Mean ± SEM of mRNA abundance (CT, log₂) of genes encoding cytokines and enzymes in blood of diseased dogs one day before or at the day of death compared to diseased dogs that survived corresponding in time.

<p>Mean ± SEM of mRNA abundance (CT, log₂) of genes encoding cytokines and enzymes in blood of diseased dogs one day before or at the day of death compared to diseased dogs that survived corresponding in time.</p

Mean ± SEM area under the curve of relative mRNA expression (CT, log₂) of genes encoding cytokines and enzymes in whole blood of diseased dogs during the first three days after admission to the clinic (non-survivors excluded).

<p>Mean ± SEM area under the curve of relative mRNA expression (CT, log₂) of genes encoding cytokines and enzymes in whole blood of diseased dogs during the first three days after admission to the clinic (non-survivors excluded).</p

Time course of IL-10, TNF-α and 5-LO expression (mean ± SEM) in 24 survivor dogs with acute leptospirosis, including 13 dogs with (group LAPH) and 11 dogs without LAPH (group nLAPH).

<p>Differences between the disease groups LAPH and nLAPH are indicated as <b>+</b> (<i>P</i> < 0.1) and * (<i>P</i> < 0.05). Different letters indicate significant differences between the days (a,b,c for the LAPH group; A,B,C for the nLAPH group). Statistical significance. IL-10: disease effect <i>P</i> = 0.02, time effect <i>P</i><0.01, and interaction <i>P</i> = 0.42; TNF-α: disease effect <i>P</i> = 0.35, time effect <i>P</i><0.01, and interaction <i>P</i> = 0.94; 5-LO: disease effect <i>P</i> = 0.01, time effect <i>P</i> = 0.09, and interaction <i>P</i> = 0.98.</p

Mean ± SEM of clinical characteristics of all dogs on the day of or one day after admission to the clinic.

<p>Mean ± SEM of clinical characteristics of all dogs on the day of or one day after admission to the clinic.</p

Detailed primers and conditions used for real-time PCR assays.

<p>Detailed primers and conditions used for real-time PCR assays.</p