1 research outputs found
Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes FâActin
The total synthesis of (â)-amphidinolide
K (<b>1</b>) based on asymmetric addition of allylsilane <b>C1</b>â<b>C8</b> to enal <b>C9</b>â<b>C22</b> is reported.
The 1,9,18-tris-<i>O</i>-TBDPS ether was converted into
the desired 9,18-dihydroxy acid. Its macrolactonization was accomplished
by the Shiina method. Compound <b>1</b> together with some of
its stereoisomers and analogues were subjected to evaluation of the
possible disruption of the α,ÎČ-tubulinâmicrotubule
and/or G-actinâF-actin equilibria. Compound <b>1</b> behaves
as a stabilizer of actin filaments (F-actin) in vitro