INFLUENCE OF AGING ON THE DYNAMICS OF LATERAL STABILIZATION IN WALKING, IN DIFFERENT EXPERIHENTAL CONDITIONS RELATED TO SHOE WEARING AND FLOOR HARDNESS

Review of biomechanics literature on the influence of aging on the locomotor system indicates that safe load bearing as well as deformation sustaining capabilities of biological tissues decrease with age. Postural studies of older populations have di8closed more body sway than in younger age groups and have often associated loss of balance with locomotion problems of old age people. On the other hand, biomechanical studies of walking and running have already demonstrated t h a t wearing shoes and shoe characteristics can play an important r o l e in shock absorption. However the influence of aging on the dynamic of lateral stabilization in walking in relationship with shoe wearing and floor hardness has received very little attention. Such a biomechanical approach t o locomotion is becoming more important since more and more older people are involved in sport and fitness activities including some form of locomotion. The present study has been undertaken in order to investigate the influence of aging together with shoe wearing and floor hardness on some of the main components, of lateral stabilization in walking, namely the lateral forces, the lateral impulse and the lateral deviation o f the center of pressure. Three groups of 15 physically active male subjects (17-22, 40-45 and 65-70 years old) were instructed to walk on a tri-dimensional force platform a t a predetermined pace set with a metronome;. Experimental conditions included walking barefoot and with regular shoes, on a hard and a softer surfaces. Kinetic data were recorded on the 5th, 25th, 50th, 100th and 500th steps for each condition, with the use of the computerized . Ariel Performance Analysis System. Analysis of the results disclosed important differences between the age groups in all three experimental parameters. Lower lateral forces exerted by the older age group lead t o the hypothesis of a different stabilization strategy based on energy saving. Findings were also discussed in relationship with the lateral stabilization process and applications were made to sport and fitness activities a s well a s the daily living situations

A BIOMECHANICAL AND KINESIOLOGICAL APPROACH IN THE TEACHING OF EFFICIENT SURGICAL SKILLS TO MEDICAL STUDENTS

A competency-based surgery residents teaching and training program including a biomechanical and kinesiological approach was developed in order to improve procedural learning and mastery of invasive skills. Principles of biomechanics and kinesiology have been taught and applied to many aspects of surgical tasks, including instrument holding and manipulation, body positioning and posture, segments alignment. Results demonstrate more precise movements and more efficient performance of surgical tasks in residents participating in the program

Hair on near-extremal Reissner-Nordstrom AdS black holes

We discuss hairy black hole solutions with scalar hair of scaling dimension $\Delta$ and (small) electromagnetic coupling $q^2$, near extremality. Using trial functions, we show that hair forms below a critical temperature $T_c$ in the region of parameter space $(\Delta, q^2)$ above a critical line $q_c^2 (\Delta)$. For $\Delta > \Delta_0$, the critical coupling $q_c^2$ is determined by the AdS$_2$ geometry of the horizon. For $\Delta < \Delta_0$, $q_c^2$ is {\em below} the value suggested by the near horizon geometry at extremality. We provide an analytic estimate of $\Delta_0$ (numerically, $\Delta_0 \approx 0.64$). We also compute analytically the true critical line for the entire range of the scaling dimension. In particular for $q=0$, we obtain an instability down to the unitarity bound. We perform explicit analytic calculations of $T_c$, the condensate and the conductivity. We show that the energy gap in units of $T_c$ diverges as we approach the critical line ($T_c \to 0$).Comment: PRD version: 15 pages, 9 figures, corrected typos, improved discussio

Simulating Fully‐Integrated Hydrological Dynamics in Complex Alpine Headwaters: Potential and Challenges

Highly simplified approaches continue to underpin hydrological climate change impact assessments across the Earth's mountainous regions. Fully-integrated surface-subsurface models may hold far greater potential to represent the distinctive regimes of steep, geologically-complex headwater catchments. However, their utility has not yet been tested across a wide range of mountainous settings. Here, an integrated model of two adjacent calcareous Alpine headwaters that accounts for two-dimensional surface flow, three-dimensional (3D) variably-saturated groundwater flow, and evapotranspiration is presented. An energy balance-based representation of snow dynamics contributed to the model's high-resolution forcing data, and a sophisticated 3D geological model helped to define and parameterize its subsurface structure. In the first known attempt to calibrate a catchment-scale integrated model of a mountainous region automatically, numerous uncertain model parameters were estimated. The salient features of the hydrological regime could ultimately be satisfactorily reproduced – over an 11-month evaluation period, the Nash-Sutcliffe efficiency of simulated streamflow at the main gauging station was 0.76. Spatio-temporal visualization of the forcing data and simulated responses further confirmed the model's broad coherence. Presumably due to unresolved local subsurface heterogeneity, closely replicating the somewhat contrasting groundwater level signals observed near to one another proved more elusive. Finally, we assessed the impacts of various simplifications and assumptions that are commonly employed in physically-based modeling – including the use of spatially uniform forcings, a vertically limited model domain, and global geological data products – on key simulated outputs, finding strongly affected model performance in many cases. Although certain outstanding challenges must be overcome if the uptake of integrated models in mountain regions around the world is to increase, our work demonstrates the feasibility and benefits of their application in such complex systems

Communicative Competence for Researchers working with LGBTQ Communities

The ethical principles of respect and justice oblige the use of culturally sensitive approaches when engaging participants in research, however cultural competence training is lacking for researchers who work with LGBTQ populations. The purpose of this study was to explore how researchers can create a welcoming research environment for LGBTQ research participants in the context of historical distrust of medical research as a barrier to research participation among minority populations. Grounded by a framework of communicative competence, this study explored elements of preferred communication during recruitment and informed consent for research involving LGBTQ participants. Grammatical, sociolinguistic, strategic and discourse competence domains aided exploration of the preferences held by participants in LGBTQ sub-groups, as well as the perceived barriers to research. Thirty-six participants, who self-identified as part of the LGBTQ community and were recruited through our community partner, the Center for Health Impact, took part in either focus groups or individual interviews. Preliminary analysis reveals community engagement and building trust are key, particularly in an academic medical center where a patient\u27s clinical experiences may impact their willingness to become a research participant. Participants offered insight into each competence domain, covering: terminology to promote inclusivity, body language to avoid, reducing stigma by being up front and feedback on crafting a more LGBTQ-friendly basic demography questionnaire. These findings will aid in the refinement of an LGBTQ-focused version of our Simulation-based Community-engaged Research Intervention for Informed Consent Protocol Testing and Training (SCRIIPTT) to build communicative competence among clinical researchers

Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer

Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which is potentially correlated with chemotherapy response. Here, we aimed to further elucidate the KSR1-regulated signalling in response to genotoxic agents in breast cancer. Stable isotope labelling by amino acids in cell culture (SILAC) coupled to high-resolution mass spectrometry (MS) was implemented to globally characterise cellular protein levels induced by KSR1 in the presence of doxorubicin or etoposide. The acquired proteomic signature was compared and GO-STRING analysis was subsequently performed to illustrate the activated functional signalling networks. Furthermore, the clinical associations of KSR1 with identified targets and their relevance in chemotherapy response were examined in breast cancer patients. We reveal a comprehensive repertoire of thousands of proteins identified in each dataset and compare the unique proteomic profiles as well as functional connections modulated by KSR1 after doxorubicin (Doxo-KSR1) or etoposide (Etop-KSR1) stimulus. From the up-regulated top hits, several proteins, including STAT1, ISG15 and TAP1 are also found to be positively associated with KSR1 expression in patient samples. Moreover, high KSR1 expression, as well as high abundance of these proteins, is correlated with better survival in breast cancer patients who underwent chemotherapy. In aggregate, our data exemplify a broad functional network conferred by KSR1 with genotoxic agents and highlight its implication in predicting chemotherapy response in breast cancer

Controlling Hydrogen Activation, Spillover, and Desorption with Pd-Au Single-Atom Alloys

Key descriptors in hydrogenation catalysis are the nature of the active sites for H2 activation and the adsorption strength of H atoms to the surface. Using atomically resolved model systems of dilute Pd-Au surface alloys and density functional theory calculations, we determine key aspects of H2 activation, diffusion, and desorption. Pd monomers in a Au(111) surface catalyze the dissociative adsorption of H2 at temperatures as low as 85 K, a process previously expected to require contiguous Pd sites. H atoms preside at the Pd sites and desorb at temperatures significantly lower than those from pure Pd (175 versus 310 K). This facile H2 activation and weak adsorption of H atom intermediates are key requirements for active and selective hydrogenations. We also demonstrate weak adsorption of CO, a common catalyst poison, which is sufficient to force H atoms to spill over from Pd to Au sites, as evidenced by low-temperature H2 desorption

In-air hearing of a diving duck: A comparison of psychoacoustic and auditory brainstem response thresholds

Auditory sensitivity was measured in a species of diving duck that is not often kept in captivity, the lesser scaup. Behavioral (psychoacoustics) and electrophysiological [the auditory brainstem response (ABR)] methods were used to measure in-air auditory sensitivity, and the resulting audiograms were compared. Both approaches yielded audiograms with similar U-shapes and regions of greatest sensitivity (2000-3000 Hz). However, ABR thresholds were higher than psychoacoustic thresholds at all frequencies. This difference was least at the highest frequency tested using both methods (5700 Hz) and greatest at 1000 Hz, where the ABR threshold was 26.8 dB higher than the behavioral measure of threshold. This difference is commonly reported in studies involving many different species. These results highlight the usefulness of each method, depending on the testing conditions and availability of the animals