1 research outputs found
Chemical Constituents of <i>Mangifera indica</i> and Their Antiausterity Activity against the PANC‑1 Human Pancreatic Cancer Cell Line
Human pancreatic cancer cell lines
such as PANC-1 have an altered
metabolism, enabiling them to tolerate and survive under extreme conditions
of nutrient starvation. The search for candidates that inhibit their
viability during nutrition starvation represents a novel antiausterity
strategy in anticancer drug discovery. A methanol extract of the bark
of <i>Mangifera indica</i> was found to inhibit the survival
of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived
conditions with a PC<sub>50</sub> value of 15.5 μg/mL, without
apparent toxicity, in normal nutrient-rich conditions. Chemical investigation
on this bioactive extract led to the isolation of 19 compounds (<b>1</b>–<b>19</b>), including two new cycloartane-type
triterpenes, mangiferolate A (<b>1</b>) and mangiferolate B
(<b>2</b>). The structures of <b>1</b> and <b>2</b> were determined by NMR spectroscopic analysis. Among the isolated
compounds, mangiferolate B (<b>2</b>) and isoambolic acid (<b>12</b>) exhibited potent preferential cytotoxicity against PANC-1
human pancreatic cancer cells under the nutrition-deprived condition
with PC<sub>50</sub> values of 11.0 and 4.8 μM, respectively