Paleocene-Eocene Land Mammals From Three New Latest Clarkforkian And Earliest Wasatchian Wash Sites At Polecat Bench In the Northern Bighorn Basin, Wyoming

http://deepblue.lib.umich.edu/bitstream/2027.42/49356/1/Vol 31 No11 final 12-11-06.pd

Comparing monthly statistical distributions of wind speed measured at wind towers and estimated from ERA-Interim

International audienceThe energy sector is undergoing a major transformation with an increasing share of power supply from variable renewable energy sources and an increasing variability in energy demand in a variable and changing climate. The European Climatic Energy Mixes (ECEM) project will develop a demonstrator to assess how well different energy supply mixes in Europe will meet demand, over seasonal to long-term decadal time horizons, focusing on the role climate has on the mixes. ECEM is funded under the Copernicus Climate Change Service, operated by ECMWF on behalf of the European Union. Many surface climate variables needed to develop energy profiles are provided by the ERA-Interim Reanalysis. Among these profiles, are wind power supply with wind speed at different heights as main inputs to determine periods when the wind power plants are expected to produce more or less than expected. In this view, a preliminary assessment of the monthly statistical distribution of wind speed at the standard height for wind power plants (80 m) has been performed. Time series of wind speed were obtained for the towers at Cabauw in The Netherlands and offshore at Docking Shoal in the North Sea. Reference statistical distributions were built for each month. Similarly, estimated statistical distributions were built using ERA-Interim estimates of wind speed at different levels. One series was built with a power approach and a second with a log approach. The estimated statistical distributions are then compared to the reference for each month. The log approach produces stronger winds than the power approach for both sites. At Cabauw, both approaches do not produce enough large wind speed for all months. At Docking Shoal, the power approach exhibits statistical distributions very close to the reference ones. Those from the log approach are biased towards higher wind speeds

On the linguistic linked open data infrastructure

In this paper we describe the current state of development of the Linguistic Linked Open Data (LLOD) infrastructure, an LOD(sub-)cloud of linguistic resources, which covers various linguistic data bases, lexicons, corpora, terminology and metadata repositories.We give in some details an overview of the contributions made by the European H2020 projects “Prêt-à-LLOD” (‘Ready-to-useMultilingual Linked Language Data for Knowledge Services across Sectors’) and “ELEXIS” (‘European Lexicographic Infrastructure’) to the further development of the LLOD

Improvement of European translational cancer research. Collaboration between comprehensive cancer centers

Even though the increasing incidence of cancer is mainly a consequence of a population with a longer life span, part of this augmentation is related to the increasing prevalence of patients living with a chronic cancer disease. To fight the problem, improved preventive strategies are mandatory in combination with an innovative health care provision that is driven by research. To overcome the weakness of translational research the OECI is proposing a practical approach as part of a strategy foreseen by the EUROCAN+PLUS feasibility study, which was launched by the EC in order to identify mechanisms for the coordination of cancer research in Europe

Candida Arteritis in Patients Who Have Not Received Organ Transplants: Case Report and Review of the Literature

Fungal arteritis is a rare entity, associated with significant morbidity and mortality, that typically involves graft arteries in solid organ transplant recipients. Here, we report the first case of Candida carotid arteritis and review 22 other cases of Candida arteritis reported since 1966 in patients who have not received transplants. Most patients had serious underlying conditions. All cases were anatomically characterized by pseudoaneurysm formation. Patients presented with fever (n=17), local pain (n=13), and an expanding pulsatile mass (n=4), with subsequent rupture and hemorrhage (n=7). Evidence of Candida colonization or infection was present in 15 patients before arteritis occurred. Treatment typically included a combined surgical and antifungal approach. The outcome was favorable in 11 patients, but follow-up was limited. A high index of suspicion, early diagnosis, and prompt antifungal and surgical treatment seem crucial to efforts to avoid life-threatening arterial rupture and hemorrhag

Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most common cause of anovulation in women. Previous studies suggest that the pathogenesis of PCOS may involve interrelated abnormalities of the insulin-like growth factor (IGF) and ovarian steroidogenesis systems. We investigated this hypothesis in fasting serum samples from 140 women with PCOS (age, 27.4 +/- 0.4 yr; body mass index, 26.3 +/- 0.5 kg/m2; mean +/- SEM). IGF-related parameters were also studied in a group of normoovulatory women (n = 26; age, 26 +/- 4 yr; body mass index, 23.6 +/- 4.3 kg/m2). For the PCOS group, the mean testosterone (T) level was 2.5 +/- 0.1 nmol/L, and it was significantly correlated with LH (r = 0.41; P < 10(-6)), estrone (r = 0.33; P = 0.016), estradiol (r = 0.18; P = 0.04), and androstenedione (AD; P < 10(-6)), but not with dehydroepiandrosterone sulfate (P = 0.71), a marker of adrenal steroidogenesis. T and AD were also related to total ovarian follicle number and ovarian size, as previously found with normoovulatory women (1). There were no differences between the PCOS subjects and the normoovulatory group for total IGF-I, IGF-II, or IGF-binding protein-3 (IGFBP-3). However, IGFBP-1 levels were significantly decreased in the PCOS group (1.0 +/- 0.2 vs. 7.3 +/- 1.1 ng/mL; P < 0.001) and were inversely correlated with serum insulin levels (r = -0.50; P < 10(-8)). Serum levels of free IGF-I (fIGF-I) were elevated (5.9 +/- 0.3 vs. 2.7 +/- 0.3 ng/mL; P < 0.001) in inverse relation with IGFBP-1 (r = -0.31; P = 0.046). Serum fIGF-I levels were related to total follicle number (r = - 0.35; P < 10(-4)) and to the ratio of sex hormone-binding globulin to T (r = -0.23; P = 0.009). However, these relationships were not independent of other variables. Despite the more than 2-fold elevation in fIGF-I levels, significant relationships between fIGF-I and markers of ovarian steroidogenesis (T, AD, estradiol, and estrone) could not be demonstrated. In conclusion, although we confirmed correlations between LH and hyperandrogenemia and have found abnormalities in the IGF system in a large cohort of PCOS subjects, a direct relationship between hyperandrogenism and the IGF system could not be shown. Previous studies suggest that elevated LH and hyperinsulinemia lead to excess ovarian androgen synthesis in PCOS and that the intraovarian IGF system is important for normal follicle development and may be important in the arrested state of follicle development in PCOS. However, the data presented in this cross-sectional study suggest that insulin-related changes in circulating IGFBP-1 and subsequent elevation of fIGF-I reflect insulin resistance and have little enhancing effects on ovarian steroidogenesis in this disorder