leonel, M.Evain, J.Lebreton, D.Jacquemin, M.Pipelier, D.Dubreuil|2010|Chem.-Eur.J.|16|11876|doi:10.1002/chem.201000859,Related Article: A.Tabatchnik, V.Blot, M.Pipelier, D.Dubreuil, E.Renault, J.-Y.Le Questel|2010|J.Phys.Chem.A|114|6413|doi:10.1021/jp101394t,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.