11 research outputs found
The use of neurovascular ultrasound versus digital subtraction angiography in acute ischemic stroke
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
PrevalĂŞncia da sĂndrome de burnout em trabalhadores de enfermagem de um hospital de grande porte da RegiĂŁo Sul do Brasil
Fatores médicos e não-médicos associados às taxas de cesariana em um hospital universitário no Sul do Brasil
Exacerbations of COPD and symptoms of gastroesophageal reflux: a systematic review and meta-analysis
Risk of Hemorrhage during Needle-Based Ophthalmic Regional Anesthesia in Patients Taking Antithrombotics: A Systematic Review.
BACKGROUND:Patients undergoing ophthalmic surgery are usually elderly and, due to systemic disease, may be on long-term therapy, such as antithrombotic agents. Rates of hemorrhagic complications associated with invasive procedures may be increased by the use of anticoagulants and antiplatelet agents. OBJECTIVE:To compare the incidence of hemorrhagic complications in patients undergoing needle-based ophthalmic regional anesthesia between patients on antithrombotic therapy and those not on such therapy. METHODS:A systematic review was conducted by two independent reviewers based on searches of Cochrane, LILACS, PubMed, Scopus, Web of Science, and the "gray" literature (Google Scholar). The end search date was May 8, 2015, across all databases. RESULTS:Five studies met the eligibility criteria. In three studies, individual risk of bias was low, and in two of them, moderate. In all studies, no differences regarding mild to moderate incidence of hemorrhagic complications were found between patients using antithrombotics (aspirin, clopidogrel, and warfarin) and those not using them. Rates of severe hemorrhagic complication were very low (0.04%) in both groups, supporting the safety of needle blocks, even in patients using antithrombotics. High heterogeneity across studies prevented meta-analysis. Limitations to these results include low statistical power in three experimental studies and a large 95% confidence interval in the two retrospective cohorts. CONCLUSION:In this review, none of the selected studies showed significant bleeding related to needle-based ophthalmic regional anesthesia in association with the use of aspirin, clopidogrel, or vitamin K inhibitors. Since the available data is not powerful enough to provide a reliable evaluation of the true effect of antithrombotics in this setting, new studies to address these limitations are necessary
Biochemical and histopathological parameters analyzed in rabbits fed a diet enriched with fat/sucrose/cholesterol and treated with vitamin D
Flow diagram of literature search and selection criteria.
<p>Flow diagram of literature search and selection criteria.</p