Fetomaternal outcome of women with thrombocytopenia in labour

Background: This study was conducted to study fetomaternal outcome in pregnancy with severity of thrombocytopenia. Methods: It was a prospective observational study of fetomaternal outcome of women with thrombocytopenia admitted in labour room of a tertiary health care center of south Gujarat for 1-year period (April 2021-March 2022) after official approval from ethical committee. 100 consecutive consenting women with thrombocytopenia admitted in labour room of New Civil Hospital Surat were enrolled in this study. Results: Mild thrombocytopenia was noted in 68% of the total cases, moderate thrombocytopenia in 27% and severe thrombocytopenia in 5% of cases. 59 subjects belong to age group of 20-25 years, 56 subjects were multipara, 70 subjects were registered antenatally, 68 subjects were delivered beyond 37 weeks of gestation. 48 subjects underwent LSCS and rest were delivered vaginally. 29 subjects had maternal complication. 95 subjects delivered alive baby of which 14 had NICU admission and 5 subjects had preterm still birth baby. Conclusions: Thrombocytopenia is the second most common haematological finding in pregnancy next to anaemia. Majority of cases generally present at gestational age beyond thirty-seven weeks and belong to category of mild thrombocytopenia. Efforts should be made on improving antenatal registration, screening of maternal thrombocytopenia, early diagnosis and treatment

NON-DESTRUCTIVE RAMAN SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST FROM TABLET DOSAGES FORM

Objective: A rapid, non-destructive and non-solvent raman spectroscopic method for estimation of Montelukast from tablet dosages form Methods: Quantification was carried out by measuring the intensity of analyte peak at 1440 cm-1. Each Raman spectrum corresponded to an accumulation of 4 scans with an exposure time of 5 sec for each scan with a total integration time of 20 sec.Results: The method exhibited linearity between 2 mg-24 mg show well resolve quantification From MON. The linearity equation was calculated as y = 13.036x+70.819 and the correlation coefficient was found to be 0.997 for MON. LOD (limit of detection) and LOQ(limit of quantification) values were calculated using the calibration curve slope and standard deviation of the response. The LOD (limit of detection) and LOQ (limit of quantification) values were found to be 1.71 mg and 5.13 mg respectively.Conclusion: The developed method was successfully applied for assay of montelukast in the intact formulation. The method was validated according to an international conference on harmonisation guidelines. A recent study, montelukast sodium had been analysed by the raman method, but, looking into the tremendous potential of raman spectroscopic method; it can be extended as a process analysis and technology tool in various quality checks during manufacturing of pharmaceutical products

Safety and Efficacy of Vacuum-Assisted Breast Biopsies under Ultrasound and Stereotactic Guidance

Purpose To evaluate the safety and efficacy of vacuum-assisted breast biopsy (VABB) under ultrasound and stereotactic guidance

Prognostic Value of Right Ventricular Systolic Pressure (RVSP) in Patients Hospitalized With Heart Failure

Background Pulmonary hypertension in patients with heart failure has been established as a poor prognosis marker. There is little evidence studying the association between right ventricular systolic pressure (RVSP) used as a surrogate for pulmonary pressure and outcomes in heart failure patients. Methods A total of 972 patients admitted with heart failure in a single center were included in the present study. All patients were stratified based on their RVSP as ≤40 mm Hg or \u3e40 mmHg. After comorbidities were matched using propensity scores, all-cause mortality, all-readmission, and cardiac readmission rates were analyzed between the two groups. Hazard ratio (HR) was used as an effect measure in our analysis. All analysis was carried out using STATA, version16.1. Results We included 345 heart failure patients in each group after propensity score matching. Hospitalizations with RVSP \u3e40 mm Hg were associated with higher rates of all-cause mortality compared with RVSP \u3c40 mm Hg [HR: 1.60; 95% CI: 1.22-2.09; P-value \u3c0.001]. Further, with all follow-up censored at 6 months RVSP \u3e40 mm Hg were associated with higher rates of all-cause readmission [HR: 1.37; 95% CI: 1.09-1.73; P value =0.008], and cardiac readmission [HR: 1.41; 95% CI: 1.07-1.85; P value =0.014] compared with RVSP \u3c40 mm Hg. Conclusion RVSP \u3e40 mmHg in heart failure patients was independently associated with higher rates of all-cause mortality, all-cause readmission, and cardiac readmission