Status of ψ\psi (3686), ψ\psi (4040), ψ\psi (4160), Y (4260), ψ\psi (4415) and X (4630) charmonia like states

We examine the status of charmonia like states by looking into the behaviour of the energy level differences and regularity in the behaviour of the leptonic decay widths of the excited charmonia states. The spectroscopic states are studied using a phenomenological Martin-like confinement potential and their radial wave functions are employed to compute the di-leptonic decay widths. Their deviations from the expected behaviour provide a clue to consider them as admixtures of the nearby S and D states. The present analysis strongly favour \\backslash$psi \$ (3686) as admixture of $c \bar{c}$ (2S) and $c \bar{c}$g (4.1 GeV) hybrid, \\backslash$psi \$ (4040) and \$$\backslash$psi \$ (4160) as admixture states of charmonia (3S, 3D) states with mixing angle \$$\backslash$theta \$ = 11$^\circ$and 45$^\circ$respectively. We identify Y (4260) as a pure$c \bar{c}$(4S) state whose leptonic decay is predicted as 0.65 keV. While X(4630) is closer to the$c \bar{c}$(6S) state. The status of \$$\backslash$psi \$ (4415) is still not clear as it does not fit to be pure or admixture state

2001 Bhuj-Kachchh earthquake: surface faulting and its relation with neotectonics and regional structures, Gujarat, Western India

Primary and secondary surface deformation related to the 2001 Bhuj-Kachchh earthquake suggests that thrusting movement took place along an E-W fault near the western extension of the South Wagad Fault, a synthetic fault of the Kachchh Mainland Fault (KMF). Despite early reconnaissance reports that concluded there was no primary surface faulting, we describe an 830 m long, 15-35 cm high, east-west-trending thrust fault scarp near where the seismogenic fault plane would project to the surface, near Bharodiya village (between 23°34.912'N, 70°23.942'E and 23°34.304'N, 70°24.884'E). Along most of the scarp Jurassic bedrock is thrust over Quaternary deposits, but the fault scarp also displaces Holocene alluvium and an earth dam, with dips of 13° to 36° south. Secondary co-seismic features, mainly liquefaction and lateral spreading, dominate the area south of the thrust. Transverse right-lateral movement along the «Manfara Fault» and a parallel fault near Bharodiya suggests segmentation of the E-W master faults. Primary (thrust) surface rupture had a length of 0.8 km, maximum displacement of about 35 cm, and average displacement of about 15 cm. Secondary (strike-slip) faulting was more extensive, with a total end-to-end length of 15 km, maximum displacement of 35 cm, and average displacement of about 20 cm

Clinical Pharmacology Studies in Critically Ill Children

Developmental and physiological changes in children contribute to variation in drug disposition with age. Additionally, critically ill children suffer from various life-threatening conditions that can lead to pathophysiological alterations that further affect pharmacokinetics (PK). Some factors that can alter PK in this patient population include variability in tissue distribution caused by protein binding changes and fluid shifts, altered drug elimination due to organ dysfunction, and use of medical interventions that can affect drug disposition (e.g., extracorporeal membrane oxygenation and continuous renal replacement therapy). Performing clinical studies in critically ill children is challenging because there is large inter-subject variability in the severity and time course of organ dysfunction; some critical illnesses are rare, which can affect subject enrollment; and critically ill children usually have multiple organ failure, necessitating careful selection of a study design. As a result, drug dosing in critically ill children is often based on extrapolations from adults or non-critically ill children. Dedicated clinical studies in critically ill children are urgently needed to identify optimal dosing of drugs in this population. This review will summarize the effect of critical illness on pediatric PK, the challenges associated with performing studies in this vulnerable subpopulation, and the clinical PK studies performed to date for commonly used drugs

Seismic Behaviour of Bridges Considering Soil-Structure Interaction

The soil-structure interaction has significant effect on seismic response of bridges in many situations. The choice of soil springs for response determination is an important consideration. This paper presents a comparative assessment of the seismic response of bridge substructure by four different types of frequency independent soil springs namely, Beredugo-Novak, Wolf, Bycroft-Parmelee and Terzaghi. The variation of equivalent weighted damping and equivalent seismic coefficient is also studied. The Terzaghi\u27s soil springs obtained by modulus of subgrade reaction approach are most flexible as compared to others. The responses are seen to be comparable with springs other than Terzaghi. The equivalent damping in higher modes is increased due to energy dissipation in soil. The codal provisions of equivalent seismic coefficient variation below scour level are generally unconservative

On the origin of the artesian groundwater and escaping gas at Narveri after the 2001 Bhuj earthquake

At Narveri, north of Khavada in the Great Rann of Kachchh, an outflow of groundwater continued even more than four months after the Bhuj earthquake of 26 January 2001, although at a considerably reduced rate compared to that immediately following the earthquake. Air or gas bubbling through the freshly oozing water has also been observed. We had collected a large number of samples from different parts of Gujarat, where post-earthquake groundwater outpourings were reported. Narveri, however, was the only site where the samples showed dissolved helium concentrations, significantly above the air equilibration value. Based on measurements of helium, radon, chloride, sulphate and sodium concentrations and temperature, we suggest that the flowing water and escaping gases at Narveri have a deep confined source with a reservoir age in excess of ~ 104 years

Medical research and ethics - Revisited

Ethics in the medical research is known since many years; however, there have been new developments in this area recently. A phenomenal improvement in the health-care system, leading to increased life expectancy, and thereby, newer lifestyle and other health-related diseases has opened avenues for newer drugs and health-care technology. However, these have to be tried and tested in the context of the disease epidemiology, health-care delivery and of course, medical ethics. Monitoring and evaluation of the treatment regimes of well documented effective medicines is also required. This is the core of medical research. With the ever increasing concept of evidence-based medical system, and thereby, a rapid rise in the number of clinical trials; the role of medical ethics is potentially increasing to keep the patient