170 research outputs found
EXPLORING LIPID-BASED DRUG DELIVERY IN CANCER THERAPY VIA LIPOSOMAL FORMULATIONS
In many countries across the world, cancer is a leading cause of death. Cancer is the biggest cause of death worldwide, with approximately 10 million fatalities expected in 2020, accounting for nearly one in every six deaths. Mutations in ~300 human genes can unleash cell division, potentially leading to cancer. The effectiveness of existing conventional therapies for a number of cancers is, however, inefficient in terms of safety and efficacy. Medication systems based on lipid can be configured to treat tumors passively with increasing safety by reducing toxicity and increasing efficacy by target drug delivery. Lipid-based drug dosage form is the new identified technological design to overcome problems such as water-soluble solubility and bioavailability. A wide range of product specifications determined by indication of disease, route of administration, price evaluation, safety, toxicity, and efficiency could be customized to lipid formulations. This analysis explores the current state of lipid drug delivery studies, including the production of cancer liposomes, different cancer-focused strategies, and liposomal formulation of numerous anti-cancer drugs
Orthopedic management of the extremities in patients with Morquio A syndrome.
BackgroundMusculoskeletal involvement in Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) contributes significantly to morbidity and mortality. While the spinal manifestations of the disorder have received considerable attention in the literature, there have been few reported studies to date to guide the management of the orthopedic problems associated with the lower and upper extremities.PurposeThe objective was to develop recommendations for the management of the extremities in patients with Morquio A syndrome.MethodsA group of specialists in orthopedics, pediatrics and genetics with experience in the management of Morquio A patients convened to review and discuss current clinical practices and to develop preliminary recommendations. Evidence from the literature was retrieved. Recommendations were further refined until consensus was reached.Results and conclusionsThis present article provides a detailed review and discussion of the lower and upper extremity deformities in Morquio A syndrome and presents recommendations for the assessment and treatment of these complications. Key issues, including the importance of early diagnosis and the implications of medical therapy, are also addressed. The recommendations herein represent an attempt to develop a uniform and practical approach to managing patients with Morquio A syndrome and improving their outcomes
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Advances in Multidetector CT Diagnosis of Pediatric Pulmonary Thromboembolism
Although pediatric pulmonary thromboembolism is historically believed to be rare with relatively little information available in the medical literature regarding its imaging evaluation, it is more common than previously thought. Thus, it is imperative for radiologists to be aware of the most recent advances in its imaging information, particularly multidetector computed tomography (MDCT), the imaging modality of choice in the pediatric population. The overarching goal of this article is to review the most recent updates on MDCT diagnosis of pediatric pulmonary thromboembolism
Strings on type IIB pp-wave backgrounds with interacting massive theories on the worldsheet
We consider superstring theories on pp-wave backgrounds which result in an
integrable supersymmetric Landau-Ginzburg theory on the
worldsheet. We obtain exact eigenvalues of the light-cone gauge superstring
hamiltonian in the massive and interacting world-sheet theory with
superpotential . We find the modes of the supergravity part of the
string spectrum, and their space-time interpretation. Because the system is
effectively at strong coupling on the worldsheet, these modes are not in
one-to-one correspondence with the usual type IIB supergravity modes in the
limit. However, the above correspondence holds in the limit.Comment: 20 pages, 1 figure; minor changes, comments adde
B and D Meson Decay Constants in Lattice QCD
We have calculated the decay constants of B and mesons with lattice QCD.
We use an improved action that takes light quark actions as a starting
point, tuned so that it can be directly applied at the physical masses of the
and quarks. Our results are f_B = 164 \err{+14}{-11} \pm 8 MeV,
f_{B_s} = 185 \err{+13}{-8} \pm 9 MeV, f_D = 194 \err{+14}{-10} \pm 10 MeV,
and f_{D_s} = 213 \err{+14}{-11} \pm 11 MeV in the quenched approximation.
The first error in each case is statistical, and the second is from
perturbation theory. We show that discretization errors are under control in
our approach, and smaller than our statistical errors. The effects of the
quenched approximation may raise our quenched result by up to 10%.Comment: 21 pages, 6 figure
Economic development, human development, and the pursuit of happiness, April 1, 2, and 3, 2004
This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This was the Center's spring conference, which took place during April 1, 2, and 3, 2004.The conference asks the questions, how can we make sure that the benefits of economic growth flow into health, education, welfare, and other aspects of human development; and what is the relationship between human development and economic development? Speakers and participants discuss the role that culture, legal and political institutions, the UN Developmental Goals, the level of decision-making, and ethics, play in development
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein
Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves of COVID19 infections despite an unprecedented mass vaccination necessitating continuous adaptation of therapeutics. Small animal models can facilitate understanding host-pathogen interactions, target selection for therapeutic drugs, and vaccine development, but availability and cost of studies in BSL3 facilities hinder progress. To generate a BSL2-compatibl
The Semileptonic Decays and from Lattice QCD
We present a lattice QCD calculation of the form factors and differential
decay rates for semileptonic decays of the heavy-light mesons and to
the final state . The results are obtained with three methodological
improvements over previous lattice calculations: a matching procedure that
reduces heavy-quark lattice artifacts, the first study of lattice-spacing
dependence, and the introduction of kinematic cuts to reduce model dependence.
We show that the main systematics are controllable (within the quenched
approximation) and outline how the calculations could be improved to aid
current experiments in the determination of~ and~.Comment: 35 pp, 12 fig
'Countries in the Air': Travel and Geomodernism in Louis MacNeice's BBC Features
In the middle stretch of his twenty-two-year BBC career, the poet and producer Louis MacNeice earned a reputation as one of the âundisputed masters of creative sound broadcastingâ, a reputation derived, in part, from a huge range of radio features that were founded upon his journeys abroad. Through close examination of some of his most significant overseas soundscapes â including Portrait of Rome (1947) and Portrait of Delhi (1948) â this article will consider the role and function of travel in shaping MacNeiceâs engagement with the radio feature as a modernist form at a particular transcultural moment when Britain moved through the end of the Second World War and the eventual disintegration of its empire
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