Metody leczenia pacjentów ze zmianami w naczyniach wieńcowych w przebiegu choroby Takayasu - opis przypadku i przegląd piśmiennictwa

Takayasu arteritis is type of vasculitis that usually affects the aorta and its major branches. While coronary involvement is seen infrequently, treatment strategy is less clear. Here, we report a case of a 45 year-old woman with Takayasu arteritis who underwent a Y-graft coronary bypass surgery four years previously. We present the long-term follow-up this patient, with a literature review. and we discuss treatment strategies. Kardiol Pol 2010; 68, 10: 1176-117

Left atrial thrombus following bilobectomy: a case report

<p>Abstract</p> <p>Introduction</p> <p>Left atrial free floating ball thrombus is a relatively rare event, especially without mitral valve disease.</p> <p>Case presentation</p> <p>A 61-year-old Turkish man was admitted to our hospital with a thrombus mass in his left atrium. Five months earlier, he had undergone right bilobectomy and superior bronchoplasty due to squamous cell carcinoma in the lung. The patient had no evidence of cardiac disease except atrial fibrillation and there were no defined embolizations. The thrombus mass was surgically removed. The patient was discharged from hospital on the sixth postoperative day.</p> <p>Conclusion</p> <p>Surgery with cardiopulmonary bypass is a safe method for treatment. The patient should be medicated with warfarin, especially in the presence of atrial fibrillation.</p

The role of perivascular adipose tissue on human saphenous vein vascular tone

Perivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein (SV). Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F-2 alpha (PGF(2 alpha)). However, potassium chloride (KCI)-induced concentration-response curve wasn't modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine (ACh) or endothelium-independent relaxation induced by sodium nitroprusside (SNP) were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists (KCI, PGF(2 alpha)) or relaxant agonists (SNP, ACh) were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF(2 alpha)-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factor(s)

The assessment of the relaxant effect of S-nitrosoglutathione on isolated human saphenous vein

S-nitrosothiols (RSNOs) are thought to represent the circulating reservoir of nitric oxide (NO). S-nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol which suggested to be a potent vasodilator with a prolonged relaxant effect compared to the current NO donors that clinically used. There are limited studies about its vascular effects on human vessels while no data is available on its mechanism of action. In this study, we aimed to investigate the acute effect of GSNO on human saphenous vein rings as well as the possible underlying mechanisms. Isolated human saphenous veins obtained from coronary artery bypass surgery, were mounted in an organ bath system, aerated with %5CO2 + %95o 2 at 37o C with a resting tension of 2g. The effect of GSNO (10-8 -10-4 M) were studied in a concentration-dependent manner on rings precontracted submaximally with phenylephrine (3x10-5 M). In order to analyse its mechanism of action, the effects of GSNO were studied in the absence and presence of NO synthase inhibitor, L-NAME (10-4 M, 30min), soluble guanylyl cyclase (sGC) inhibitor, ODQ (10-5 M, 30min) or a selective inhibitor of ATP-sensitive K+ channels (KATP), glibenclamide (10-5 M, 30min). GSNO produced concentration-dependent relaxant effects on precontracted human saphenous veins (Emax: 102,40±1,37%). The prominent relaxant influence of GSNO was not altered in the presence of the inhibitor of NO synthase or KATP channels. While, a significant decrease was observed with ODQ (ODQ-Emax: 43,73±8,61%; Control-Emax:108,4±4,76%, p&lt;0.001, n=5) Our results indicate that acute relaxant effects of GSNO in isolated human saphenous vein were neither mediated by KATP channel activation nor endogenous NO. Whereas, the activation of sGC pathway is likely be involved in this response. A better understanding of the mechanism regulating the vasorelaxant effect of GSNO and its possible role as a new antispasmodic agent for bypass graft spasms will provide us new therapeutic opportunities. Keywords: S-nitrosoglutathione, nitric oxide, coronary artery bypass graft, human saphenous vei

Caveolae depletion contributes to impaired relaxation induced by hydrogen sulfide in isolated human saphenous vein

3rd European Conference on the Biology of Hydrogen Sulfide (H2S) -- MAY 03-06, 2015 -- Athens, GREECEWOS: 00035331390005