Kinetic parameters of HDL apolipoprotein AI and HDL-cholesteryl ester before (week 0) and after 4 weeks of NA treatment (week 4) identified using models of Fig 1.

<p>FCR, fractional catabolic rate; APR, absolute production rate; HDL-UC, HDL unesterified cholesterol concentration; HDL-CE, HDL cholesteryl ester concentration; K_LCAT, cholesterol esterification rate by LCAT. Data are expressed as median [minimum-maximum], n = 6.</p

Monocompartmental model used for the modeling of apolipoprotein AI (apoAI) (A) and HDL cholesteryl ester (B) turnover in dogs.

<p>UC, unesterified cholesterol; CE, cholesteryl ester; k₀₁, apoAI uptake; k_01’, CE selective uptake; k_LCAT, cholesterol esterification rate.</p

Relative expression of PPARα, SR-BI, ABCA1 and ATP synthase mRNA in liver of NA treated dogs, before (week 0) and after the end of the 4 weeks treatment (week 4).

<p>(PPARα: peroxisome proliferator-activated receptor α, ABCA1: ATP binding cassette A1, SR-BI: scavenger receptor class B type I), n = 6.</p