Asymmetric Synthesis of Two Hydroxylated Pyrrolizidines From a C -Allyl Epoxypyrrolidine

International audienc

Enantioselective Stereodivergent Synthesis of Jaspine B and 4-epi-Jaspine B from Axially Chiral Allenols

International audienceA short enantioselective synthetic route to the cytotoxic marine natural jaspine B has been developed. A chiral non-racemic primary -allenol, obtained from pentadecanal, gave access to an enantioenriched 2-tetradecyl-2,5-dihydrofuran as key intermediate. A stereodivergent functionalization of this dihydrofuran allowed access in few steps to jaspine B and its 4-epimer

Synthesis of homo- and hetero-multivalent compounds against Gaucher disease.

International audienc

Transalpinecine and analogs: first total synthesis, stereochemical revision and biological evaluation

International audienc

Synthesis of homo- and hetero-multivalent compounds against Gaucher disease

International audienc

Transalpinecine and analogs: first total synthesis, stereochemical revision and biological evaluation

International audienc

Première synthèse totale et révision structurale de la Transalpinécine

International audienc

Asymmetric Synthesis of Two Hydroxylated Pyrrolizidines From a <i>C</i>-Allyl Epoxypyrrolidine

<div><p></p><p>The efficient two-step preparation of a new pivotal C-allyl epoxypyrrolidine intermediate from an enantio-enriched epoxyaldehyde precursor is described. The synthetic potential of this building block is demonstrated with the first enantioselective synthesis of two hydroxylated pyrrolizidine relying on a regio- and stereocontrolled epoxide opening reaction.</p></div

1-Ethyl-3-methylimidazolium tartrate chiral ionic liquids: preparation, characterization and opportunities thereof

International audienc