Genetic association between iron and ferritin levels and SNPs in <i>SLC11A2</i> and <i>TMPRSS6</i> in SAPHIR.

<p><u>Note</u>: For linear regression, an additive genetic effect of the SNPs on the outcome variable was assumed; linear regression analyses were adjusted for age and gender. The p-values were based on the log-transformed model, and the β-estimates were based on the model on the original scale.</p

SNP genotypes of the family within the two genes <i>SLC11A2</i> and <i>TMPRSS6</i>.

<p>SNP genotypes of the family within the two genes <i>SLC11A2</i> and <i>TMPRSS6</i>.</p

Genetic association between iron and ferritin levels and haplotype-pairs in <i>SLC11A2</i> and <i>TMPRSS6</i> in SAPHIR.

<p><u>Notes</u>: For the haplotype pairs in <i>SLC11A2</i> and <i>TMPRSS6</i>, the regression was performed on all haplotype pairs in one model with the most probable haplotype pair as the reference. For the combined analysis, each line reflects the results from a regression model of this particular haplotype-pair versus all other pairs on the traits (each model sex- and age-adjusted). The p-values are based on the log-transformed model; the β-estimates are based on the model on the original scale.</p

Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.

<p>Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.</p

Genetic risk score and the risk of TPOAb-positivity.

<p>GRS, genetic risk score (based on rs11675434, rs653178, rs10944479, rs1230666, rs2010099).</p>a<p>Adjusted for age and gender</p

Newly identified loci associated with TPOAb-positivity and/or serum TPOAb levels reaching genome wide significance.

<p>Chr., chromosome</p>a<p>Risk allele frequency: Weighted mean frequency of the risk allele across all included cohorts.</p>b<p>Adjusted for age and gender</p>c<p>Expressed in sd of natural logarithm transformed serum TPOAb level, adjusted for age and gender</p

Newly identified TPOAb associated loci and the risk of thyroid disease in stage 1 and 2 populations.

<p>All analyses adjusted for age and gender.</p><p><i>ATXN2</i>-rs653178 is in high LD with <i>SH2B3-</i> rs3184504</p><p><i>MAGI3-</i>rs1230666 is in high LD with <i>PTPN22-</i>rs2476601</p