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    Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F‑Actin

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    The total synthesis of (−)-amphidinolide K (<b>1</b>) based on asymmetric addition of allylsilane <b>C1</b>–<b>C8</b> to enal <b>C9</b>–<b>C22</b> is reported. The 1,9,18-tris-<i>O</i>-TBDPS ether was converted into the desired 9,18-dihydroxy acid. Its macrolactonization was accomplished by the Shiina method. Compound <b>1</b> together with some of its stereoisomers and analogues were subjected to evaluation of the possible disruption of the α,ÎČ-tubulin–microtubule and/or G-actin–F-actin equilibria. Compound <b>1</b> behaves as a stabilizer of actin filaments (F-actin) in vitro
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